Intrauterine exposure to 2,3′,4,4′,5-pentachlorobiphenyl alters spermatogenesis and testicular DNA methylation levels in F1 male mice

Tao, Yurong; Han, Xiaoying; Zhang, Lin; Jiang, Liyu; Ma, Ying; Meng, Lingjiao; He, Qi-Long; Liu, Shuzhen

doi:10.1016/j.ecoenv.2021.112652

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…The analyses on 7-week-old mice showed that the alterations of DNA methylation, which occurred during the embryonic stage, were also maintained after sexual maturity, highlighting the possibility of a lower reproductive capacity in adulthood. Indeed, this condition coexists with low sperm quality (in terms of sperm motility and deformation rate) and an increase in the diameter of the seminiferous tubules, underlining how prenatal exposure to PCB118 can lead to infertility through epigenetic modification [ 85 ].…”

Section: Link Between Toxicants Exposure Dna Methylation and Biologic...mentioning

confidence: 99%

Evolutionary Implications of Environmental Toxicant Exposure

et al. 2022

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Homo sapiens have been exposed to various toxins and harmful compounds that change according to various phases of human evolution. Population genetics studies showed that such exposures lead to adaptive genetic changes; while observing present exposures to different toxicants, the first molecular mechanism that confers plasticity is epigenetic remodeling and, in particular, DNA methylation variation, a molecular mechanism proposed for medium-term adaptation. A large amount of scientific literature from clinical and medical studies revealed the high impact of such exposure on human biology; thus, in this review, we examine and infer the impact that different environmental toxicants may have in shaping human evolution. We first describe how environmental toxicants shape natural human variation in terms of genetic and epigenetic diversity, and then we describe how DNA methylation may influence mutation rate and, thus, genetic variability. We describe the impact of these substances on biological fitness in terms of reproduction and survival, and in conclusion, we focus on their effect on brain evolution and physiology.

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Section: Link Between Toxicants Exposure Dna Methylation and Biologic...mentioning

confidence: 99%