Intrauterine fetal cystic hygromas: sonographic detection

Phillips, H. E.; McGahan, John P.

doi:10.2214/ajr.136.4.799

Cited by 45 publications

(26 citation statements)

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“…Studies comparing the expression of VEGFR-3 in lymphatic endothelium of lymphangiomas and healthy lymphatic vessels could show a higher expression of VEGFR-3 in lymphangiomas [26]. This result was confirmed by other study groups, which were able to detect an increased VEGFR-3 expression in lymphangioma [17,37,56].…”

Section: Molecular Characteristics Of Lymphatics and Lymphangiomassupporting

confidence: 62%

“…As a consequence of sequestered lymphatic tissue during the embryonic development in regions without regular connection to the normal lymphatic system [37], the missing communication to the lymphatic system could avoid the drainage of lymph fluid from the sequestered parts. Therefore, a lymphatic blockade may arise in a circumscribed area, possibly increasing in size as consequence of infections or traumata.…”

Section: Sequestration Of Lymph Tissuementioning

confidence: 99%

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Pathogenesis of lymphangiomas

et al. 2008

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Based on various hypotheses concerning lymphangiogenesis published in the literature, different putative mechanisms of lymphangioma development are discussed including failure of the lymphatic system to connect with or separate from the venous system, abnormal budding of the lymphatic system from the cardinal vein, or acquired processes such as traumata, infections, chronic inflammations, and obstructions. Increasingly, the possible influence of lymphangiogenic growth factors on the development of lymphangiomas is discussed. The proved expression of different growth factors in the endothelium of lymphangiomas leads to new hypotheses regarding the pathogenesis of lymphangiomas. Thus, further studies on the lymphangiogenesis and the development of lymphangiomas will have to clarify as to whether lymphangiomas are true malformations or neoplastic in nature.

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Section: Molecular Characteristics Of Lymphatics and Lymphangiomassupporting

confidence: 62%

Section: Sequestration Of Lymph Tissuementioning

confidence: 99%

Pathogenesis of lymphangiomas

et al. 2008

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“…Other sites reported for cystic hygroma are axilla (20%), mediastinum (5%), abdominal cavity, retroperitonuem, the scrotum and even the skeleton 6,7 . Jugular lymphatic obstruction sequence, abnormal embryonic sequestration of lymphatic tissue, or abnormal budding of the lymphatics results in cystic hygroma formation 6,8,9 . Vascular endothelial growth factor C (VEGF -C) is postulated to play role in lymphatic malformations 10 .…”

Section: Discussionmentioning

confidence: 99%

Cystic Hygroma of Wrist

Wani

Bhat

Amin

et al. 2012

J. Nepal Paedtr. Soc.

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Cystic hygroma is the rare congenital lesion. This is a cystic variety of lymphangioma. Cystic hygroma arising outside of the cervicofacial, thoracic, and abdominal areas are extremely rare. Wrist is a very rare site for occurrence of cystic hygroma. Presentation depends on site of location of cystic hygroma. A case of cystic hygroma of wrist in a child is reported. This child presented with painless swelling of left wrist. Excision of cyst was done. This is first case report of literature reporting occurrence of cystic hygroma on wrist.

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“…A cystic hygroma generally begins to develop between the 6th and 9th weeks of gestation due to failure of the jugular lymphatic sacs to drain into the internal jugular vein, which probably results in the dilatation of the lymphatic sacs into cystic spaces and may lead to the jugular lymphatic obstruction sequence and hydrops fetalis 1,2 . Prognosis of affected cases is poor.…”

Section: Letter To the Editor Prenatal Diagnosis Of A Huge Cystic Hygmentioning

confidence: 99%