Intrauterine fetal loss associated with candida glabrata chorioamnionitis: report of two cases

Özer, Erdener; Unlu, Mehtat Uz; Erşen, Ayça; Gülekli, Bülent

doi:10.5146/tjpath.2013.01154

Cited by 11 publications

(13 citation statements)

References 10 publications

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“…We identified 123 cases (102 singletons [ 4 , 8 – 76 ]/21 twins [ 49 , 62 , 69 , 77 – 90 ]) with Candida chorioamnionitis, including our nine cases for whom adequate maternal clinical data were available.…”

Section: Resultsmentioning

confidence: 99%

CandidaChorioamnionitis Leads to Preterm Birth and Adverse Fetal-Neonatal Outcome

Maki

Fujisaki

Sato

et al. 2017

Infectious Diseases in Obstetrics and Gynecology

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Candida chorioamnionitis is rare but can lead to neonatal infection, high mortality, and neurodevelopmental impairment. We aimed to investigate maternal clinical features and perinatal outcomes and discuss future management strategies. We reviewed the medical records of women with Candida chorioamnionitis at our hospital over a 10-year period (n = 9) and previous published case reports and case series. The most prevalent Candida species was C. albicans (71.3% of the all cases). The most prevalent predisposing condition was preterm premature rupture of membranes (31/123, 25.2%), followed by pregnancy with a retained intrauterine contraceptive device (26/123, 21.1%) and pregnancy after in vitro fertilization (25/123, 20.3%). Preterm labor was the most common symptom (52/123, 42.3%), and only 13% of cases involved fever. Of the infants, 27% of the singletons and 23.8% of the twins were born before 22 gestational weeks, while 60% of the singletons and 76.2% of the twins were born at 22–36 weeks. The median birth weight of the babies born after 22 weeks was 1230 g. The mortality rates of the singletons and twins born after 22 weeks of gestation in the year 2000 or later were 28.6% and 52.4%, respectively. Antenatal treatment for Candida chorioamnionitis has not been established.

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Section: Resultsmentioning

confidence: 99%

CandidaChorioamnionitis Leads to Preterm Birth and Adverse Fetal-Neonatal Outcome

Maki

Fujisaki

Sato

et al. 2017

Infectious Diseases in Obstetrics and Gynecology

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“…glabrata infection has also been reported as a cause of chorioamnionitis in healthy pregnant women [6][7][8]. The majority of cases appear to be reported in the IVF population and present at 15-24 weeks gestation.…”

Section: Discussionmentioning

confidence: 98%

“…The majority of cases appear to be reported in the IVF population and present at 15-24 weeks gestation. The authors propose that the possible source of infection is the lower genital tract, with introduction of organisms into the uterus at time of embryo transfer [6][7][8]. In the non-IVF population, C. glabrata chorioamnionitis has been associated with foreign bodies (cerclage and intrauterine devices) and immunosuppression (untreated gestational diabetes) [6].…”

Section: Discussionmentioning

confidence: 99%

Candida glabrata Sepsis in an Immunocompetent Individual: A Case Report

Tan¹,

Reddy²,

Gupta³

et al. 2017

Gynecol Obstet Case Rep

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Candidaemia accounts for a significant proportion of systemic fungal infections, with Candida glabrata (C. glabrata) becoming prominent in recent decades. We describe a unique case where postoperative urinary retention and C. glabrata UTI led to invasive fungaemia with bladder necrosis. A 37-year-old previously well nulliparous woman underwent an elective diagnostic laparoscopy, hysteroscopy dilation and curettage, and dye studies for investigation of infertility. She re-presented six days post procedure with C. glabrata urosepsis with a subsequent laparoscopy on day 16 revealing fungal plaques in the bladder, and a large necrotic defect in the bladder dome. The patient was managed with bilateral nephrostomies, a pelvic drain and antifungal therapy. Four weeks post-insertion of the nephrostomies, a cystogram revealed spontaneous closure of bladder defect. The nephrostomies were removed and antibiotics and antifungals continued for a month until negative urine cultures were attained. The patient was well four months after discharge with mild urinary symptoms. The literature has reported two cases of candida UTIs resulting in bezoars and bladder rupture, occurring only in immunocompromised patients. This case highlights the challenges of C. glabrata sepsis and its potential for severe morbidity in a non-immunocompromised patient, suggesting the need for guidelines in the early detection and treatment of C. glabrata sepsis.

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“…However, it actually has reduced virulence and migration ability across intact chorionic membranes as compared to Candida albicans . This may explain why the majority of the only 20 reported cases of C. glabrata chorioamnionitis in the literature [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19] involved some form of instrumentation and were associated with IVF [5,6,7,8,9,10,16,17,18,19] or presence of an intrauterine device [11,12,20,21]. …”

Section: Resultsmentioning

confidence: 99%

<b><i>Candida glabrata</i></b> Chorioamnionitis following in vitro Fertilization: Review of the Literature

Herman

Zussman

Haratz

et al. 2015

Gynecol Obstet Invest

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Aim: To review all past reports of Candida glabrata chorioamnionitis in the literature while noting their correlation with in vitro fertilization (IVF). Methods: We checked MEDLINE, PubMed and Google scholar (January 1970 to December 2014) for articles using the search terms ‘Candida', ‘Torulopsis', ‘glabrata', ‘chorioamnionitis', ‘congenital', ‘perinatal' and ‘infection'. Case reports were included if they described a verified intrauterine infection with C. glabrata. The authors reviewed the articles and abstracted the data. 20 cases were compared, including a case reported from our institution shortly described in this article. Results: 13 of 20 cases (65%) involved pregnancies achieved by IVF; 3 patients underwent amniocentesis during their pregnancy. Of the 7 cases with no history of IVF, 2 involved a history of cerclage and 2 a history of intrauterine device use. Only 6 infants survived, delivered prematurely by cesarean section. Conclusions: Review of literature demonstrated a high prevalence of IVF-assisted pregnancies among the few C. glabrata chorioamnionitis cases previously described, typically occurring during the second trimester. Additional cases were notable for additional instrumentation/invasive procedure. The prognosis was mostly grim, entailing a high incidence of stillbirth or rapid neonatal death.

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Intrauterine fetal loss associated with candida glabrata chorioamnionitis: report of two cases

Cited by 11 publications

References 10 publications

CandidaChorioamnionitis Leads to Preterm Birth and Adverse Fetal-Neonatal Outcome

CandidaChorioamnionitis Leads to Preterm Birth and Adverse Fetal-Neonatal Outcome

Candida glabrata Sepsis in an Immunocompetent Individual: A Case Report

<b><i>Candida glabrata</i></b> Chorioamnionitis following in vitro Fertilization: Review of the Literature

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