Intrauterine food restriction alters the expression of uncoupling proteins in brown adipose tissue of rat newborns

Souza, Thais L.V.; Coelho, Carolina Tesone; Guimarães, Paola Bianchi; Goto, Eduardo M.; Silva, Sylvia Maria A.; Silva, José António; Nunes, Maria Tereza; Ihara, Sílvia Saiuli Miki; Luz, Jacqueline

doi:10.1016/j.jtherbio.2011.12.002

Cited by 2 publications

(2 citation statements)

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“…In sheep, maternal nutrient restriction in late gestation results in a 2.5-fold decrease in the abundance of UCP1 mRNA in near-term fetal adipose tissue, but there is no effect on protein abundance at this stage (6). On the other hand, longer periods of nutrient restriction, extending throughout pregnancy, increase UCP1 expression in both sheep (6) and rats (25). Reduction in UCP1 when nutrition is restricted only in the late gestation may be an adaptation to conserve energy for the growth of other vital organs (6).…”

Section: Discussionmentioning

confidence: 97%

Brown adipose tissue genes in pericardial adipose tissue of newborn sheep are downregulated by maternal nutrient restriction in late gestation

et al. 2013

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Background: Brown adipose tissue (BAT) thermogenesis is essential for newborn survival. Pericardial adipose tissue is a visceral depot that promotes metabolic and cardiovascular adaptations. We determined whether BAT is present in pericardial adipose tissue in newborns and whether maternal nutrition during late gestation compromises BAT in the postnatal period. Methods: We measured uncoupling protein 1 (UCP1) and other BAT-specific genes (e.g., β3-adrenergic receptor (β3ADR) and deiodinase type 2 (DIO2)), together with markers of white adipose tissue (WAT) in sheep on either the first or 30th day after birth. These were twin offspring born to mothers fed with either 100% or nutrient restricted (NR) to 60% of their total metabolizable requirements from 110 d gestation to term. results: Gene expression of UCP1 and other BAT-related genes decreased significantly with age. In newborns, maternal nutrient restriction downregulated gene expression of DIO2 and the β3-adrenergic receptor with reduced UCP1 but had no effect on genes predominantly expressed in WAT. conclusion: BAT is present around the heart in newborns. Exposure to a suboptimal maternal diet in late gestation specifically compromises BAT development and has the potential to place these offspring at increased risk of hypothermia after birth without effects on the subsequent appearance of WAT.

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Section: Discussionmentioning

confidence: 97%

Brown adipose tissue genes in pericardial adipose tissue of newborn sheep are downregulated by maternal nutrient restriction in late gestation

et al. 2013

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“…The results showed an increase in UPC 1 and UCP 2 production in response to the decrease in the amount of body mass and fat content of the pups, causing excessive heat loss as well as the inability to thermoregulate. However, there were no significant changes in the expression of UCP 3 and SERCA 1 [ 183 ].…”

Section: Extrinsic Factors Involvedmentioning

confidence: 99%

The Role of Brown Adipose Tissue and Energy Metabolism in Mammalian Thermoregulation during the Perinatal Period

Bienboire-Frosini

Wang

Marcet-Rius

et al. 2023

Animals

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Hypothermia is one of the most common causes of mortality in neonates, and it could be developed after birth because the uterus temperature is more elevated than the extrauterine temperature. Neonates use diverse mechanisms to thermoregulate, such as shivering and non-shivering thermogenesis. These strategies can be more efficient in some species, but not in others, i.e., altricials, which have the greatest difficulty with achieving thermoneutrality. In addition, there are anatomical and neurological differences in mammals, which may present different distributions and amounts of brown fat. This article aims to discuss the neuromodulation mechanisms of thermoregulation and the importance of brown fat in the thermogenesis of newborn mammals, emphasizing the analysis of the biochemical, physiological, and genetic factors that determine the distribution, amount, and efficiency of this energy resource in newborns of different species. It has been concluded that is vital to understand and minimize hypothermia causes in newborns, which is one of the main causes of mortality in neonates. This would be beneficial for both animals and producers.

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Intrauterine food restriction alters the expression of uncoupling proteins in brown adipose tissue of rat newborns

Cited by 2 publications

References 45 publications

Brown adipose tissue genes in pericardial adipose tissue of newborn sheep are downregulated by maternal nutrient restriction in late gestation

Brown adipose tissue genes in pericardial adipose tissue of newborn sheep are downregulated by maternal nutrient restriction in late gestation

The Role of Brown Adipose Tissue and Energy Metabolism in Mammalian Thermoregulation during the Perinatal Period

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