Intrauterine Growth Restriction Associated with Hematologic Abnormalities: Probable Manifestations of Placental Mesenchymal Dysplasia

Martínez‐Payo, C.; Bernabéu, R. Alvarez; Villar, Isabel; Goy, Enrique Iglesias

doi:10.1055/s-0034-1394152

Cited by 3 publications

(1 citation statement)

References 11 publications

(18 reference statements)

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“…Of course, other pathologies are able to cause "non-traumatic" fat embolism (NTFE), such as sickle cell crisis, fatty liver disease, total parenteral nutrition, prolonged steroid use and non-traumatic joint arthroplasty [46,47]. FE has been reported in the perinatal period around childbirth, although extremely rare [48].…”

Section: Discussionmentioning

confidence: 99%

Cerebral fat embolism after traumatic bone fractures: a structured literature review and analysis of published case reports

Vetrugno

Bignami

Deana

et al. 2021

Scand J Trauma Resusc Emerg Med

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Background The incidence of cerebral fat embolism (CFE) ranges from 0.9–11%, with a mean mortality rate of around 10%. Although no univocal explanation has been identified for the resulting fat embolism syndrome (FES), two hypotheses are widely thought: the ‘mechanical theory’, and the ‘chemical theory’. The present article provides a systematic review of published case reports of FES following a bone fracture. Methods We searched MEDLINE, Web of Science and Scopus to find any article related to FES. Inclusion criteria were: trauma patients; age ≥ 18 years; and the clinical diagnosis of CFE or FES. Studies were excluded if the bone fracture site was not specified. Results One hundred and seventy studies were included (268 cases). The male gender was most prominent (81.6% vs. 18.4%). The average age was 33 years (±18). The mean age for males (29 ± 14) was significantly lower than for females (51 ± 26) (p < 0.001). The femur was the most common fracture site (71% of cases). PFO was found in 12% of all cases. Univariate and multivariate regression analyses showed the male gender to be a risk factor for FES: RR 1.87 and 1.41, respectively (95%CI 1.27–2.48, p < 0.001; 95%CI 0.48–2.34, p < 0.001). Conclusions FES is most frequent in young men in the third decades of life following multiple leg fractures. FES may be more frequent after a burst fracture. The presence of PFO may be responsible for the acute presentation of cerebral embolisms, whereas FES is mostly delayed by 48–72 h.

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Section: Discussionmentioning

confidence: 99%

Cerebral fat embolism after traumatic bone fractures: a structured literature review and analysis of published case reports

Vetrugno

Bignami

Deana

et al. 2021

Scand J Trauma Resusc Emerg Med

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Diagnostic value of alpha-fetoprotein in the implementation of non-immune fetal hydrops due to parvovirus b19 infection during pregnancy

Ventskivska

Bondarenko

Vitovskyi

et al. 2022

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Background. Intrauterine infection remains the main problem of perinatology. Early diagnosis of such infection causes enough difficulties and requires improvement. This study is devoted to the problem of predicting non-immune fetal hydrops if a woman is infected with parvovirus B19 in the II trimester of pregnancy.Objectives: to improve the diagnosis of non-immune fetal hydrops on the basis of changes in the α-fetoprotein (AFP) value in maternal blood during parvovirus B19 infection .Materials and methods. Serial AFP determination in blood serum of pregnant women infected with parvovirus B19 (n = 16) at 18–20–22 weeks of pregnancy was carried out. Biochemical analysis of AFP in amniotic fluid was performed after prenatal invasive examination in fetuses with non-immune hydrops. The obtained data were compared with similar indicators of pregnant women from the control group (n = 16) with a normal course of pregnancy in the II trimester. Transabdominal amniocentesis was performed under ultrasound control at 16–20 weeks of gestation for fetuses with non-immune hydrops. Determination of the AFP value in the blood serum of pregnant women in the II trimester was performed with a chemiluminescence immunoassay analyzer.Results. It was established that the AFP level in maternal blood reaches and exceeds threshold values (2.6 ± 0.05 MoM) on average 2.5 ± 0.5 weeks before the manifestation of severe fetal anemia in infected fetus with non-immune hydrops (r = 0.768, p < 0.001). That is, a sharp AFP increase in the blood of a pregnant woman infected with parvovirus B19 is a predictor of the development of non-immune fetal hydrops due to parvovirus B19 infection.Conclusions. The described method has proven to be highly effective, it is allows reducing the frequency of ultrasound examinations for infected women, because the fetus is not always infected from an infected mother. This technique can be used as a predictor of intrauterine parvovirus B19 infection in the II trimester, which will allow the development of new approaches to the early diagnosis of non-immune fetal hydrops, as well as contribute to timely intrauterine hemotransfusion.

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A rare case of placental mesenchymal dysplasia – case report and literature review

Dumitru

Vasilescu²,

Meca³

et al. 2021

Rom J Morphol Embryol

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Described as a rare anomaly of the placenta, with a reported incidence of 0.02%, mesenchymal dysplasia is a benign condition characterized by placentomegaly, grape-like vesicles and by microscopic features resembling those of a molar pregnancy, such as hydropic villi, cistern formation and dysplastic blood vessels. We report a rare case of placental mesenchymal dysplasia diagnosed in a pregnancy with early symmetric fetal intrauterine growth restriction and a normal karyotype. Based on this case report, we discuss the particularities of this condition, emphasizing the ultrasonography and histopathological findings.

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Intrauterine Growth Restriction Associated with Hematologic Abnormalities: Probable Manifestations of Placental Mesenchymal Dysplasia

Cited by 3 publications

References 11 publications

Cerebral fat embolism after traumatic bone fractures: a structured literature review and analysis of published case reports

Cerebral fat embolism after traumatic bone fractures: a structured literature review and analysis of published case reports

Diagnostic value of alpha-fetoprotein in the implementation of non-immune fetal hydrops due to parvovirus b19 infection during pregnancy

A rare case of placental mesenchymal dysplasia – case report and literature review

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