Intrauterine growth restriction: impact on cardiovascular development and function throughout infancy

Cohen, Emily; Wong, Flora Y.; Horne, Rosemary Sylvia Claire; Yiallourou, Stephanie

doi:10.1038/pr.2016.24

Cited by 105 publications

(83 citation statements)

References 86 publications

(172 reference statements)

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“…In addition, intrauterine growth restriction, observed in the PE model, might also have a direct effect on organ development, such as the kidney and the heart, contributing to the increased cardiovascular risk observed in the offspring exposed to PE (36).…”

Section: Discussionmentioning

confidence: 99%

Pravastatin therapy during preeclampsia prevents long-term adverse health effects in mice

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Pravastatin therapy during preeclampsia prevents long-term adverse health effects in mice

et al. 2018

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“…Uteroplacental vascular insufficiency, the main cause of IUGR, results in chronic oxygen and nutrient deprivation. Fetal circulatory adaptations compensate for growth restriction, but also program the fetus for increased risk of hypertension, cardiovascular disease and type 2 diabetes later in life (Osmond and Barker, 2000;Cohen et al, 2016). It would be of interest to determine whether the IUGR observed in Egfl7 −/− embryos is linked to morbidities in the adult.…”

Section: Discussionmentioning

confidence: 99%

Altered feto-placental vascularization, feto-placental malperfusion, and fetal growth restriction in mice with Egfl7 loss-of-function

et al. 2017

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EGFL7 is a secreted angiogenic factor produced by embryonic endothelial cells. To understand its role in placental development, we established a novel Egfl7 knockout mouse. The mutant mice have gross defects in chorioallantoic branching morphogenesis and placental vascular patterning. Microangiography and 3D imaging revealed patchy perfusion of Egfl7 −/− placentas marked by impeded blood conductance through sites of narrowed vessels. Consistent with poor feto-placental perfusion, Egfl7 knockout resulted in reduced placental weight and fetal growth restriction. The placentas also showed abnormal fetal vessel patterning and over 50% reduction in fetal blood space. In vitro, placental endothelial cells were deficient in migration, cord formation and sprouting. Expression of genes involved in branching morphogenesis, Gcm1, Syna and Synb, and in patterning of the extracellular matrix, Mmrn1, were temporally dysregulated in the placentas. Egfl7 knockout did not affect expression of the microRNA embedded within intron 7. Collectively, these data reveal that Egfl7 is crucial for placental vascularization and embryonic growth, and may provide insight into etiological factors underlying placental pathologies associated with intrauterine growth restriction, which is a significant cause of infant morbidity and mortality.

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“…IUGR is associated with systemic vascular remodelling [18]. Histological changes of the ductus arteriosus have also been reported [19].…”

Section: Discussionmentioning

confidence: 99%

Reduction in Cerebral Oxygenation due to Patent Ductus Arteriosus Is Pronounced in Small-for-Gestational-Age Neonates

Cohen

Dix²,

Baerts³

et al. 2016

Neonatology

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Background: A haemodynamically significant patent ductus arteriosus (hsPDA) reduces cerebral oxygenation in appropriate-for-gestational-age (AGA) preterm neonates. Reduced cerebral oxygenation has been associated with brain injury. Preterm small-for-gestational-age (SGA) neonates show higher cerebral oxygenation than AGA peers throughout the first postnatal days. To date, no studies have investigated the effect of hsPDA on cerebral oxygenation in preterm SGA neonates. Objective: We aimed to assess the effect of hsPDA on cerebral oxygenation in preterm SGA neonates compared to AGA peers. We hypothesised that higher baseline cerebral oxygenation would reduce the impact of hsPDA on cerebral oxygenation in preterm SGA neonates. Methods: We monitored regional cerebral oxygen saturation (rScO₂) with near-infrared spectroscopy and calculated the cerebral fractional tissue oxygen extraction (cFTOE) for 72 h after birth. Retrospective analysis compared 36 preterm SGA neonates (birth weight <10th percentile, 18 with hsPDA) to 36 preterm AGA neonates (birth weight 20th to 80th percentile, 18 with hsPDA). Results: In contrast to the other groups, SGA-hsPDA neonates demonstrated a significant fall in rScO₂ [69% (SEM 2.5) at 4-8 h to 61% (2.7) at 68-72 h, p < 0.001] with a concurrent rise in cFTOE [0.26 (0.026) at 4-8 h to 0.34 (0.030) at 68-72 h, p < 0.001]. Conclusions: Contrary to our hypothesis, hsPDA had a significant negative effect on cerebral oxygenation in preterm SGA neonates. Future studies should explore the potential benefits of early screening and treatment for hsPDA on long-term neurodevelopmental outcome in preterm SGA neonates.

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Intrauterine growth restriction: impact on cardiovascular development and function throughout infancy

Cited by 105 publications

References 86 publications

Pravastatin therapy during preeclampsia prevents long-term adverse health effects in mice

Pravastatin therapy during preeclampsia prevents long-term adverse health effects in mice

Altered feto-placental vascularization, feto-placental malperfusion, and fetal growth restriction in mice with Egfl7 loss-of-function

Reduction in Cerebral Oxygenation due to Patent Ductus Arteriosus Is Pronounced in Small-for-Gestational-Age Neonates

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