Intrauterine growth restriction is associated with structural alterations in human umbilical cord and decreased nitric oxide-induced relaxation of umbilical vein

Peyter, Anne‐Christine; Delhaes, Flavien; Baud, David; Vial, Yvan; Diaceri, Giacomo; Ménetrey, Steeve; Hohlfeld, P.; Tolsa, Jean-François

doi:10.1016/j.placenta.2014.08.090

Cited by 29 publications

(13 citation statements)

References 43 publications

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“…6), we cannot specify at which exact diameters this occurs. Previous studies examining human fetal placental venous structure are sparse, though some reports have linked alterations in umbilical vein structure to FGR 32, 33 . The consequences of these previously unreported altered vessel path lengths on blood flow to the fetus are unknown.…”

Section: Discussionmentioning

confidence: 99%

Whole organ vascular casting and microCT examination of the human placental vascular tree reveals novel alterations associated with pregnancy disease

Junaid

Bradley

Lewis

et al. 2017

Sci Rep

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Experimental methods that allow examination of the intact vascular network of large organs, such as the human placenta are limited, preventing adequate comparison of normal and abnormal vascular development in pregnancy disease. Our aims were (i) to devise an effective technique for three-dimensional analyses of human placental vessels; (ii) demonstrate the utility of the technique in the comparison of placental vessel networks in normal and fetal growth restriction (FGR) complicated pregnancies. Radiopaque plastic vessel networks of normal and FGR placentas (n = 12/group) were created by filling the vessels with resin and corroding the surrounding tissues. Subsequently, each model was scanned in a microCT scanner, reconstructed into three-dimensional virtual objects and analysed in visualisation programmes. MicroCT imaging of the models defined vessel anatomy to our analyses threshold of 100 µm diameter. Median vessel length density was significantly shorter in arterial but longer in venous FGR networks compared to normals. No significant differences were demonstrable in arterial or venous tortuosity, diameter or branch density. This study demonstrates the potential effectiveness of microCT for ex-vivo examination of human placental vessel morphology. Our findings show significant discrepancies in vessel length density in FGR placentas. The effects on fetoplacental blood flow, and hence nutrient transfer to the fetus, are unknown.

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Section: Discussionmentioning

confidence: 99%

Whole organ vascular casting and microCT examination of the human placental vascular tree reveals novel alterations associated with pregnancy disease

Junaid

Bradley

Lewis

et al. 2017

Sci Rep

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“…37,38 In this cohort, 24% of the preterm were affected by PE, which has previously been shown to adversely affect umbilical cord vessel development. [43][44][45] We found that there was a trend towards increased %collagen deposition in the umbilical arteries of preterm infants exposed to maternal PE compared with GAmatched controls. Although functional measures of compliance were not performed, this study corroborates previous findings of increased collagen content in the umbilical arteries associated with PE.…”

Section: Discussionmentioning

confidence: 70%

“…Although functional measures of compliance were not performed, this study corroborates previous findings of increased collagen content in the umbilical arteries associated with PE. [43][44][45] Others have associated this increased collagen with decreased compliance by functional measures which may account for the hypertension and stroke that is observed in these individuals in later life. 46,47 Abnormal placental function with maternal PE has been associated with impaired nephrogenesis independent of overt fetal growth restriction.…”

Section: Discussionmentioning

confidence: 99%

Umbilical artery histomorphometry: a link between the intrauterine environment and kidney development

DeFreitas

Mathur

Seeherunvong

et al. 2017

J Dev Orig Health Dis

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Prematurity is a risk factor for hypertension, vascular stiffness, nephron deficit and adult onset cardiorenal disease. The vascular tree and kidneys share morphogenic drivers that promote maturation in utero before 36 weeks of gestation. Vascular elastin accrual terminates after birth leaving collagen to promote vascular stiffness. Our objective was to determine if the histomorphometry of the umbilical artery, an extension of the aorta, parallels nephron mass across gestational age groups. From a cohort of 54 newborns, 32 umbilical cord specimens were adequate for evaluation. The umbilical cord was sectioned, stained with trichrome, and digitalized. Muscular and collagenous areas of the umbilical artery were measured in pixels using the Image J 1.48q software. Total kidney volume was measured by ultrasound and factored by body surface area (TKV/BSA). The umbilical artery total area was significantly greater in term v. preterm infants (9.3±1.3 v. 7.0±2.0 mm2; P<0.05) and increased with gestational age; while the percent muscular and collagen areas were independent of gestational age (R 2=0.04; P=ns). Percent muscular area correlated positively with TKV/BSA (r=0.53; P=0.002); while an increase in collagen correlated inversely with kidney mass (r=-0.53; P=0.002). In conclusion, an enhanced % muscular area and presumed vascular elasticity was associated with increased renal mass in all infants. Umbilical artery histomorphometry provides a link between the intrauterine environment, vascular and kidney development.

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“…This explains poor angiogenisis in umbilical vessel of IUGR. 17,18 Hemodynamic factors also play a role in structural remodeling of vessels. Continuous blood flow through the vessels regulates the vascular transwall pressure and maintains structural integrity of umbilical vessels.…”

Section: Discussionmentioning

confidence: 99%

Histomorphometry of umbilical vessels of intrauterine growth restricted neonates

Kotrannavar

Shirol

Dhumale

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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Intrauterine growth restriction is associated with structural alterations in human umbilical cord and decreased nitric oxide-induced relaxation of umbilical vein

Cited by 29 publications

References 43 publications

Whole organ vascular casting and microCT examination of the human placental vascular tree reveals novel alterations associated with pregnancy disease

Whole organ vascular casting and microCT examination of the human placental vascular tree reveals novel alterations associated with pregnancy disease

Umbilical artery histomorphometry: a link between the intrauterine environment and kidney development

Histomorphometry of umbilical vessels of intrauterine growth restricted neonates

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