Intrauterine growth restriction leads to a high-corticosterone producing offspring: An implication for pulmonary infection susceptibility

Gil, Noemi Lourenço; Azevedo, Gabriela A.; Balbino, Aleksandro Martins; Silva, Marina M.; Carvalho, Maria Helena Catelli de; Akamine, Eliana Hiromi; Keller, Alexandre C.; Landgraf, Richardt Gama; Landgraf, Maristella de Almeida

doi:10.1016/j.lfs.2021.119764

Cited by 4 publications

(3 citation statements)

References 49 publications

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“…We showed that the risk of pulmonary infections was higher in ICU patients after the invasive surgery. This is similar to the study by Gil et al 20 We may speculate that postoperative ICU patients often need to undergo invasive procedures such as tracheal intubation and deep vein intubation, which can reduce the body’s defense function and increase the risk of pulmonary infection.…”

Section: Discussionsupporting

confidence: 88%

Construction of a prediction model for pulmonary infection and its risk factors in Intensive Care Unit patients

Dai,

Zhong,

Chen

et al. 2024

Pak J Med Sci

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Objective: To identify independent risk factors of pulmonary infection in intensive care unit (ICU) patients, and to construct a prediction model. Methods: Medical data of 398 patients treated in the ICU of Jiaxing Hospital of Traditional Chinese Medicine from January 2019 to January 2023 were analyzed. Univariate and multivariate logistic regression analyses were used to identify independent risk factors for pulmonary infection in ICU patients. R software was used to construct a nomogram prediction model, and the prediction model was internally validated using computer simulation bootstrap method. Predictive value of the model was analyzed using the receiver operating characteristic (ROC) curve. Results: A total of 97 ICU patients (24.37%) developed pulmonary infection. Age, ICU stay time, invasive operation, diabetes, duration of mechanical ventilation, and state of consciousness were all identified as risk factors for pulmonary infection. The calibration curve of the constructed nomogram prediction model showed a good consistency between the predicted value of the model and the actual observed value. ROC curve analysis showed that the area under the curve (AUC) of the model was 0.784 (95% CI: 0.731-0.837), indicating a certain predictive value. Conclusions: Age, length of stay in ICU, invasive operation, diabetes, duration of mechanical ventilation, and state of consciousness are risk factors for pulmonary infection in ICU patients. The nomogram prediction model constructed based on the above risk factors has shown a good predictive value. doi: https://doi.org/10.12669/pjms.40.6.9307 How to cite this: Dai W, Zhong T, Chen F, Shen M, Zhu L. Construction of a prediction model for pulmonary infection and its risk factors in Intensive Care Unit patients. Pak J Med Sci. 2024;40(6):1129-1134. doi: https://doi.org/10.12669/pjms.40.6.9307 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 88%

Construction of a prediction model for pulmonary infection and its risk factors in Intensive Care Unit patients

Dai,

Zhong,

Chen

et al. 2024

Pak J Med Sci

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“…Low birth weight is thought to impair immune system development and is reported as a risk factor for lower respiratory infection ( 33 , 34 ), tuberculosis ( 35 ), and severe sepsis caused by respiratory infection or primary bacteremia ( 36 ). In fact, a recent study reported that low-birth-weight rats exhibited a lower inflammatory response to lipopolysaccharide instillation than normal-birth-weight rats ( 37 ). Although the influence of low weight on the oral mucosal immune system is unclear, this acquisition of maternal oral bacteria might be caused by dysregulated colonization due to prolonged immature immunity, rather than the construction of a normal microbial community.…”

Section: Discussionmentioning

confidence: 99%

High-Level Acquisition of Maternal Oral Bacteria in Formula-Fed Infant Oral Microbiota

Kageyama

Furuta

Takeshita

et al. 2022

mBio

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“…Thereby, we could exclude a confounding influence of these factors to the findings related to SGA. Intrauterine growth restriction and SGA have been liked with several congenital anomalies, increased morbidity in the neonatal period, neurodevelopmental issues and a higher risk of metabolic syndrome and obesity as well as a higher risk of infections [27,10,11]. This theory, similar to the thrifty gene hypothesis, may underline the observed postnatal effects, potentially also influencing surgical complication rates [12].…”

Section: + Modelmentioning

confidence: 99%

Being born small for gestational age (SGA) might be associated with a higher reoperation rate in proximal hypospadias

Haid¹,

Tack

Spinoit

et al. 2022

Journal of Pediatric Urology

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Intrauterine growth restriction leads to a high-corticosterone producing offspring: An implication for pulmonary infection susceptibility

Cited by 4 publications

References 49 publications

Construction of a prediction model for pulmonary infection and its risk factors in Intensive Care Unit patients

Construction of a prediction model for pulmonary infection and its risk factors in Intensive Care Unit patients

High-Level Acquisition of Maternal Oral Bacteria in Formula-Fed Infant Oral Microbiota

Being born small for gestational age (SGA) might be associated with a higher reoperation rate in proximal hypospadias

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