Intrauterine infusion of platelet‐rich plasma is a treatment method for patients with intrauterine adhesions after hysteroscopy

Peng, Jintao; Li, Manchao; Zeng, Haitao; Zeng, Zhi; Huang, Jiana; Liang, Xiaoyan

doi:10.1002/ijgo.13353

Cited by 16 publications

(5 citation statements)

References 23 publications

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“…Administration of PRP has achieved encouraging results in the treatment of thin endometrium, intrauterine adhesions, endometrium-associated infertility, and recurrent implantation failure (RIF). [33][34][35][36] Our previous research found that PRP possessed antiinflammatory effects on LPS-induced endometritis in mice. 19 Whereas, the repair mechanisms in endometrial tissues remains largely unexplored.…”

Section: Discussionmentioning

confidence: 97%

“…In recent years, biotherapy has been gaining popular attention and scientific endorsement for the treatment of endometritis. Administration of PRP has achieved encouraging results in the treatment of thin endometrium, intrauterine adhesions, endometrium‐associated infertility, and recurrent implantation failure (RIF) 33–36 . Our previous research found that PRP possessed anti‐inflammatory effects on LPS‐induced endometritis in mice 19 .…”

Section: Discussionmentioning

confidence: 99%

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Platelet rich plasma alleviates endometritis induced by lipopolysaccharide in mice via inhibiting TLR4/NF‐κB signaling pathway

Liu,

Wang,

Wen

et al. 2024

American J Rep Immunol

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BackgroundEndometritis is an inflammatory reaction of the lining of uterus, leading to the occurrence of infertility. Platelet rich plasma (PRP) has been proven to exhibit extremely effective for the treatment of endometrium‐associated infertility, but the mechanism of its prevention for endometritis remains unclear.ObjectiveThe present study aimed to investigate the protective effect of PRP against endometritis induced by lipopolysaccharide (LPS) and elucidate the mechanism underlying these effects.MethodsMouse model of endometritis was established by intrauterine perfusion of LPS. PRP intrauterine infusion was administered at 24 h after LPS induction. After another 24 h, the uterine tissues were harvested to observe histopathological changes, production of proinflammatory cytokines, variation of the Toll‐like receptor 4/nuclear factor κB (TLR4/NF‐κB) signaling pathways, and validated the anti‐inflammatory effect of PRP. The myeloperoxidase (MPO) activity and concentration of nitric oxide (NO) were determined using assay kit. Proinflammatory chemokines (tumor necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β), and interleukin‐6 (IL‐6)) were measured by ELISA and Real‐Time PCR. The activity of TLR4/NF‐κB pathway in uterine tissues was measured by Western blotting.ResultsHematoxylin‐eosin staining (H&E) appeared that PRP remarkably relieved the impairment of uterine tissues. Detection of MPO activity and concentration of NO revealed that PRP treatment distinctly mitigated infiltration of inflammatory cells in mice with endometritis induced by LPS. PRP treatment significantly affected the expression of TNF‐α, IL‐1β, and IL‐6. PRP was also found to suppress LPS‐induced activation of TLR4/NF‐κB pathway.ConclusionPRP effectively alleviates LPS‐induced endometritis via restraining the signal pathway of TLR4/NF‐κB. These findings provide a solid foundation for PRP as a potential therapeutic agent for endometritis.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Platelet rich plasma alleviates endometritis induced by lipopolysaccharide in mice via inhibiting TLR4/NF‐κB signaling pathway

Liu,

Wang,

Wen

et al. 2024

American J Rep Immunol

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“…Peng et al [ 27 ]. conducted a retrospective cohort study to explore the effectiveness of PRP by comparing the IUA scores and postoperative chemical pregnancy rates of the PRP and balloon groups after surgery.…”

Section: Discussionmentioning

confidence: 99%

Platelet-Rich Plasma Improves Pregnancy Outcomes in Moderate to Severe Intrauterine Adhesion: A Retrospective Cohort Study

Qiu

Xiao

Wang

et al. 2023

JCM

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The purpose of the present study was to investigate the therapeutic effects of platelet-rich plasma (PRP) in women with moderate to severe intrauterine adhesion (IUA). A retrospective cohort study was conducted at a reproductive medical center between July 2020 and June 2021 to compare the clinical pregnancy rate of two groups (PRP and non-PRP groups) after hysteroscopic adhesiolysis. A multivariate logistic regression analysis and propensity score matching (PSM) were performed to minimize potential bias. According to our inclusion and exclusion criteria, 133 patients were finally enrolled and divided into the PRP group (n = 48) and non-PRP group (n = 85). In the primary comparison, the clinical pregnancy rate in the PRP group was higher than that in the non-PRP group (41.7% vs. 28.2%, p = 0.114), albeit without statistical significance. Multivariate logistic regression analysis was performed, and the results of the adjusted model showed that PRP treatment significantly improved the clinical pregnancy rate (adjusted OR = 3.00, 95% CI = 1.22–7.38, p = 0.017). After PSM, the clinical pregnancy rate was higher in the PRP group than that in the non-PRP group (46.2% vs. 20.5%, p = 0.031). Based on the present study, we concluded that intrauterine perfusion of PRP had great potential in improving the clinical pregnancy rate in patients with moderate to severe IUA. Therefore, we recommend the application of PRP in the treatment of IUA.

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“…In order to reduce the recurrence rate of IUA and improve reproductive prognosis, it is often recommended to assist other prevention and treatment measures for comprehensive management of adhesions after the surgery (16-18). These measures mainly include devices to keep opposing endometrial surfaces separated, such as intrauterine device (IUD) (19), Foley catheter balloon (20), auto-crosslinked hyaluronic acid (ACP) gel (21)(22)(23)(24), and interventions to promote endometrial regeneration, such as estrogen (25,26), stem cell (27)(28)(29), stem cell exosome (30), amniotic epithelial cells (31), granulocyte colony stimulating factor (32), platelet rich plasma (33), aspirin (34), etc. However, current effectiveness is still not ideally.…”

Section: Introductionmentioning

confidence: 99%

The Top 100 Most Cited Articles on Intrauterine Adhesion: A Bibliometric Analysis

2021

Preprint

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Background: Bibliometric analysis is a statistical method which attempts to assess articles by their citations, analyzing their frequency and pattern of citing phenomenon. Through the analysis, some guidance can be extracted for future research directions. Over the past few years, there have been articles published in mounting numbers focused on intrauterine adhesions. Nevertheless, little is known about the properties and qualities of these researches. No existed analysis commits to reflecting the progress of researches in intrauterine adhesion.Methods: Web of Science Core Collection, BIOSIS Citation Index and MEDLINE were searched for the identifying articles released from 1950 to October 2020. Articles concerning about Intrauterine adhesion were determined. Subsequently, the 100 most cited articles were chosen for analysis of citation count, citation density (citations/article age), authorship, theme, geographic distribution, time-related flux, level of evidence, and network analysis.Results: An overwhelming majority of the certain 100 articles were put out in the 2010s (35%). Citations per article ranged from 30 to 253. China possesses the most papers among the top 100 papers, followed by the USA, France, Israel and Italy. The study theme that most highlighted were operative hysteroscopy and adjunctive treatments for improving reproductive outcome. Level II is the most common level of evidence, and there is no statistical difference in the number of citations between the levels. The network analysis connoted that hysteroscopy, hysteroscopic adhesiolysis, infertility, and reproductive outcome had a great degree of centrality in the 2000s and 2010s, while placental implantation had a great degree of centrality in the 2000s and stem cell and fibrosis had a great degree of centrality in the 2010s. Conclusions: We conducted a bibliometric analysis of the top 100 most cited articles in the literature on intrauterine adhesions. It is worth noting that hysteroscopy and hysteroscopic adhesiolysis were long-term concern in the field of intrauterine adhesion researches. As the elapse of time, postoperative adjuvant treatment has gradually become the hot spot of researches. However, there are only 9 experimental articles among these 100 articles, showing the lack of breakthrough progress in the field of intrauterine adhesions at the mechanism level.

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Intrauterine infusion of platelet‐rich plasma is a treatment method for patients with intrauterine adhesions after hysteroscopy

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 16 publications

References 23 publications

Platelet rich plasma alleviates endometritis induced by lipopolysaccharide in mice via inhibiting TLR4/NF‐κB signaling pathway

Platelet rich plasma alleviates endometritis induced by lipopolysaccharide in mice via inhibiting TLR4/NF‐κB signaling pathway

Platelet-Rich Plasma Improves Pregnancy Outcomes in Moderate to Severe Intrauterine Adhesion: A Retrospective Cohort Study

The Top 100 Most Cited Articles on Intrauterine Adhesion: A Bibliometric Analysis

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