Intrauterine Perfusion of Autologous Platelet-Rich Plasma Before Frozen-Thawed Embryo Transfer Improves the Clinical Pregnancy Rate of Women With Recurrent Implantation Failure

Abstract

ObjectiveTo evaluate whether the intrauterine perfusion of platelet-rich plasma (PRP) before frozen-thawed embryo transfer (FET) improves the pregnancy outcomes of patients with repeated implantation failure (RIF).MethodsThis retrospective study included 288 infertile women with RIF after undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment from October 1, 2019, to January 1, 2021, at Qingdao Women and Children's Hospital. Patients were divided into two groups according to whether they received PRP intrauterine perfusion before embryo transfer in FET cycles. 138 women were in the PRP group, 150 women were in the control group. The primary outcome measure was live birth rates and the secondary outcome were clinical pregnancy, positive β hCG, miscarriage and implantation rates.ResultsNo significant differences in baseline demographic and clinical characteristics were observed between the two groups. Overall, significantly more women in the PRP group than in the control group achieved a live birth rate (41 women; 29.71% vs. 27 women; 18%) and a clinical pregnancy (50 women; 36.23% vs. 37 women; 24.67%). The PRP group had a higher implantation rate and lower spontaneous miscarriage rate than the control group, but these differences were not statistically significant. No pregnancy outcome difference between two groups in PCOS patients with RIF.ConclusionOur results showed that intrauterine perfusion of PRP before embryo transfer in FET cycles can significantly increase the live birth and clinical pregnancy rates in patients with RIF.

Recurrent implantation failure: A comprehensive summary from etiology to treatment

“…It has been reported that PRP can improve clinical pregnancy rates and endometrium thickness in patients with RIF ( 231 ). The benefit of PRP on implantation rates in patients with RIF has been confirmed by other studies ( Table 1 ) ( 232 , 233 , 243 ). Thus, PRP is a promising treatment option.…”

“…The release of platelet-derived growth factors, vascular endothelial growth factors, transforming growth factors, and epidermal growth factors from activated platelets results in angiogenesis, cell (231). The benefit of PRP on implantation rates in patients with RIF has been confirmed by other studies (Table 1) (232,233,243). Thus, PRP is a promising treatment option.…”

The value of platelet-rich plasma in women with previous implantation failure: a systematic review and meta-analysis

“…Tables S 2 and S 3 summarized the main characteristics of the included RCTs and non-RCTs. Twenty-seven studies were included in our analysis: 13 were RCTs [ 18 – 30 ], 5 was prospective cohort [ 17 , 31 – 35 ], 4 were prospective single-arm [ 35 – 38 ], and 5 were retrospective analysis [ 39 – 44 ]. All the studies were single centers except Kusumi [ 35 ], which was conducted in 7 fertility clinics.…”

Platelet-rich plasma treatment in patients with refractory thin endometrium and recurrent implantation failure: A comprehensive review

“…Xu et al [38] retrospectively evaluated 288 women with a RIF history (three or more consecutive failed embryo implantations with good-quality embryos, defined as at least six cleavage-stage embryos or three blastocysts). In total, 138 patients with PRP treatment and 150 patients who did not receive treatment were compared and the implantation, clinical pregnancy, and live birth rates were higher in the PRP group.…”