Intrauterine position modulates maternal behaviors in female mice

Kinsley, Craig Howard; Konen, C.; Miele, Joseph; Ghiraldi, Loraina; Svare, Bruce

doi:10.1016/0031-9384(86)90434-8

Cited by 36 publications

(12 citation statements)

References 27 publications

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“…In a related study, the proximity of a female fetus to one or two male fetuses alters the maternal responsiveness of that female when she becomes an adult. Contiguity of a female fetus to male fetuses increases the likelihood that the female will display reductions in maternal care as an adult (Kinsley et al, 1986; vom Saal and Bronson, 1978). That is, females developing in utero between two males display somewhat attenuated maternal care as an adult, presumably due to greater exposure to circulating androgens.…”

Section: Developmental Programming Of Maternal Carementioning

confidence: 99%

Neuroendocrine regulation of maternal behavior

Bridges¹

2015

Frontiers in Neuroendocrinology

280

207

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The expression of maternal behavior in mammals is regulated by the developmental and experiential events over a female’s lifetime. In this review the relationships between the endocrine and neural systems that play key roles in these developmental and experiential that affect both the establishment and maintenance of maternal care are presented. The involvement of the hormones estrogen, progesterone, and lactogens are discussed in the context of ligand, receptor, and gene activity in rodents and to a lesser extent in higher mammals. The roles of neuroendocrine factors, including oxytocin, vasopressin, classical neurotransmitters, and other neural gene products that regulate aspects of maternal care are set forth, and the interactions of hormones with central nervous system mediators of maternal behavior are discussed. The impact of prior developmental factors, including epigenetic events, and maternal experience on subsequent maternal care are assessed over the course of the female’s lifespan. It is proposed that common neuroendocrine mechanisms underlie the regulation of maternal care in mammals.

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Section: Developmental Programming Of Maternal Carementioning

confidence: 99%

Neuroendocrine regulation of maternal behavior

Bridges¹

2015

Frontiers in Neuroendocrinology

280

207

View full text Add to dashboard Cite

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“…In litter‐bearing species, fetuses are organized side by side in the uterine horns (91), and those not located at either end of the horns will be positioned between 2 females (0M), 2 males (2M), or 1 female and 1 male (1M) (91). Extensive IUP studies in mice have demonstrated profound effects of androgen exposure on developing female fetuses, influencing numerous phenotypes such as adult social behavior (93, 94), reproductive organ development (95, 96), and susceptibility to endocrine disruption (97). Notably, the degree to which androgen exposure influences the masculinization of females is genetically controlled as evidenced by the lack of an IUP effect noted for certain strains of inbred mice (98).…”

Section: Role Of Environment In Determining Sensitivity To Estrogensmentioning

confidence: 99%

The role of genetics in estrogen responses: a critical piece of an intricate puzzle

et al. 2014

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The estrogens are female sex hormones that are involved in a variety of physiological processes, including reproductive development and function, wound healing, and bone growth. They are mainly known for their roles in reproductive tissues-specifically, 17␤-estradiol (E 2 ), the primary estrogen, which is secreted by the ovaries and induces cellular proliferation and growth of the uterus and mammary glands. In addition to the role of estrogens in promoting tissue growth and development during normal physiological states, they have a well-established role in determining susceptibility to disease, particularly cancer, in reproductive tissues. The responsiveness of various tissues to estrogen is genetically controlled, with marked quantitative variation observed across multiple species, including humans. This variation presents both researchers and clinicians with a veritable physiological puzzle, the pieces of which-many of them unknown-are complex and difficult to fit together. Although genetics is known to play a major role in determining sensitivity to estrogens, there are other factors, including parent of origin and the maternal environment, that are intimately linked to heritable phenotypes but do not represent genotype, per se. The objectives of this review article were to summarize the current knowledge of the role of genotype, and uterine and neonatal environments, in phenotypic variation in the response to estrogens; to discuss recent findings and the potential mechanisms involved; and to highlight exciting research opportunities for the future.

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“…Apart from the potential benefits of holding more resources, masculinization in these species might also serve to prevent infanticide, because masculinized females are also more aggressive towards intruders during lactation (Kinsley et al . ).…”

Section: Discussionmentioning

confidence: 97%

“…We expected to find differences in the reproductive performance of females coming from female or male-biased litters. Indeed, it has been reported that females from male-biased litters were less likely to reproduce (Ryan & Vandenbergh 2002), might delay the onset of breeding (vom Saal & Bronson 1978) and/or have smaller litter sizes (Kinsley et al 1986). Moreover, we expected to find that litter sex composition under different density scenarios might represent an advantage or a disadvantage.…”

Section: Introductionmentioning

confidence: 99%

Long‐term effects of litter sex ratio on female reproduction in two iteroparous mammals

et al. 2014

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Summary1. Female mammals that develop in male-biased litters show signs of masculinization because they are exposed to the testosterone produced by their male siblings in utero. The early exposure to testosterone can affect female morphology, physiology, behaviour and life-history traits. 2. Masculinization is commonly seen as the collateral effect of developing in a male-biased litter. However, when resources are limiting, masculinization might be adaptive because androgenized females could monopolize resources. 3. We investigated whether females from male-biased litters, and therefore likely to be masculinized, showed adaptive advantages under different competing scenarios. For that, we used data from two long-term field projects studying yellow-bellied marmots (Marmota flaviventris Audubon and Bachman, 1841) and European rabbits (Oryctolagus cuniculus Linnaeus, 1758). We explored whether litter sex composition affected fitness-related reproductive traits: the onset of breeding, offspring production and the probability of reproduction in a given year. 4. Our study shows long-term consequences of litter sex composition on reproduction in European rabbits and yellow-bellied marmots. Females from male-biased litters from both species delayed the onset of breeding, suggesting the maladaptive nature of masculinization. However, in European rabbits, this effect was density-dependent. Under higher-density conditions, female rabbits from male-biased litters brought forward the onset of breeding, which might increase the probability of offspring overwinter survival and therefore their fitness. These females under limiting conditions might have a higher resource holding potential. 5. We conclude that prenatal maternal effects in natural populations should be taken into account when studying life-history variation. Moreover, it is notable that small variations in naturally occurring prenatal exposure to androgens have profound impacts on individuals, social groups and the population structure.

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Intrauterine position modulates maternal behaviors in female mice

Cited by 36 publications

References 27 publications

Neuroendocrine regulation of maternal behavior

Neuroendocrine regulation of maternal behavior

The role of genetics in estrogen responses: a critical piece of an intricate puzzle

Long‐term effects of litter sex ratio on female reproduction in two iteroparous mammals

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