Intrauterine pressure waveform characteristics of spontaneous and oxytocin- or prostaglandin F2α-induced active labor

Seitchik, Joseph; Chatkoff, Marvin L.; Hayashi, Robert H.

doi:10.1016/0002-9378(77)90457-4

Cited by 22 publications

(10 citation statements)

References 11 publications

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“…Although several authors have stated that uterine contractility following oral administration of PGE2 tablets is essentially comparable to that induced by intravenous oxytocin (4,5,17,28), there is at least theoretically a higher risk for hyperstimulation when an oxytocic compound is administered orally rather than intravenously (7,19,22,24,26,27,29,31). In our study signs of overstimulation, uncoordinated uterine contractility and/or uterine hypertonus were mainly seen when the PGE2 dose had been stepped up to 2.0 mg. Other studies have shown an increased frequency of gastrointestinal side effects with an individual dose of 1.5 mg or more (4,7,30,32).…”

Section: Discussionmentioning

confidence: 49%

Induction of Labor by Oral PGE₂ Administration—Evaluation of Different Dose Schedules

Bremme

Kindahl

Svanborg

1980

Acta Obstet Gynecol Scand

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The efficacy and safety of different oral doses of PGE, in tablet form were evaluated in 30 women admitted to the hospital for labor induction at or near term. The aim was to select a recommendable dose schedule based on recording of uterine contractility, clinical outcome and measurement of the resulting plasma levels of the two prostaglandin metabolites 15-keto-13.14-dihydro-PGE, and 15-keto-l3,14-dihydro-PGF, by gas-chromatography-mass spectrometry and by radio-immunoassay.Measurements of uterine contractility and of plasma levels of the PGE, metabolite both showed that the preferable interval between oral doses of PGE, tablets is one hour. Following 1 .O mg PGE,, the plasma concentra-7 42 40-43 4.1 3-6 c 15 6 42 40-43 5.0 2-1 *A=5, B = l O Acta Obstet Gynecol &and Suppl92

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Section: Discussionmentioning

confidence: 49%

Induction of Labor by Oral PGE₂ Administration—Evaluation of Different Dose Schedules

Bremme

Kindahl

Svanborg

1980

Acta Obstet Gynecol Scand

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“…This was also a reason why an assessment of the reproducibility of FVWs between contractions was not performed. The peak intrauterine pressure is similar in spontaneous and oxytocin‐provoked uterine contractions in labor, but oxytocin‐provoked contractions have a more rapid inotropic onset25 and a shorter duration26. Conversely, when three contractions per 10‐min window is achieved during the OCT the distribution pattern of contractions and the mean intrauterine pressure (40 mmHg) is similar to normal active‐phase labor27.…”

Section: Discussionmentioning

confidence: 95%

Uterine artery blood flow velocity waveforms during uterine contractions

Gudmundsson

Olofsson

2003

Ultrasound in Obstet & Gyne

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“…Natural prostaglandins (PG), such as PGFia and PGE2, have been suc cessfully used for the induction of labor at term [1,5,7] and for secondtrimester abortions [10]. For first-trimester abortions, however, these orig- inal PGs have not proven superior to surgical evacuation of the uterine cavity, mainly because of systemic side effects [2], Along with a variety of PG analogues interest has been focused recently toward a new PG deriva tive, 16-phenoxy-PGE2-methylsulfonylamide (Sulprostone) ( fig.…”

Section: Introductionmentioning

confidence: 99%

HCG, Progesterone and 17-Beta-Estradiol Levels during Extra-Amniotically Induced Early Abortion by a New Prostaglandin Derivative (Sulprostone)

Nilsson¹,

Zador²,

Nygren³

et al. 1981

Gynecol Obstet Invest

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A new prostaglandin E₂ derivative (Sulprostone) was given extra-amniotically to 17 healthy women, who were 7–8 weeks pregnant, in order to assess the plasma profile of HCG, 17Β-estradiol (E₂), and progesterone and to evaluate the effectiveness and overall acceptability of the method in relation to different dose levels. On the lowest dose level (5 µg) only 3 of 7 patients aborted within a 3– to 6–day period. At higher dose levels (10 and 15 µg, respectively) 9 out of 10 women exhibited clinical evidence of an abortion. In the group who aborted, E₂, progesterone, and HCG decreased continuously, whereas in the nonabortion group decreased levels were found 3 and 6 h after administration of the drug, but already after 24 h the values had again increased. Practically all treated women experienced lower abdominal discomfort, 7 (41 %) reported the pains being severe. Vomiting and/or diarrhea occurred in 4 patients (24%). Similarly to other hitherto tested prostaglandins in humans, this new analogue exhibits its effect primarily through direct stimulatory effect on the uterine smooth muscle, resulting in subsequent decline in the concentrations of HCG, E₂, and progesterone. In the group of successful inductions the decrease of the HCG concentration was close the half-time of HCG, indicating a permanent damage to the placenta. Despite the high success rate at a dose of 10 µg or more, the side effects, mainly abdominal cramps, were too severe to make this method feasible for the induction of early abortion when comparing to the available routine procedure of rapid vacuum curettage used on an outpatients basis.

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Intrauterine pressure waveform characteristics of spontaneous and oxytocin- or prostaglandin F2α-induced active labor

Cited by 22 publications

References 11 publications

Induction of Labor by Oral PGE₂ Administration—Evaluation of Different Dose Schedules

Induction of Labor by Oral PGE₂ Administration—Evaluation of Different Dose Schedules

Uterine artery blood flow velocity waveforms during uterine contractions

HCG, Progesterone and 17-Beta-Estradiol Levels during Extra-Amniotically Induced Early Abortion by a New Prostaglandin Derivative (Sulprostone)

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Intrauterine pressure waveform characteristics of spontaneous and oxytocin- or prostaglandin F2α-induced active labor

Cited by 22 publications

References 11 publications

Induction of Labor by Oral PGE2 Administration—Evaluation of Different Dose Schedules

Induction of Labor by Oral PGE2 Administration—Evaluation of Different Dose Schedules

Uterine artery blood flow velocity waveforms during uterine contractions

HCG, Progesterone and 17-Beta-Estradiol Levels during Extra-Amniotically Induced Early Abortion by a New Prostaglandin Derivative (Sulprostone)

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Induction of Labor by Oral PGE₂ Administration—Evaluation of Different Dose Schedules

Induction of Labor by Oral PGE₂ Administration—Evaluation of Different Dose Schedules