Intrauterine sensitization of allergen-specific IgE analyzed by a highly sensitive new allergen microarray

Kamemura, Norio; Tada, Hitomi; Shimojo, Naoki; Morita, Yoshinori; Kohno, Yoichi; Ichioka, Takao; Suzuki, Koichi; Kubota, Kenji; Hiyoshi, Mineyoshi; Kido, Hiroshi

doi:10.1016/j.jaci.2012.02.023

Cited by 60 publications

(51 citation statements)

References 32 publications

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“…Intrauterine sensitization to milk, egg, and peanut has been reported , Kamemura et al 2012. However, evidence is lacking to support that maternal diet during pregnancy/lactation can affect development of clinical food allergy in infants (Berin & Sampson 2013, Netting et al 2014).…”

Section: Exposure To Food Allergens Sensitizationmentioning

confidence: 99%

Food Allergy

Sathe

Liu

Zaffran

2016

Annu. Rev. Food Sci. Technol.

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Food allergy is receiving increased attention in recent years. Because there is currently no known cure for food allergy, avoiding the offending food is the best defense for sensitive individuals. Type I food allergy is mediated by food proteins, and thus, theoretically, any food protein is a potential allergen. Variability of an individual's immune system further complicates attempts to understand allergen-antibody interaction. In this article, we briefly review food allergy occurrence, prevalence, mechanisms, and detection. Efforts aimed at reducing/eliminating allergens through food processing are discussed. Future research needs are addressed.

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Section: Exposure To Food Allergens Sensitizationmentioning

confidence: 99%

Food Allergy

Sathe

Liu

Zaffran

2016

Annu. Rev. Food Sci. Technol.

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“…In fact, it has been speculated that IgE may be already produced by foetuses in early pregnancy and can be detected in cord blood [33].…”

Section: Introductionmentioning

confidence: 99%

Cow’s milk allergy: From allergens to new forms of diagnosis, therapy and prevention

Hochwallner

Schulmeister

Swoboda

et al. 2014

Methods

206

159

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The first adverse reactions to cow’s milk were already described 2000 years ago. However, it was only 50 years ago that several groups started with the analysis of cow’s milk allergens. Meanwhile the spectrum of allergy eliciting proteins within cow’s milk is identified and several cow’s milk allergens have been characterized regarding their biochemical properties, fold and IgE binding epitopes. The diagnosis of cow’s milk allergy is diverse ranging from fast and cheap in vitro assays to elaborate in vivo assays. Considerable effort was spent to improve the diagnosis from an extract-based into a component resolved concept. There is still no suitable therapy available against cow’s milk allergy except avoidance. Therefore research needs to focus on the development of suitable and safe immunotherapies that do not elicit severe side effect.

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“…Therefore it has been hypothesized that priming may occur through a nonoral route, one of which may be in utero exposure. Discordant measures of allergen-specific IgE in cord blood, newborn blood, and maternal blood using ultrasensitive allergen microarrays support the hypothesis that IgE sensitization can occur in utero (Kamemura et al, 2012). However, there is currently insufficient clinical evidence on the impact of maternal ingestion of food allergens during pregnancy and lactation to make any dietary recommendations (Greer et al, 2008).…”

Section: In Utero Allergen Exposurementioning

confidence: 99%