Intrauterine Stroke and Maternal Polydrug Abuse

Tenorio, Gene M.; Nazvi, Mubariz; Bickers, Gayle H.; Hubbird, Robert H.

doi:10.1177/000992288802701110

Cited by 28 publications

(8 citation statements)

References 10 publications

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“…72 In a study of 14 cocaine‐only and 18 cocaine‐plus‐alcohol infants, Fries et al 73 reported a general finding of abnormal auditory brainstem responses in such infants, but provided no descriptive details. The cocaine‐exposed infant described by Tenorio et al 52 had an abnormal auditory brainstem response. We, too, have observed abnormal auditory brainstem responses in neonates prenatally exposed to cocaine and/or alcohol.…”

Section: Hearing Disordersmentioning

confidence: 94%

“…These disturbances persisted in six infants beyond the age of 4 months. Tenorio et al 52 described an infant who had an in utero stroke and resulting porencephaly as a consequence of the mother's cocaine abuse. The infant had an abnormal visual evoked potential as well as an abnormal auditory brainstem response and electroencephalogram.…”

Section: Visual Disordersmentioning

confidence: 99%

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Effects of Prenatal Cocaine on Hearing, Vision, Growth, and Behavior^a

Church

Crossland

Holmes

et al. 1998

Annals of the New York Academy of Sciences

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The illicit use of cocaine has increased dramatically over the last 10-12 years. There has been a corresponding increase in cocaine abuse among obstetric patients and in the number of "cocaine babies." According to some estimates, these children make up more than half of the drug-associated births. This problem is therefore a major public health concern. Consequently, our laboratory investigated the effects of prenatal cocaine exposure on hearing, vision, growth, and exploratory/stress behavior. This chapter summarizes the literature on animals and humans on these topics and presents new observations from our laboratory. In terms of maternal toxicity, prenatal cocaine exposure causes hypertension, placental abruption, spontaneous abortion, poor pregnancy weight gain, and undernutrition secondary to appetite suppression. Some offspring effects include in utero growth retardation, cephalic hemorrhage, fetal edema, altered body composition, congenital malformations, and even pre- and postnatal death. The offspring can also exhibit a variety of behavioral, visual, hearing, and language disorders. Differential effects of animal strain and late gestational cocaine exposure are discussed. Comparisons are made between prenatal cocaine, the fetal alcohol syndrome, and the effects of prenatal undernutrition. Recommendations for clinical assessment and intervention are made.

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Section: Hearing Disordersmentioning

confidence: 94%

Section: Visual Disordersmentioning

confidence: 99%

Effects of Prenatal Cocaine on Hearing, Vision, Growth, and Behavior^a

Church

Crossland

Holmes

et al. 1998

Annals of the New York Academy of Sciences

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“…65,66 In animal models, cocaine and its metabolites exert a vasoconstrictive effect on fetal cerebral vasculature resulting in decreased cerebral blood flow. 67 However, both direct and indirect mechanisms are invoked in the genesis of neonatal stroke related to fetal cocaine exposure.…”

Section: Strokesmentioning

confidence: 99%

Fetal Alcohol and Drug Effects

Chiriboga¹

2003

The Neurologist

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Most adverse effects of prenatal drug exposure are self-limited, with catch-up growth and resolution of withdrawal and of prior neurobehavioral abnormalities noted over time. The exception is alcohol, which is linked to life-long impairments (i.e., mental retardation and microcephaly) and possibly cigarette-related behavioral effects. The absence of tangible evidence of detrimental long-term cocaine effects may reflect limitations in the methodology used to identify children at greatest risk for adverse outcome.

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“…Review of the malformations and other medical problems attributed by our participants to cocaine in an open-ended questionnaire reveals cardiac and CNS malformations as well as addiction and dependence as the most common by both physicians and the public; none of these has been scientifically validated and there is no known "neonatal addiction" to cocaine. Several physicians mentioned medical problems quoted to be associated with maternal cocaine use based on case reports, such as cerebral infarct and (Tenorio et al, 1988;Chasnoff et al, 1986) intestinal atresia; however, these have not yet been proven by population-based studies (Lutiger et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

The perception of teratogenic risk of cocaine

et al. 1992

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While there has been a substantial increase in recreational use of cocaine by young adults, conclusive evidence for cocaine teratogenicity in humans is lacking, and even those believing the drug is teratogenic agree that the rates are quite small. While counseling pregnant women on their teratogenic risk, it was our impression that there is an unrealistically high perception of reproductive risk of cocaine. We wished to quantify the perception of teratogenic risk of cocaine by the public, physicians, and by pregnant women who were counseled following gestational exposure to the drug. Women taking cocaine during the first trimester of pregnancy (n = 54), controls with post secondary education (n = 30), and physicians (n = 30) were asked, using a visual analogue scale, to quantify the teratogenic risk of cocaine and the tendency to terminate/continue the pregnancy after first trimester exposure; in the case of the "public" and physicians this was a hypothetical question. Both physicians and the controls perceived cocaine to be teratogenic (13.4 +/- 11% risk of major malformations by physicians, and 56.5 +/- 22.8% by the "public"). The controls believed cocaine to be as hazardous as thalidomide (57.2 +/- 25.6% risk for thalidomide). Asked whether they would wish to terminate such pregnancy in their family, most physicians (56%) and the controls (70%) had a greater than 50% tendency to terminate.(ABSTRACT TRUNCATED AT 250 WORDS)

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Intrauterine Stroke and Maternal Polydrug Abuse

Cited by 28 publications

References 10 publications

Effects of Prenatal Cocaine on Hearing, Vision, Growth, and Behavior^a

Effects of Prenatal Cocaine on Hearing, Vision, Growth, and Behavior^a

Fetal Alcohol and Drug Effects

The perception of teratogenic risk of cocaine

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Intrauterine Stroke and Maternal Polydrug Abuse

Cited by 28 publications

References 10 publications

Effects of Prenatal Cocaine on Hearing, Vision, Growth, and Behaviora

Effects of Prenatal Cocaine on Hearing, Vision, Growth, and Behaviora

Fetal Alcohol and Drug Effects

The perception of teratogenic risk of cocaine

Contact Info

Product

Resources

About

Effects of Prenatal Cocaine on Hearing, Vision, Growth, and Behavior^a

Effects of Prenatal Cocaine on Hearing, Vision, Growth, and Behavior^a