Intrauterine Transfusion in the Management of Severe Rhesus Isoimmunization

Robertson, Euan G.; Brown, Angela; Ellis, Matthew; Walker, William O.

doi:10.1111/j.1471-0528.1976.tb00915.x

Cited by 35 publications

(3 citation statements)

References 6 publications

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“…Amniographic techniques have caused 20% fetal mortality per transfusion in the experience of some authors [14]. BOWMAN reported a 16.4 per 100 L U. T.s of fetal traumatic deaths [2]; whereas HARMAN et al from the same center but on the basis of a more recent experience report no failures or traumatic deaths [12].…”

Section: Discussionmentioning

confidence: 99%

Ultrasound contributions to the management of the severely isoimmunized fetus

Buscaglia¹,

Ferrazzi²,

Zuliani³

et al. 1986

Journal of Perinatal Medicine

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Section: Discussionmentioning

confidence: 99%

Ultrasound contributions to the management of the severely isoimmunized fetus

Buscaglia¹,

Ferrazzi²,

Zuliani³

et al. 1986

Journal of Perinatal Medicine

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“…The procedure of intra-uterine transfusion has never been tested by acontrolled trial and various papers have questioned whether it has been of over-all benefit (Palmer andGordon 1976, Robertson et al 1976). There is little doubt that, while successful in individual patients, others (perhaps 20 per cent) have been killed by the procedure (Robertson et al 1976). Some series report an over-all survival rate of between 40 and 50 per cent (Girling et al 1972, Richings 1973.…”

Section: Discussionmentioning

confidence: 99%

Follow‐up Study of Survivors after Intra‐uterine Transfusion

Ellis

1980

Develop Med Child Neuro

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SUMMARY Between 1965 and 1976 a total of 217 infants received intra‐uterine transfusions. Perinatal and follow‐up data are presented on the 81 survivors, of whom 62 per cent were over five years of age at final follow‐up. Assessment included development and general health, audiometric testing and school performance. Abnormalities were found in 29 of the survivors. In 13 cases these were attributed to haemolytic disease, and all had some neurological deficit such as differing degrees of deafness. 10 others had slight abnormalities associated with the procedure of intra‐uterine transfusion, while six had abnormalities not associated with either (spastic quadriplegia following infection, congenital heart disease and visual disorders). The remaining 52 children were normal. It is suggested that hyperbilirubinaemia is probably responsible for the neurological deficits. RÉSUMÉ Etude longitudinale des enfants survivants après transfusion intra‐utérine Entre 1965 et 1976, 217 nourrissons one bénéficié de transfusions intra‐utérines. Les données périnatales et de suite sont indiquées pour les 81 survivants, dont 62 pour cent étaient âgés de plus de cinq ans à la fin de 'étude longitudinale. 'appréciation a inclus de développement et la santé générate, des tests 'audition et de performance scolaire. Des anomalies one été trouvées chez 29 des survivants. Dans 13 cas, elles ont été attribuées à une maladie hémolytique et chacun présentait quelque déficit neurologique tel qu'une surditéà differents degrés. Dix autres sujets présentaient des anomalies légères associées au procédé de transfusion intre‐utérine, tandis que six autres sujets avaient des anomalies légères non associées à ce procédé (quadriplégie spastiqiie à la suite 'injection, affection cardiaque congénitale et troubles visuels). Les 52 autres enfants étaient normaux. II est suggéré que 'hyperbilirubinémie est probablement responsable des déficits neurologiques. ZUSAMMENFASSUNG Nachuntersuchungen von Überlebenden, die eine intra‐uterine Transfusion bekommen hatten In dem Zeitraum von 1965 bis 1976 erhielten 217 Kinder eine intra‐uterine Transfusion wegen einer hämolytischen Erkrankung. Von den 81 Überlebenden, von denen 62 Prozent bei der letzten Kontrolluntersuchung über funf Jahre alt waren, werden die Daten der Perinatal‐und Nachuntersuchungsperiode wiedergegeben. Bei der Beurteilung wurden Entwicklung, allgemeiner Gesundheitszustand, Hörvermögen und Schulleistungen berücksichtigt. Bei 29 Überlebenden wurden Normabweichungen festgestellt. Bei 13 waren diese durch die hämolytische Erkrankung bedingt und alle waren in irgendeiner Weise neurologisch auffällig und hatten z.B. unterschiedliche Grade einer Hörstörung. 10 andere hatten leichte Mißbildungen, die mit der Methodik der intra‐uterinen Austauschtransfusion zusammenhingen, wahrend sechs Störungen aufwiesen, die weder mit dem einen noch mit dem anderen zusammenhingen (spastische Teraplegie nach Infektionen, kongenitale Herzerkrankungen und Sehstörungen). Die restlichen 52 Kinder waren normal. Es wird angenom...

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“…The procedure can be started as early as 21 to 22 weeks of gestation and can be repeated if necessary. In early published series, overall survival rates were 24 to 56 per cent [6, 51,52], In later studies, perinatal survival rates of up to 92 per cent have been reported [44,46,53,54,55]. In hydropic fetuses and in fetuses with a gestational age lower than 26 weeks the results were very poor.…”

Section: Therapymentioning

confidence: 99%

Diagnosis and treatment of severe alloimmunization

Gravenhorst¹

1994

Vox Sanguinis

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Intrauterine Transfusion in the Management of Severe Rhesus Isoimmunization

Cited by 35 publications

References 6 publications

Ultrasound contributions to the management of the severely isoimmunized fetus

Ultrasound contributions to the management of the severely isoimmunized fetus

Follow‐up Study of Survivors after Intra‐uterine Transfusion

Diagnosis and treatment of severe alloimmunization

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