Intravaginal clindamycin treatment for bacterial vaginosis: Effects on preterm delivery and low birth weight

Joesoef, M R; Hillier, Sharon L.; Wiknjosastro, Gulardi Hanifa; Sumapouw, H.; Linnan, Michael; Norojono, W.; Idajadi, A; Utomo, Budi

doi:10.1016/0002-9378(95)90644-4

Cited by 170 publications

(93 citation statements)

References 18 publications

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“…Bacterial vaginosis is often asymptomatic, and its diagnosis is inexpensive yet needs technical skill. Failure to detect BV early constitutes a major risk factor for the acquisition of other sexually transmitted infections as previously reported (Joesoef et al, 1995;Cherpes et al, 2003).…”

Section: Discussionmentioning

confidence: 65%

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Prevalence of Bacterial Vaginosis Among Sexually Active Women Attending the CDC Central Clinic Tiko, South West Region, Cameroon

Akomoneh¹,

Fumoloh²,

Aseneck³

et al. 2016

AJID

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Background: Bacterial vaginosis (BV) is a polymicrobial, superficial vaginal infection involving a reduction in the amount of hydrogen peroxide-producing Lactobacillus and overgrowth of anaerobic bacteria. Common symptoms include increased fishy smelling vaginal discharge which is usually white or gray in color. Burning with urination may occur and itching is uncommon. Risk factors include douching, new or multiple sex partners, antibiotics, and use of intrauterine device among others. Materials and Methods:This cross-sectional study assessed the prevalence of bacterial vaginosis among sexually active women aged 15-45 years. Vaginal swabs were obtained with the use of sterile swab sticks which were later smeared on clean glass slides and then Gram stained. The stained smears were observed for bacterial morphotypes with the X100 oil immersion objective and the Nugent scoring system was used to determine BV. Data were analyzed using the Statistical Package for Social Scientists (SPSS) version 17.0 and were considered significant at p ≤ 0.05. Results: A total of 100 women participated in the study with the overall prevalence of BV rated 38%. The prevalence of BV with respect to associated factors was also investigated and it was observed that BV was more prevalent in the age groups 20-25 (48.1%) and 25-29 (44.4%), those who had attained only primary education (60.5%), married women, (68.4%), pregnant women (71.0%), and women who practiced vaginal douching, (97.4%). However, no statistical significant difference was observed in the prevalence between these parameters (P > 0.05). Conclusions: Conclusively, the prevalence of bacterial vaginosis in our study population is 38% and highest among women aged between 25 and 34 years, pregnant women, married women, less educated women and women who practiced poor vaginal hygiene.

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Section: Discussionmentioning

confidence: 65%

“…The incidence of BV has also been associated with a greater occurrence of other sexually transmitted infections like HIV and cytomegalovirus (Joesoef et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Bacterial Vaginosis Among Sexually Active Women Attending the CDC Central Clinic Tiko, South West Region, Cameroon

Akomoneh¹,

Fumoloh²,

Aseneck³

et al. 2016

AJID

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“…The authors proposed that the increased frequency of preterm delivery might be caused by a transient increase in vaginal colonization by Escherichi coli and Enterococcus 1 month after therapy. Since E. coli is linked to an increased risk of preterm delivery, this may explain the value of 15%, compared with the 13.5% difference found in the study by Joesoef et al 12 .…”

mentioning

confidence: 64%

“…However, since the clinical diagnosis of BV need not be symptomatic, screening all pregnant women who have risk factors may be unnecessary and not cost-effective 21 , while the most advantageous time to screen and the optimum dosage of antibiotic is uncertain. 7 Morales et al 9 McGregor et al 1 McDonald et al 10 Cochrane database 3 Joesoef et al 12 Carey et al…”

Section: Discussionmentioning

confidence: 99%

The Effect of Treating Bacterial Vaginosis on Preterm Labor

Tebes

Lynch

Sinnott

2003

Infectious Diseases in Obstetrics and Gynecology

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Objective: Multiple studies suggest that bacterial vaginosis (BV) causes preterm labor; yet its routine treatment remains controversial. In order to help to elucidate this controversy, we performed a thorough review of studies with levels of evidence ranging from I to II-II. Methods:We searched for all of the studies from the years 1994 to 2001 via Medline's database, including MD Consult and Ovid Mednet. Results: Several trials discovered a decrease in the incidence of preterm labor when BV was treated, but most of those trials were performed on women with a history of preterm labor. However, the majority of trials reviewed advise against treatment of a general low-risk obstetric population, as there was no significant decrease in preterm labor. Conclusions: Therefore, based on the above studies and the current guidelines of the Centers for Disease Control and Prevention (CDC), treating pregnant women in high-risk populations who are diagnosed with BV provides the clinician with an opportunity to possibly prevent preterm labor in this population. In nulliparous women without a history of preterm birth, treatment is recommended if other risk factors are present (e.g. gonorrhea or chlamydia). However, in the general low-risk populations, routine screening is not indicated.

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“…Thus, topical treatment might work best in the first trimester of pregnancy. Two studies reported non-significant trends for women receiving clindamycin cream to have a greater rate of preterm birth or low birth weight infants than those receiving placebo [38,39]. In contrast, a multicentre UK study has shown a 50% reduction in preterm birth for clindamycin cream with borderline statistical significance (R. F. Lamont, personal communication).…”

Section: Treatment In Pregnancymentioning

confidence: 99%

Sexually transmitted diseases: microbiology and management Proceedings of the Seventh Liverpool Tropical School Bayer Symposium on Microbial Disease held on 6 February 2000

Birley¹,

Duerden

2002

Journal of Medical Microbiology

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Intravaginal clindamycin treatment for bacterial vaginosis: Effects on preterm delivery and low birth weight

Cited by 170 publications

References 18 publications

Prevalence of Bacterial Vaginosis Among Sexually Active Women Attending the CDC Central Clinic Tiko, South West Region, Cameroon

Prevalence of Bacterial Vaginosis Among Sexually Active Women Attending the CDC Central Clinic Tiko, South West Region, Cameroon

The Effect of Treating Bacterial Vaginosis on Preterm Labor

Sexually transmitted diseases: microbiology and management Proceedings of the Seventh Liverpool Tropical School Bayer Symposium on Microbial Disease held on 6 February 2000

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