“…Consequently, the volumes of test media used for in vitro drug release experiments with macaque-sized IVRs are often significantly smaller than those used in human IVR experiments [24,37,38,39,40]. The reported agitation speeds in shake-flask experiments range from 60 rpm [31,35,36,37,38,39,40,41,42,43,44,45,46,47,48,70,75,78,79,80] through 80 rpm [51,52,53,54,73], 100 rpm [10,56,57,58,71] and 110 rpm [17] to 130 rpm [34,49,50,81,82].…”