Intravasales Volumen und Strömungswiderstand des großen und kleinen Kreislaufs unter der Wirkung von Nitroglycerin

Hagemann, K; Niehues, B; Arnold, G; Lochner, W.

doi:10.1007/978-3-642-85288-6_46

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…6 mg Nitroglycerin infundiert waren. Bei Patienten mit einem Vorderwandinfarkt (n = 5) wurde die ST-Streckenabweichung in den Ableitungen aVL, I und in allen18 Brustwandableitungen, bei Patienten mit einem Hinterwandinfarkt (n = 7) in allen Extremitätenableitungen und in allen 18 Brustwandableitungen nach einer nach Nielsen und Mitarbeitern (27) modifizierten Methode ausgemessen. Die positive oder negative Abweichung der ST-Strecke von der als isoelektrischen Linien gewählten TP-Strecke wurde 0,1 s nach dem Fußpunkt der 5-Zacke oder, bei deren Fehlen, der Q-S-Zacke gemessen.…”

unclassified

Wirkung von Nitroglycerin beim akuten Myokardinfarkt. II. Intravenöse Dauerinfusion von Nitroglycerin bei Patienten mit und ohne Linksinsuffizienz und ihre Auswirkungen auf die Infarktgröße

Bussmann¹,

Schöfer²,

Kaltenbach³

1976

Dtsch med Wochenschr

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Twenty-four patients with acute myocardial infarction were divided into two groups according to left-ventricular filling pressure (LVFP): group I (n = 13) with LVFP less than 20 mm Hg, group II (n = 11) with LVFP greater than 20 mm HG. After infusion of 3 mg nitroglycerin in the first and 6 mg in the second hour there was a highly significant decrease in the filling pressure (from 15 to 9 mm Hg in group I, 28 to 16 mm Hg in group II). Mean arterila pressure fell in both groups by an average of 9 mm Hg. There were only slight changes in heart rate. Cardiac output fell from 4.4 to 3.9 1/min in group I, while it rose significantly (from 3.5 to 4.0 1/min) in group II from an initially markedly decreased level. In patients of group II the subjective symptoms improved with positive changes in the haemodynamic variables. Electrocardiographic precordial mapping indicated that nitromapping indicated that nitroglycerin at a dose of 3 mg/h diminished the zone of ischaemia, while at a dose of 6 mg/h S-T elevations and depressions increased again.

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Wirkung von Nitroglycerin beim akuten Myokardinfarkt. II. Intravenöse Dauerinfusion von Nitroglycerin bei Patienten mit und ohne Linksinsuffizienz und ihre Auswirkungen auf die Infarktgröße

Bussmann¹,

Schöfer²,

Kaltenbach³

1976

Dtsch med Wochenschr

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“…More recent investigations have shown that the reduction in blood pressure is caused mainly by an increase in the dilatability of the postcapillary vasculature. Increased peripheral capacity leading to a decrease in venous reflux seems to cause the drop in the end-diastolic pressure and volume of the heart [28,30,31].…”

Section: Nitroglycerinmentioning

confidence: 99%

Nitroprusside‐ and nitroglycerin‐induced hypotension: Effects on hemodynamics and on the microcirculation

et al. 1982

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After a short summary of the effects and metabolism of sodium nitroprusside (SNP) and nitroglycerin (NTG), the influence of induced hypotension on hemodynamics and on the microcirculation is investigated. The continuous registration of the local tissue pO2 in skeletal muscle, myocardium, and liver with the multiwire surface electrode provides the opportunity to recognize immediately a change in the microcirculatory bed. This new method shows in animal experiments that the local oxygen supply during SNP‐induced hypotension is dramatically reduced, while the arterial pO2 remains in a normal range. These changes are not found during NTG‐induced hypotension. Electron microscopic examination of various organs, and especially of the myocardium, shows that the alterations of the oxygen supply found after application of SNP were connected with changes in the ultrastructure.

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“…1m Abstand von je 5 Minuten erhielt der Patient weitere fünfmal je 1,6 Wie die klinischen und hämodynamischen Ergebnisse zeigen, entfaltet Nitroglycerin beim Lungenödem eine rasche durchschlagende Wirkung. Die Hauptwirkung kommt über das peripher-venöse System zustande (11,13,18). Wie Untersuchungen von Raff und Lochner (16) gezeigt haben, bewirkt Nitroglycerin eine Dilatation des venösen Systems und damit eine Zunahme der venösen Kapazität.…”

Section: Diskussionunclassified

Wirkung von Nitroglycerin sublingual in der Notfalltherapie des klassischen Lungenödems

Bussmann¹,

Schupp²

1977

Dtsch med Wochenschr

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Of 22 patients with the classical clinical signs of pulmonary oedema (orthopnoe, cyanosis, sweating and rales heard at a distance) 15 (Group A) were observed clinically, while seven (Group B) underwent haemodynamic studies. Those in Group A were given 0.8-2.4 mg nitroglycerin sublingually one to six times at 5--10 minute intervals. Within five minutes of nitroglycerin administration 7 of the 15 had their first signs of clinical improvement. In 11 patients the rales had disappeared after 15--20 minutes or had regressed. In the remainder the dyspnoea had decreased so that at this point in 14 of the 15 patients various degrees of improvement had occurred. Four patients were completely without clinical signs after 30 minutes. The increased arterial blood pressure and heart rate had fallen markedly. In the seven patients of Group B mean left ventricular filling pressure fell within ten minutes of nitroglycerin administration (1.6 mg) from 33 +/- 10 to 24 +/- 8 mmHg, cardiac output rising sifnificantly from 3.3 +/- 0.8 to 3.7 +/- 0.8 1/min. Such favourable results with nitroglycerin are to be expected only if the pulmonary oedema is of cardiac origin.

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Intravasales Volumen und Strömungswiderstand des großen und kleinen Kreislaufs unter der Wirkung von Nitroglycerin

Cited by 6 publications

References 14 publications

Wirkung von Nitroglycerin beim akuten Myokardinfarkt. II. Intravenöse Dauerinfusion von Nitroglycerin bei Patienten mit und ohne Linksinsuffizienz und ihre Auswirkungen auf die Infarktgröße

Wirkung von Nitroglycerin beim akuten Myokardinfarkt. II. Intravenöse Dauerinfusion von Nitroglycerin bei Patienten mit und ohne Linksinsuffizienz und ihre Auswirkungen auf die Infarktgröße

Nitroprusside‐ and nitroglycerin‐induced hypotension: Effects on hemodynamics and on the microcirculation

Wirkung von Nitroglycerin sublingual in der Notfalltherapie des klassischen Lungenödems

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