Intravascular bronchioloalveolar tumor

Miettinen, Markku; Collan, Yrjö; Halttunen, P; T, Maamies; Vilkko, Pekka

doi:10.1002/1097-0142(19871115)60:10<2471::aid-cncr2820601021>3.0.co;2-8

Cited by 54 publications

(27 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regarding therapy in PEH, surgical resection seems to be the treatment of choice, whenever the PEH lesion is solitary or the number of lesions is limited [9,13,31]. All three PEH patients with a solitary lesion of PEH in this study are alive after surgical resection, with a mean follow-up of 44 months (see Overall prognosis section).…”

Section: Discussionmentioning

confidence: 87%

“…The longest survivor of PEH was a female patient reported by MIETTINEN et al [31]. The patient un-derwent 13 operations, including 11 thoracotomies bet-ween the age of 17-41 yrs.…”

Section: Discussionmentioning

confidence: 98%

“…The spread through the airspaces of the lung is continuous [2,9]. Although rare, distant metastases of the liver, skin, kidney, spleen and retroperitoneum can occur, presumably via the bloodstream [2,26,31]. In contrast, three patients were asymptomatic and had multiple bilateral pulmonary nodules.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Pulmonary epithelioid haemangioendothelioma in 21 patients, including three with partial spontaneous regression

Kitaichi¹,

Nagai²,

Nishimura³

et al. 1998

Eur Respir J

221

272

View full text Add to dashboard Cite

aaPulmonary epithelioid haemangioendothelioma (PEH) is a rare tumour of the lung. The disease was originally reported by DAIL and LIEBOW [1] in 1975 as "intravascular bronchoalveolar tumour" (IVBAT), and the majority (65%) patients of the reported 20 patients showed multiple bilateral nodular lesions. In addition, one patient had bronchoalveolar cell carcinoma. The recognition of Weibel-Palade bodies in the cytoplasm of tumour cells of IVBAT by electron microscopy, along with the immunoreactivity of the cytoplasm of tumour cells for factor VIII-related antigen, prompted the realization that IVBAT probably derived from vascular endothelial cells [2][3][4][5][6][7][8][9]. Forty-one patients with soft-tissue neoplasms exhibiting histopathological features similar to IVBAT were reported by WEISS and ENZINGER [10] in 1982. The tumour was termed epithelioid haemangioendothelioma [2,[9][10][11][12], and by 1986 had been reported to occur also in the liver, head and neck area, oral mucosa, bone, mediastinum, diaphragm and brain [13].We reported on two asymptomatic patients with IVBAT (PEH) in the mid-1980s [14,15], and observed partial spontaneous regression of the disease during follow-up in both. In order to evaluate more thoroughly the clinicopathological spectrum of PEH, 21 patients with PEH recruited in Asia (Japan, Korea, Taiwan and Singapore) were studied, who included an additional patient with partial spontaneous regression [16]. The description of all of these patients and their prognostic features form the basis of the present report. Methods Study populationTo obtain data on the clinical and pathological features of PEH in as many patients as possible, a survey was carried out of the Japanese literature of the past 15 yrs and letters were sent to Departments of Medicine, Respiratory Medicine, Radiology and Pathology of 230 major hospitals in Japan. In addition, letters were sent to five major hospitals in Korea, Taiwan, Hong Kong and Singapore. In order to confirm the diagnosis of PEH, the histopathological specimens from 23 patients were reviewed at an International Meeting on PEH held in 1994 in Kyoto, Japan. Six out of the 23 patients have been reviewed previously by one of the present authors (M. Kitaichi) [14][15][16][17].The clinical summary of patients with PEH focused on the features described in the Results section at the time of the first examination by their primary physicians (see Acknowledgements) and at the time of the last clinical contact.The patients were also questioned about the type and duration of therapy, if any. The clinical onset of PEH was defined as the time of onset of pulmonary symptoms attributable to the disease. Clinical improvement or deterioration was assessed by chest radiography. Histopathological and immunohistochemical studiesHistopathological features were analysed according to 18 items [2,9]. The cellularity of tumour cells was graded from Pulmonary epithelioid haemangioendothelioma in 21 patients, including three with partial spontaneous regression. M. Kitaichi, S. Nag...

show abstract

Section: Discussionmentioning

confidence: 87%

“…The longest survivor of PEH was a female patient reported by MIETTINEN et al [31]. The patient un-derwent 13 operations, including 11 thoracotomies bet-ween the age of 17-41 yrs.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Pulmonary epithelioid haemangioendothelioma in 21 patients, including three with partial spontaneous regression

Kitaichi¹,

Nagai²,

Nishimura³

et al. 1998

Eur Respir J

221

272

View full text Add to dashboard Cite

show abstract

“…The centre of the nodule is typically sclerotic, necrotic and hypocellular and it may resemble an infarct, a microabscess, a hyalinised granuloma or even a hamartoma. The periphery of the nodule is composed of an hypercellular and sclerotic stroma and clusters of neoplastic cells with few morphological signs of malignancy that grow as polypoid tufts into alveolar spaces [2,4,5,10,11]. Many autoimmune and infectious processes can produce a similar pathological picture of central coagulative necrosis and atypical endothelial and intra-alveolar cell growth, so all these causes should be ruled out before a definitive diagnosis is made [12].…”

Section: Case Reportmentioning

confidence: 99%

Central nervous system metastases of a pulmonary epitheloid haemangioendothelioma

Díaz

Segura²,

Calderero³

et al. 2004

Eur Respir J

View full text Add to dashboard Cite

Central nervous system metastases of a pulmonary epitheloid haemangioendothelioma. R. Díaz, Á. Segura, V. Calderero, I. Cervera, J. Aparicio, M.V. Jordá, L. Pellín. #ERS Journals Ltd 2004. ABSTRACT: The case of a 55-yr-old male with a right pleural effusion and multiple bilateral nodules is reported. A diagnostic thoracothomy was necessary to obtain a definitive histological diagnosis.During the postoperative course, the subject9s neurological condition deteriorated and multiple cerebral mass lesions were discovered. The pathological analysis of both lung and cerebral tumours revealed an atypical endothelial cell proliferation; vascular immunohistochemical markers, such as factor VIII and CD34, were strongly positive. His general condition remained poor and the patient died 18 months after the initial diagnosis.The final diagnosis was pulmonary epitheloid haemangioendothelioma with synchronous central nervous system dissemination, the first time the authors believe that association has been reported. Little is known of the prognosis and treatment of these tumours, due to their rarity. Negative prognostic factors appear to be the presence of symptoms, pleural effusion or multifocal presentations. Treatment should include surgical resection if possible; chemotherapy appears to have little effect. Watchful waiting is an acceptable option, especially in asymptomatic patients.

show abstract

“…Se ubican principalmente en vasos bronquiales medianos y pequeños. El compromiso bilateral múltiple es la presentación más frecuente (60% de los casos), lo que es compatible con nuestro caso [14][15][16] . El diagnóstico presuntivo de esta entidad se realiza por descarte, y es necesario un alto índice de sospecha luego de descartar los diagnósticos más frecuentes 17 .…”

Section: Discussionunclassified