Intravascular catheter-related bloodstream infection caused by Abiotrophia defectiva in a neutropenic child

Phulpin-Weibel, Aurélie; Gaspar, Nathalie; Emirian, A.; Chachaty, Élisabeth; Valteau-Couanet, D; Gachot, Bertrand

doi:10.1099/jmm.0.047191-0

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…This could be responsible for an increased risk of bacteremia in leukemia patients. Granulicatella and Abiotrophia , formerly known as nutritionally variant streptococcus (NVS), have been commonly implicated in endocarditis and bacteraemia, and also in several other infections such as central nervous system infections, otitis media, cholangitis and arthritis [46], [47]. A high mortality rate for endocarditis by NVS has been reported [48], [49].…”

Section: Discussionmentioning

confidence: 99%

Oral Microbiota Distinguishes Acute Lymphoblastic Leukemia Pediatric Hosts from Healthy Populations

et al. 2014

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In leukemia, oral manifestations indicate aberrations in oral microbiota. Microbiota structure is determined by both host and environmental factors. In human hosts, how health status shapes the composition of oral microbiota is largely unknown. Taking advantage of advances in high-throughput sequencing, we compared the composition of supragingival plaque microbiota of acute lymphoblastic leukemia (ALL) pediatric patients with healthy controls. The oral microbiota of leukemia patients had lower richness and less diversity compared to healthy controls. Microbial samples clustered into two major groups, one of ALL patients and another of healthy children, with different structure and composition. Abundance changes of certain taxa including the Phylum Firmicutes, the Class Bacilli, the Order Lactobacillales, the Family Aerococcaceae and Carnobacteriaceae, as well as the Genus Abiotrophia and Granulicatella were associated with leukemia status. ALL patients demonstrated a structural imbalance of the oral microbiota, characterized by reduced diversity and abundance alterations, possibly involved in systemic infections, indicating the importance of immune status in shaping the structure of oral microbiota.

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