Intravascular Coagulation in Liver Disease

Verstraete, Marc; Vermylen, Jozef; Collen, Désiré

doi:10.1146/annurev.me.25.020174.002311

Cited by 92 publications

(33 citation statements)

References 22 publications

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“…Coagulação intravascular disseminada associada à presença de trombos de fibrina nos sinusóides hepáticos tem sido descrita nas hepatotoxicoses agudas (Verstraete et al 1974). Nos ovinos desse estudo, essa alteração não pôde ser confirmada pois não se observou fibrina polimerizada na luz dos capilares hepáticos e renais.…”

Section: Discussionunclassified

Intoxicação experimental pelos frutos de Xanthium cavanillesii (Asteraceae) em ovinos

et al. 1999

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Os frutos moídos de Xanthium cavanillesii foram administrados por via oral, em doses únicas ou fracionadas, a 15 ovinos adultos. Nove ovinos morreram. Doses a partir de 2 g/kg em uma única administração foram letais para os ovinos. Doses únicas de 1,25 g/kg e doses de 2,5 g/kg subdivididas em duas administrações diárias (1,25 g/kg em dois dias consecutivos) não causaram a intoxicação. Sinais clínicos foram observados apenas nos animais que morreram. Iniciavam entre 5 horas e 20 horas após o início da administração dos frutos. A evolução do quadro clínico foi superaguda (90 minutos a 3 horas) ou aguda (9 a 13 horas). Sinais clínicos incluíam apatia, anorexia, hipomotilidade ruminal, tremores musculares generalizados, incoordenação motora, andar rígido, relutância em caminhar, instabilidade, quedas e decúbito. Muitos animais apresentavam corrimento nasal seromucoso que dificultava a respiração. Nas fases terminais havia tiques, sialorréia, convulsões, nistagmo, movimentos de pedalagem e períodos de apnéia seguidos de morte. Os principais achados de necropsia incluíam acentuação do padrão lobular do fígado acompanhada de petéquias distribuídas aleatoriamente na superfície capsular e de corte, distensão da vesícula biliar associada a edema e hemorragias na parede, ascite, hidrotórax, edema gelatinoso e translúcido da região perirrenal, conteúdo do ceco e alça proximal do cólon ascendente ressequido, compactado, recoberto por muco e estrias de sangue coagulado. Havia petéquias e sufusões disseminadas. A principal lesão microscópica consistia em acentuada necrose coagulativa hepatocelular centrolobular ou massiva acompanhada de congestão e hemorragia e vacuolização ou tumefação dos hepatócitos remanescentes.

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Section: Discussionunclassified

Intoxicação experimental pelos frutos de Xanthium cavanillesii (Asteraceae) em ovinos

et al. 1999

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“…This alteration might be triggered by several factors such as sepsis [42], an increase in intestinal endotoxin pool by aerobic gram negative bacilli [43], the presence of circulat ing clot-promoting endotoxin released by the intestinal bacteria into the portal system [44,45], the release of tissue thromboplastin or a procoagulant from the diseased liver cells [46] or other traumatizing factor(s). Each of these mechanisms might activate the coagulation system and subsequently stimulate fibrinoly sis leading to DIC.…”

Section: Discussionmentioning

confidence: 99%

Disseminated Intravascular Coagulation in Endemic Hepatosplenic Schistosomiasis

Omran

El-Bassiouni²,

Hussein³

et al. 1995

Pathophysiol Haemos Thromb

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Thrombin and plasmin generation were assessed in patients with endemic hepatosplenic schistomiasis (15 hepatospleno-megalic, 15 splenomegalic, 15 with advanced hepatic fibrosis and ascites and 15 hepatosplenic patients with hematemesis). Prolongation of prothrombin time, partial thromboplastin time and thrombin time, thrombocytopenia, hypofibrinogenemia, a decrease in antithrombin III and protein C and S levels and elevation in fibrinopeptide A, D-dimer and thrombin-antithrombin complex levels were detected in all groups. The deficit in hemostatic parameters was more pronounced with the advancement of the disease and was maximal in the hematemesis group. Our data demonstrate an increase in both thrombin and plasmin generation and indicate that low grade disseminated intravascular coagulation may occur in association with endemic Egyptian hepatosplenic schistosomiasis even in the steady state without overt bleeding.

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“…An identical phenomenon is observed in our group of cirrhotics. However, the existence of a low-grade intravascular coagu lation in hepatic cirrhosis has been the subject of controversy [5,33]. The interpretation of the high levels of F VIII activity, RA and von Wille brand factor in hepatic cirrhosis can only be speculative until more infor mation is available about the metabolism of F VIII protein.…”

Section: Discussionmentioning

confidence: 99%

Antihaemophilic Factor A Activity, F VIII-Related Antigen and von Willebrand Factor in Hepatic Cirrhosis

Baele¹,

Matthijs²,

Barbier³

1977

Acta Haematol

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F VIII activity, F VIII-related antigen and von Willebrand factor were measured in 46 patients with hepatic cirrhosis and in 30 normal individuals. These parameters were significantly higher in hepatic cirrhosis than in the controls. Linear relationships between F VIII activity and F VIII-related antigen and between F VIII-related antigen and von Willebrand factor were found in patients with hepatic cirrhosis as well as in normal individuals. However, in both groups no relationship between F VIII activity and von Willebrand factor was present. The existence of a low-grade intravascular coagulation in hepatic cirrhosis may be postulated but more information about the metabolism of F VIII protein is needed before such a statement can be proven.

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Intravascular Coagulation in Liver Disease

Cited by 92 publications

References 22 publications

Intoxicação experimental pelos frutos de Xanthium cavanillesii (Asteraceae) em ovinos

Intoxicação experimental pelos frutos de Xanthium cavanillesii (Asteraceae) em ovinos

Disseminated Intravascular Coagulation in Endemic Hepatosplenic Schistosomiasis

Antihaemophilic Factor A Activity, F VIII-Related Antigen and von Willebrand Factor in Hepatic Cirrhosis

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