Intravascular cytotoxic T-cell lymphoma: A case report and review of the literature

Gleason, Briana C.; Brinster, Nooshin; Granter, Scott R.; Pinkus, Geraldine S.; Lindeman, Neal I.; Miller, Danielle M.

doi:10.1016/j.jaad.2006.12.022

Cited by 35 publications

(29 citation statements)

References 22 publications

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“…26,27 Some authors recommend autologous hematopoietic stem cell transplantation after the first complete remission in young patients with good performance status. 2,28 Our case represents a favorable prognostic form of a disease, IVL, that otherwise is considered an extremely aggressive lymphoma. This case demonstrates the complexity and the different prognostic subtypes of IVL.…”

Section: Discussionmentioning

confidence: 96%

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Intravascular large B-cell lymphoma: Remission after rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy

Hórvath

Demeter

Erős

et al. 2009

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 96%

“…1 Most cases are B-cell origin; T-cell phenotype is extremely rare. 2,3 The prognosis of this high-grade B-cell lymphoma improved since the introduction of anti-CD20 monoclonal antibody, rituximab (R). 4 IVL is characterized by proliferation of malignant lymphoid cells within the lumen of small arteries, veins, and capillaries.…”

Section: Discussionmentioning

confidence: 99%

Intravascular large B-cell lymphoma: Remission after rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy

Hórvath

Demeter

Erős

et al. 2009

Journal of the American Academy of Dermatology

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“…9 Although most cases of IVL have a B-cell phenotype, exceedingly rare cases with a NK/T-cell phenotype have been described. 10 Both the B-cell and the NK/T-cell types of IVL are characterized by the presence of dilated capillaries stuffed with atypical lymphoid cells. The extravascular spaces are practically devoid of any infiltrate.…”

Section: Discussionmentioning

confidence: 99%

Intralymphatic Proliferation of T-cell Lymphoid Blasts in the Setting of Hidradenitis Suppurativa

Calamaro

Cerroni

2016

The American Journal of Dermatopathology

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Intralymphatic proliferation of T-cell lymphoid blasts (IPTCLBs) is a rare, recently described entity, associated with cutaneous inflammatory conditions and characterized by intralymphatic proliferation of highly proliferating, blastoid T lymphocytes expressing CD30, thus mimicking an intravascular lymphoma. In all reported cases, the intralymphatic proliferation was associated with an underlying inflammatory condition, with no clonal T-cell receptor rearrangement, no signs of systemic or cutaneous lymphoma, and excellent prognosis. The authors present a new case of IPTCLB arising in a patient with hidradenitis suppurativa. Histological examination revealed a dilated follicle embedded within a fibrotic stroma surrounded by a dense lymphoid infiltrate characterized by the presence of dilated small vessels filled with atypical medium-to-large sized blastoid lymphocytes expressing a CD4 T phenotype. There was also expression of CD30, but negativity for cytotoxic markers and Epstein-Barr virus. The proliferation index was high and the vessels showed expression of D2-40, confirming their lymphatic nature. No signs of systemic lymphoma could be detected after routine investigations, and the patient is alive and in good general health. IPTCLB is a rare benign entity that presents with worrying, potentially misleading histopathological features that mimic those observed in intravascular lymphoma. Careful histological and phenotypic investigations and correlation with the clinical features are necessary for a proper diagnosis.

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“…The majority of reported cases of IVL are large B-cell lymphomas (2), and only a few cases of lymphoma of T-cell lineage and histiocytic malignancies have been described (3)(4)(5)(6). To the best of our knowledge, only six cases of IVL with a definite NK-cell phenotype have been reported in English literature (1,(7)(8)(9)(10).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Intravascular Natural Killer-cell Lymphoma: A Rare Case and Review of the Literature

Liao¹,

Hsieh²,

Hwang³

et al. 2011

Acta Derm Venerol

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Intravascular lymphoma (IVL) is a rare and aggressive variant of extranodal non-Hodgkin's lymphoma, characterized by almost exclusive proliferation of neoplastic lymphocytes within the blood vessel lumen, and a predilection for the skin and brain ( 1 ). Cases of IVL of T-cell or natural killer (NK)-cell lineage are even rarer. We report here a case of cutaneous intravascular NK-cell lymphoma (IVNKL) presenting with multiple erythematous, indurated, tender plaques over both the lower extremities. CASE REPORTA 42-year-old Taiwanese woman visited our dermatology clinic with complaints of increasing numbers of erythematous, indurated, tender plaques over both the lower extremities, especially the thighs, for 7 months (Fig. 1 ). Constitutional symptoms, such as malaise, dizziness, and chilly sensations, were also noted. Under the preliminary impression of panniculitis, a biopsy of the skin of the left thigh was performed. A histological study revealed many distended vessels filled with atypical large lymphoid cells in the dermis and subcutis (Fig. 2A). The tumour cells were all confined within the vessels and had large, irregular hyperchromatic nuclei with ample eosinophilic cytoplasm (Fig. 2B). Scattered mitotic figures were found. Fibrin thrombi mixed Fig. I. A 42-year-old Taiwanese woman with increasing number of erythematous indurated tender plaques over both the lower extremities for 7 months.with atypical lymphoid cells were occasionally found. The vessels were surrounded by a small number of non-neoplastic lymphocytes. Immunohistochemical studies showed that the tumour cells were CD3s% CD56% granzyme B*, ßFl , CD4 , CD5 , CD8% CD20 , CD30 , Pax5 , and TdT . Approximately 99% of the tumour cells were Ki-67-positive. In situ hybridization for Epstein-Barr virus-encoded RNA (EBER) revealed the presence of the Epstein-Barr virus (EBV) (Fig. SI, available at

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Intravascular cytotoxic T-cell lymphoma: A case report and review of the literature

Cited by 35 publications

References 22 publications

Intravascular large B-cell lymphoma: Remission after rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy

Intravascular large B-cell lymphoma: Remission after rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy

Intralymphatic Proliferation of T-cell Lymphoid Blasts in the Setting of Hidradenitis Suppurativa

Cutaneous Intravascular Natural Killer-cell Lymphoma: A Rare Case and Review of the Literature

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