Intravascular large b-cell lymphoma diagnosed at autopsy: A case report

Ricciardo, Sean; Kumar, Beena

doi:10.1016/j.pathol.2015.12.217

Cited by 1 publication

(4 citation statements)

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“…The neoplastic cells are large, with pleomorphic and hyperchromatic nuclei, one to multiple visible nucleoli, and scant cytoplasm. Frequent mitoses are common, and there is a tendency for an increased proliferation index 9–11 . Classically, IVLBCL is rarely found in the peripheral blood, lymph nodes, cerebrospinal fluid, and bone marrow until late in the disease course 7 .…”

Section: Discussionmentioning

confidence: 99%

“…Considered a “great imitator “by oncologists, the differential diagnosis is broad and largely dependent upon which organ systems are affected 1,7,9 . Given the common presentation of fever with nonspecific symptoms, if a decedent makes it to the hospital, rheumatologic or infectious etiologies are often initially considered 1,10,12 . Neurologic symptoms in IVLBCL can mimic a multitude of diseases including stroke, Guillain-Barré syndrome, encephalomyelitis, vasculitis, polymyalgia rheumatica, temporal arteritis, and multiple sclerosis 11,12,14 .…”

Section: Discussionmentioning

confidence: 99%

“…Frequent mitoses are common, and there is a tendency for an increased proliferation index. [9][10][11] Classically, IVLBCL is rarely found in the peripheral blood, lymph nodes, cerebrospinal fluid, and bone marrow until late in the disease course. 7 Additional microscopic findings include hemorrhage, fibrin thrombi, and necrosis.…”

Section: Discussionmentioning

confidence: 99%

“…1,7,9 Given the common presentation of fever with nonspecific symptoms, if a decedent makes it to the hospital, rheumatologic or infectious etiologies are often initially considered. 1,10,12 Neurologic symptoms in IVLBCL can mimic a multitude of diseases including stroke, Guillain-Barré syndrome, encephalomyelitis, vasculitis, polymyalgia rheumatica, temporal arteritis, and multiple sclerosis. 11,12,14 Diagnostic considerations for possible cutaneous manifestations of IVLBCL include cellulitis, panniculitis, erythema nodosum, vasculitis, Kaposi sarcoma, angiosarcoma, mycosis fungoides, reactive angioendotheliomatosis, intravascular histiocytosis, and skin cancer.…”

Section: Discussionmentioning

confidence: 99%

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Intravascular Large B-cell Lymphoma Presenting as Sudden Death

Jackson¹

2023

Am J Forensic Med Pathol

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Intravascular large B-cell lymphoma is a rare subset of non-Hodgkin lymphoma composed of mature B lymphoma cells confined to the intravascular space. This disease remains elusive because it lacks a discrete tumor mass, can affect any part of the body, and has vague symptoms paired with heterogeneous clinical findings resulting in delayed or missed accurate diagnosis, even at postmortem examination. This is a case of a woman who died within hours of presenting to the emergency department with a diagnosis of intravascular large B-cell lymphoma made through autopsy examination, adding to the knowledge of this rare disease and bringing it to the attention of practicing autopsy and forensic pathologists.

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Section: Discussionmentioning

confidence: 99%