Intravascular lymphomatosis

Oei, Melina E.; Kraft, George H.; Sarnat, Harvey B.

doi:10.1002/mus.10091

Cited by 24 publications

(14 citation statements)

References 9 publications

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“…She Table 1). The central nervous system is affected in almost two-thirds of cases in Western patients with IVL [1][2][3]5]. As represented by patients 2 and 3, signs caused by obliteration of vessels can remit spontaneously or to steroid treatment, which could erroneously be related to other diseases (Table 1) [4,[7][8][9][10].…”

Section: Patientmentioning

confidence: 98%

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Intravascular lymphomatosis of the nervous system

et al. 2008

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Section: Patientmentioning

confidence: 98%

“…Its rarity (one person per million), multiplicity of presentations, and absence of lymphoma cells in the reticuloendothelial system complicate early diagnosis [2][3][4][5]. Most of IVL belong to systemic diffuse large B cell lymphomas (DLBCL), but aberrant expression of integrins prohibits extravasal migration [6].…”

mentioning

confidence: 99%

Intravascular lymphomatosis of the nervous system

et al. 2008

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“…Diagnosis is typically by biopsy of the skin or brain or bone marrow(5, 6) or other lesion in certain variant cases (7,8) including the adrenal grands (9), although occasional worsening has been described after brain or spinal cord biopsy (10). Skin lesions of IVL include teleangiectasias, hemorrhagic nodules and leg lymphedema(3).…”

Section: Skin Biopsymentioning

confidence: 99%

“…Such poor prognosis reflects in part delays in diagnosis. Amongthese therapies, patients treated by a combination of chemotherapy were reported to have long-term survival and to be alive in complete remission (4,(6)(7)(8)(9)(10)13). It is the most favorable therapy at present.…”

Section: Skin Biopsymentioning

confidence: 99%

Intravascular Large B Cell Lymphoma Diagnosed by Senile Angioma Biopsy.

et al. 2003

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An 82-year-old man without notable medical history was admitted to our hospital following subacute deterioration of apettite, disorientation and strange behavior. There was spasticity of the right extremities without weakness. LDHand serum soluble IL2 receptor antibody levels were elevated, and as well as the protein level and IgG levels in the cerebrospinal fluid. CT scanning of the brain revealed a lesion at the left corona radiata. The patient's level of consciousness was worsening, and follow-up study of the brain showed a new lesion in the left occipital lobe. Intravascular lymphomatosis was therefore suspected. Weperformed a skin biopsy from two typical senile angiomas. In one of these biopsy specimens, a capillary hemangiomawas present in the midreticular dermis and it was filled with abnormal B cells.The diagnosis of intravascular B cell lymphoma (IVL) was thus established. IVL is a rare subtype of extranodal diffuse large B cell lymphoma with a poor outcome.However, it is recently thought that if the diagnosis is established early, aggressive chemotherapy increases survival. Senile angioma is a skin eruption that is considered prevalent for the most part in elderly people. If a patient is suspected to have IVL, and there is no appropriate site of biopsy, it might be beneficial to try a skin biopsy aiming at senile angiomas for early diagnosis. (Internal Medicine 42: 117-120, 2003)

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“…IVL is a systemic condition that commonly affects the nervous system, presenting as multifocal cerebrovascular events, paraparesis, encephalopathy, and peripheral neuropathies due to occlusion of blood vessels [11] and direct neuronal infiltration [12]. Cutaneous involvement is also common [13].…”

Section: Introductionmentioning

confidence: 99%

Intravascular T-cell lymphoma with bowel involvement: Case report and literature review

et al. 2005

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Intravascular lymphoma (IVL) is a rare form of non-Hodgkin lymphoma characterized by massive proliferation of large, neoplastic cells in small-and medium-sized blood vessels. Most cases of IVL are of B-cell immunophenotype; fewer than 15 cases of T-cell IVL have been reported. A 23-year-old male presented with acute abdominal pain, fever, and tender lower abdomen. Pathology at laparotomy revealed infiltration of colonic vessels with large lymphoid cells compatible with IVL. We reviewed all cases of IVL diagnosed at the Queen Elizabeth II Health Sciences Centre in Halifax, Nova Scotia, from August 1992 to August 2002. A literature review was also performed. Five additional cases of IVL were identified at this institution during a 10-year period. Three patients presented with neurological symptoms, and two with abdominal pain. In 4 of 5 cases, patients died of lymphoma within 3 months of presentation; one patient experienced a 10-month remission. While visceral involvement with IVL is common at autopsy, IVL presenting as an acute abdomen in an immunocompetent patient has not previously been described. Among the 15 cases of T-cell IVL reported in the literature, only two occurred in people under age 30. Given the rarity of T-cell IVL, it is remarkable that three cases of T-cell IVL have been diagnosed at our institution during a 10-year period. Am.

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Intravascular lymphomatosis

Cited by 24 publications

References 9 publications

Intravascular lymphomatosis of the nervous system

Intravascular lymphomatosis of the nervous system

Intravascular Large B Cell Lymphoma Diagnosed by Senile Angioma Biopsy.

Intravascular T-cell lymphoma with bowel involvement: Case report and literature review

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