2013
DOI: 10.1117/1.jbo.18.5.056009
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Intravascular near-infrared fluorescence catheter with ultrasound guidance and blood attenuation correction

Abstract: Abstract. Intravascular near-infrared fluorescence (NIRF) imaging offers a new approach for characterizing atherosclerotic plaque, but random catheter positioning within the vessel lumen results in variable light attenuation and can yield inaccurate measurements. We hypothesized that NIRF measurements could be corrected for variable light attenuation through blood by tracking the location of the NIRF catheter with intravascular ultrasound (IVUS). In this study, a combined NIRF-IVUS catheter was designed to acq… Show more

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Cited by 21 publications
(26 citation statements)
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References 58 publications
(68 reference statements)
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“…Previous multimodal catheters reported frame rates of less than 10 images/second in fluorescence imaging with a larger catheter than us [22]- [24]. Our scanning system and catheter allowed colocalized acquisitions of fluorescence and ultrasound at a frame rate of 30 images/second.…”
Section: Discussionmentioning
confidence: 90%
See 1 more Smart Citation
“…Previous multimodal catheters reported frame rates of less than 10 images/second in fluorescence imaging with a larger catheter than us [22]- [24]. Our scanning system and catheter allowed colocalized acquisitions of fluorescence and ultrasound at a frame rate of 30 images/second.…”
Section: Discussionmentioning
confidence: 90%
“…Images were aligned with IVUS acquired with a different catheter, which complicated experimental acquisitions. Catheters combining IVUS and fluorescence imaging were also designed, but they remain relatively large in size [22]- [24].…”
mentioning
confidence: 99%
“…For that reason there is a need to correct the acquired NIRS data before any assessment can be made [35]. This issue is also present in the case of the NIRF imaging, where attempts to correct for the distance dependence have been reported by various researchers [22], [36]. …”
Section: Resultsmentioning
confidence: 99%
“…Multimodal intravascular imaging catheters, which perform the co-registration at hardware level, have been developed for other applications, i.e., NIRF/IVUS [36] Such hardware adaptation is essential as the combined cardiac and breathing motion will make the guide-wire based co-registration impractical. This will only require a minor modification to the proposed co-registration methodology: the detection of an image feature will be replaced with a predefined angular delay between the two modalities, and the co-registration process will proceed as described in this paper.…”
Section: Discussionmentioning
confidence: 99%
“…Conventional grayscale IVUS is, however, limited with regards to the analysis of plaque composition [9], whereas emerging molecular imaging technologies, such as fluorescence imaging, have been developed to overcome these limitations. Multimodality imaging systems, such as the dual-modality IVUS/near-infrared fluorescence (NIRF) imaging catheter previously engineered by our group and others [10,11,12,13], were designed for integrated microstructural and molecular plaque imaging, thus enabling a more detailed plaque characterization. The use of molecular probes in conjunction with fluorescence imaging has been shown to provide complementary information with regards to plaque activity and inflammation [14,15,16,17,18,19].…”
Section: Introductionmentioning
confidence: 99%