Intravascular papillary endothelial hyperplasia (Masson's tumour) of the oral mucosa

Murugaraj, V.; Kingston, G T; Patel, Mallika; Anand, Raja

doi:10.1016/j.bjoms.2009.12.009

Cited by 20 publications

(18 citation statements)

References 5 publications

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“…Clinically, the lesion has been mistaken for and should be differentiated from mucocele, hemangioma, lymphangioma, angiosarcoma, hematoma, Kaposi sarcoma, hemangioendothelioma, thrombosed vein, phlebectasia, traumatic fibroma, melanoma, fibroepithelial polyp, nonodontogenic soft tissue infection, intramassetric abscess, cysticercosis, benign neoplasms of smooth muscle origin, and reactive and neoplastic neural lesions like traumatic neuroma, neurofibroma, and neurilemmoma [7, 10, 11]. …”

Section: Discussionmentioning

confidence: 99%

Intravascular Papillary Endothelial Hyperplasia: Diagnostic Sequence and Literature Review of an Orofacial Lesion

Guledgud

Patil

Degala

et al. 2014

Case Reports in Dentistry

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Intravascular papillary endothelial hyperplasia or Masson's tumor is a rare reactive disease of vascular origin characterized by exuberant proliferation of endothelial cells notably occurring within blood vessels of head, neck, and extremities. The importance of this entity is its ability to mimic a variety of diseases both benign and malignant in the orofacial region. Here, we present a case of Masson's tumor within the masseter muscle in a 40-year-old female with emphasis on the sequential investigative procedures performed to diagnose this entity.

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Section: Discussionmentioning

confidence: 99%

Intravascular Papillary Endothelial Hyperplasia: Diagnostic Sequence and Literature Review of an Orofacial Lesion

Guledgud

Patil

Degala

et al. 2014

Case Reports in Dentistry

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“…The majority of the described cases in the head and neck were reported in the oral mucosa, lower and upper lips, tongue, gingiva, skin, subcutaneous tissue of the face and scalp, intracranium, orbit and ocular adnexa. Clinically, IPEH may simulate mucocele, hemangioma, lymphangioma, angiosarcoma, hematoma, Kaposi's sarcoma, hemangioendothelioma, thrombosed vein, phlebectasia, traumatic fibroma, melanoma, fibroepithelial polyp, non-odontogenic soft tissue infection, intramasseteric abscess, cysticercosis, benign neoplasms of smooth muscle origin, and reactive and neoplastic neural lesions, such as traumatic neuroma, neurofibroma and neurilemmoma (8)(9)(10). Radiologically, no specific findings have been found to be characteristic of IPEH.…”

Section: Introductionmentioning

confidence: 99%

Extravascular type of intravascular papillary endothelial hyperplasia mimicking parotid gland neoplasia and the possible role of ferritin in the pathogenesis: A case report

Mignogna

Barca

Vito

et al. 2016

Molecular and Clinical Oncology

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Abstract. Intravascular papillary endothelial hyperplasia (IPEH) is defined as a vascular lesion characterized by extensive proliferation of vascular endothelial cells. This lesion was first described by Pierre Masson in 1923 as intravascular hemangioendothelioma. The most frequent sites of involvement are the skin and subcutis. IPEH comprises ~2% of the vascular tumors of the skin and subcutaneous tissue and it has a predilection for the head, neck, trunk and the extremities. The diagnosis is based on histopathology. We herein present the second case of Masson's tumor of the parotid gland described in literature. The patient was a 70-year-old female. Magnetic resonance imaging revealed an irregular lesion with smooth margins, initially considered to be compatible with pleomorphic adenoma. Immunohistochemical analysis revealed positivity of the tumor cells for ferritin heavy and light chains, vimentin and CD31. The aim of the present study was to emphasize the immunohistochemical characteristics and briefly discuss the potential role of ferritin in the pathogenesis of IPEH.

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“…Females are slightly more affected than males (ratio 1.14 : 1) and the oral site most frequently involved is the lower lip (40.5%), although nearly any other oral site can be affected [6]. IPEH usually manifests as a soft to firm painless mass, sometimes tender, ranging in size from 0.5 to 1.8 cm in diameter and imparts a reddish blue color to the overlying skin or mucous membrane [6–8]. An interesting finding in the current case was the presence of high-caliber varices in feet and legs that might demonstrate association with other vascular malformations.…”

Section: Discussionmentioning

confidence: 99%

“…Most importantly, IPEH lacks cellular atypia, atypical mitosis, and an infiltrative pattern of growth; all these important features are often indicative of malignancy. In fact, low-grade angiosarcoma presents infiltrative growth pattern, as well as nuclear hyperchromatism, mitosis, cellular atypia, and necrosis [3, 8]. Three different types of IPEH have been reported: (a) a primary (pure) form where changes are observed in a distended vessel; (b) a secondary (mixed) form that occurs in preexisting varices, hemangiomas, pyogenic granulomas, or lymphangiomas; and (c) an uncommon type in an extravascular location [11].…”

Section: Discussionmentioning

confidence: 99%

Oral Intravascular Papillary Endothelial Hyperplasia Associated with an Organizing Thrombus: Case Report and Immunohistochemical Analysis

Fernandes

Travassos

Ferrisse

et al. 2016

Case Reports in Pathology

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Intravascular papillary endothelial hyperplasia (IPEH) is a benign lesion of the skin and mucosa of vascular origin characterized by reactive proliferation of endothelial cells. A 76-year-old woman was referred presenting a painless nodule on the lip. Intraoral examination revealed bluish submucosal nodular proliferation, measuring 10 × 5 × 5 mm, affecting the lower labial mucosa. The lesion had a firm consistency and it was not fixed to the adjacent tissues. The main differential diagnoses were mucocele/mucus retention cyst, sialolith, or salivary gland neoplasia. An incisional biopsy was performed and during the intraoperative procedure an encapsulated red-bluish nodular mass was observed. Microscopic analysis revealed papillary endothelial proliferation in the center of the lesion and fibrin admixed with inflammatory cells in organization peripherally. There was no nuclear atypia, mitotic figures, or necrosis. The endothelial cells were CD34 positive, with low Ki-67 proliferation index (4%). α-SMA highlighted the vessel walls, whereas negativity for D2-40 excluded lymphatic origin. Final diagnosis was IPEH associated with an organizing thrombus. Dentists should be aware about this rare benign vascular lesion, whose final diagnosis is achieved only after histopathology analysis. Surgical removal is the treatment of choice and no recurrence is expected.

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Intravascular papillary endothelial hyperplasia (Masson's tumour) of the oral mucosa

Cited by 20 publications

References 5 publications

Intravascular Papillary Endothelial Hyperplasia: Diagnostic Sequence and Literature Review of an Orofacial Lesion

Intravascular Papillary Endothelial Hyperplasia: Diagnostic Sequence and Literature Review of an Orofacial Lesion

Extravascular type of intravascular papillary endothelial hyperplasia mimicking parotid gland neoplasia and the possible role of ferritin in the pathogenesis: A case report

Oral Intravascular Papillary Endothelial Hyperplasia Associated with an Organizing Thrombus: Case Report and Immunohistochemical Analysis

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