Intravenous Acetaminophen—Progress in Relief of Pain?

O’Malley, Patricia Anne

doi:10.1097/nur.0b013e31829753d8

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…2 However, the emergence of intravenous formulations of paracetamol in 2002 as part of multimodal analgesia provided an additional route of administration for caregivers. This review explored the effectiveness of intravenous paracetamol or intravenous propacetamol (a prodrug form of paracetamol) for postoperative care, updating an earlier review from 2011.…”

Section: Contextmentioning

confidence: 99%

“…To limit injury, it is important to ensure safe passage from intravenous administration to oral dosing and patient education to reduce the risk of combining multiple paracetamol-based products. 2 The findings of this review are supplemented by emerging research examining the outcomes of therapy by the type of pain and intravenous versus oral dosing. In a recent retrospective analysis, outcomes were examined for 112 586 adult spine surgery patients, of which 51 835 received intravenous paracetamol with no exclusions based on additional pain management.…”

Section: Commentarymentioning

confidence: 99%

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Intravenous paracetamol or intravenous propacetamol can provide effective postoperative analgesia for some patients

O’Malley

2017

Evid Based Nurs

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Section: Contextmentioning

confidence: 99%

Section: Commentarymentioning

confidence: 99%

Intravenous paracetamol or intravenous propacetamol can provide effective postoperative analgesia for some patients

O’Malley

2017

Evid Based Nurs

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Intravenous Paracetamol vs Intranasal Desmopressin for Renal Colic in the Emergency Department: A Randomized Clinical Trial

et al. 2020

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Objective To evaluate the analgesic efficacy of intranasal desmopressin alone vs intravenous paracetamol in patients referred to the emergency department with renal colic. Design Randomized clinical trial. Setting This study was conducted in the emergency unit of a university hospital. Subjects Patients referred to the emergency room with renal colic. Primary Outcome Effect of intranasal desmopressin in pain relief in comparison with intravenous paracetamol. Methods In this trial, 240 patients diagnosed with renal colic were randomly divided into two groups to compare the analgesic effect of intravenous paracetamol (15 mg/kg) and intranasal desmopressin spray (40 μg). Pain scores were measured by a numeric rating scale at baseline and after 15, 30, and 60 minutes. Adverse effects and need for rescue analgesic (0.05 mg/kg max 3 mg morphine sulphate) were also recorded at the end of the study. Results Three hundred patients were eligible for the study; however, 240 were included in the final analysis. The patients in the two groups were similar in their baseline characteristics and baseline pain scores. The mean pain score after 15 minutes was more reduced and was clinically significant (>3) in the desmopressin group (P < 0.0001). There was no significant difference between mean pain scores in the two groups after 30 minutes (P = 0.350) or 60 minutes (P = 0.269), but the efficacy of the two drugs was significant in terms of pain reduction (>6). Conclusions Our study showed that intranasal desmopressin is as effective as intravenous paracetamol for renal colic pain management; however, significant clinical reduction in pain score occurred faster with intranasal desmopressin.

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Safety of Postoperative Opioid Alternatives in Plastic Surgery: A Systematic Review

O’Neill

Hayes

Davison

2019

Plastic &Amp; Reconstructive Surgery

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Summary: With the growing opioid epidemic, plastic surgeons are being encouraged to transition away from reliance on postoperative opioids. However, many plastic surgeons hesitate to use nonopioid analgesics such as nonsteroidal antiinflammatory drugs and local anesthetic blocks because of concerns about their safety, particularly bleeding. The goal of this systematic review is to assess the validity of risks associated with nonopioid analgesic alternatives. A comprehensive literature search of the PubMed and MEDLINE databases was conducted regarding the safety of opioid alternatives in plastic surgery. Inclusion and exclusion criteria yielded 34 relevant articles. A systematic review was performed because of the variation between study indications, interventions, and complications. Thirty-four articles were reviewed that analyzed the safety of ibuprofen, ketorolac, celecoxib, intravenous acetaminophen, ketamine, gabapentin, liposomal bupivacaine, and local and continuous nerve blocks after plastic surgery procedures. There were no articles that showed statistically significant bleeding associated with ibuprofen, celecoxib, or ketorolac. Similarly, acetaminophen administered intravenously, ketamine, gabapentin, and liposomal bupivacaine did not have any significant increased risk of adverse events. Nerve and infusion blocks have a low risk of pneumothorax. Limitations of this study include small sample sizes, different dosing and control groups, and more than one medication being studied. Larger studies of nonopioid analgesics would therefore be valuable and may strengthen the conclusions of this review. As a preliminary investigation, this review showed that several opioid alternatives have a potential role in postoperative analgesia. Plastic surgeons have the responsibility to lead the reduction of postoperative opioid use by further developing multimodal analgesia.

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Intravenous Acetaminophen—Progress in Relief of Pain?

Cited by 3 publications

References 11 publications

Intravenous paracetamol or intravenous propacetamol can provide effective postoperative analgesia for some patients

Intravenous paracetamol or intravenous propacetamol can provide effective postoperative analgesia for some patients

Intravenous Paracetamol vs Intranasal Desmopressin for Renal Colic in the Emergency Department: A Randomized Clinical Trial

Safety of Postoperative Opioid Alternatives in Plastic Surgery: A Systematic Review

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