2003
DOI: 10.1089/152581603322022990
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Intravenous Administration of Human Umbilical Cord Blood Cells in a Mouse Model of Amyotrophic Lateral Sclerosis: Distribution, Migration, and Differentiation

Abstract: Amyotrophic lateral sclerosis (ALS), a multifactorial disease characterized by diffuse motor neuron degeneration, has proven to be a difficult target for stem cell therapy. The primary aim of this study was to determine the long-term effects of intravenous mononuclear human umbilical cord blood cells on disease progression in a well-defined mouse model of ALS. In addition, we rigorously examined the distribution of transplanted cells inside and outside the central nervous system (CNS), migration of transplante… Show more

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Cited by 268 publications
(164 citation statements)
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“…(e) Tail suspension test-The mouse was suspended by its tail and extension of hindlimbs observed (Garbuzova-Davis et al, 2003). The deficits scores are: grade 0, normal; grade 1, partial hindlimb extension; grade 2, no hindlimb extension.…”
Section: (D) Screen Test-this Test Serves As An Indicator Of General mentioning
confidence: 99%
“…(e) Tail suspension test-The mouse was suspended by its tail and extension of hindlimbs observed (Garbuzova-Davis et al, 2003). The deficits scores are: grade 0, normal; grade 1, partial hindlimb extension; grade 2, no hindlimb extension.…”
Section: (D) Screen Test-this Test Serves As An Indicator Of General mentioning
confidence: 99%
“…In animal models with a neuroinflammatory component such as stroke, traumatic brain injury, spinal cord injury, and multiple sclerosis, therapeutic somatic stem cells (for example, BMSCs, umbilical cord blood stem cells, MSCs, and NPCs) target inflamed CNS areas where they persist for months and promote recovery through neuroprotective mechanisms. 17,27,56,90,98 It is thought that the process of transendothelial migration of somatic stem cells may be regulated in a manner similar to that of inflammatory cells. As early as 30 minutes after stroke, the infiltration of leukocytes, both polymorphonuclear leukocytes and monocytes/macrophages, can be observed.…”
Section: Early Intravascular Cell Deliverymentioning
confidence: 99%
“…Neuroprotection probably occurs through the regulation of the immune system and the inflammatory response [30]. Later, several groups reproduced these findings, describing also paracrine mechanisms of immunomodulation occurring through secretomes, substances that are released when mononuclear cells die [31][32][33]. This change of paradigm is modifying our understanding of regenerative therapies for neurological disease.…”
Section: Stem Cell Therapy and Alsmentioning
confidence: 99%
“…Previous publications described a neuroprotective and neuro regenerative effect of BM-MNCs in CNS [28][29][30] probably due to growth factors that regulate the immune system [31][32][33]. Besides, these BM-MNCs that include mesenchymal (MSCs) and hematopoietic stem cells (HSCs) have been specifically described in ALS models to regenerate motoneurons [41][42][43][44], replace astrocytes contributing to slow motoneuron loss [45], regenerate microglia [46,47] and secrete growth factors promoting maintenance of healthy motoneurons [48,449].…”
Section: Rationalementioning
confidence: 99%