Intravenous aminophylline for acute severe asthma in children over 2 years using inhaled bronchodilators

Mitra, Andrew; Bassler, Dirk; Ducharme, FM

doi:10.1002/14651858.cd001276

Cited by 10 publications

(7 citation statements)

References 18 publications

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“…The Cochrane meta-analysis concludes that addition of methylxanthines to asthma care for status asthmaticus improves asthma symptoms within the first 24 hours; however, use is limited by adverse effects such as nausea and vomiting. 24 One large randomized study of children with severe asthma showed that the addition of methylxanthines significantly decreased the risk of mechanical ventilation. 25 However, no large studies have shown whether systemic b-agonists or methylxanthines are more effective as an additional therapy for severe asthma.…”

Section: Discussionmentioning

confidence: 99%

Regional Variation in ICU Care for Pediatric Patients with Asthma

Bratton

Odetola

McCollegan

et al. 2005

The Journal of Pediatrics

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Section: Discussionmentioning

confidence: 99%

Regional Variation in ICU Care for Pediatric Patients with Asthma

Bratton

Odetola

McCollegan

et al. 2005

The Journal of Pediatrics

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“…Toxicity includes nausea and vomiting, tachycardia, and agitation. Severe and life-threatening toxicity has been reported in the form of cardiac arrhythmias, hypotension, seizures, and death with high theophylline serum concentrations [20,21].…”

Section: Methylxanthines: Aminophyllinementioning

confidence: 99%

Acute Bronchial Asthma

et al. 2011

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Acute asthma is the third commonest cause of pediatric emergency visits at PGIMER. Typically, it presents with acute onset respiratory distress and wheeze in a patient with past or family history of similar episodes. The severity of the acute episode of asthma is judged clinically and categorized as mild, moderate and severe. The initial therapy consists of oxygen, inhaled beta-2 agonists (salbutamol or terbutaline), inhaled budesonide (three doses over 1 h, at 20 min interval) in all and ipratropium bromide and systemic steroids (hydrocortisone or methylprednisolone) in acute severe asthma. Other causes of acute onset wheeze and breathing difficulty such as pneumonia, foreign body, cardiac failure etc. should be ruled out with help of chest radiography and appropriate laboratory investigations in first time wheezers and those not responding to 1 h of inhaled therapy. In case of inadequate response or worsening, intravenous infusion of magnesium sulphate, terbutaline or aminophylline may be used. Magnesium sulphate is the safest and most effective alternative among these. Severe cases may need ICU care and rarely, ventilatory support.

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“…Intravenous aminophylline can be used as an add-on therapy for children with severe asthma exacerbation. [69][70][71] Adverse effects of aminophylline need to be monitored closely in addition to its serum levels. Guidelines recommend the use of aminophylline only in severe patients without response to β2-agonists and steroids in ICU, who can be closely monitored.…”

Section: Aminophyllinementioning

confidence: 99%