Intravenous Carbamazepine for Adults With Seizures

Vickery, P. Brittany; Tillery, Erika E.; DeFalco, Alicia P.

doi:10.1177/1060028017736785

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…It is known that carbamazepine, a potent anticonvulsant used to treat partial and tonic-clonic seizures, can induce granuloma formation and cholestatic and hepatocellular damage in the liver [11][12][13][14][15][16][17][18][19]. In addition, the FDA approved the AMPA antagonist antiepileptic drug perampanel in 2012 [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Even though it undergoes hepatic biotransformation, few studies assess its hepatotoxicity [21].…”

Section: Resultsmentioning

confidence: 99%

“…The tricyclic compound carbamazepine (C 15 H 12 N 2 O) is an antiepileptic drug from the first generation. Not only has it been shown to be beneficial in treating partial and generalized tonic-clonic seizures, but it has also been shown to be effective in treating neuropathic pain and bipolar illness [6,7]. Perampanel is a new-generation antiepileptic drug, a noncompetitive, selective AMPA-receptor antagonist.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of in vitro hepatotoxicity of perampanel in comparison with carbamazepine: old versus new

Farmanlı,

Ilgın,

Ergun

et al. 2023

Eur J Life Sci

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Since the liver metabolizes many drugs, including antiepileptics, this organ is the main target of drug-induced damage. There is very little data on hepatotoxicity due to carbamazepine and perampanel metabolized in the liver. The available data are based solely on published case reports. For this reason, this study aims to evaluate the hepatotoxicity of carbamazepine and perampanel, which are frequently used in treating epilepsy and which do not have a detailed investigation, although they are suspected of hepatotoxicity. Hepatotoxicity in the HepG2 cell line, IC50 values were calculated by MTT cytotoxicity test, followed by determination of apoptosis/necrosis, various biochemical analyzes (ALT, AST, urea), which is currently a biomarker for liver injury, and hepatotoxicity by ROS and GSH determination. Both drugs increased liver biomarkers, oxidative stress, and cytotoxicity in HepG2 cells. The investigation found that the drugs triggered liver apoptosis, not necrosis. In conclusion, Perampanel may have hepatotoxicity similar to carbamazepine.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of in vitro hepatotoxicity of perampanel in comparison with carbamazepine: old versus new

Farmanlı,

Ilgın,

Ergun

et al. 2023

Eur J Life Sci

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“…Carbamazepine is a broad-spectrum antiepileptic drug, that could block sodium channels, voltage-dependent calcium channels, and potassium channels at treatment concentration. There was no correlation between carbamazepine and PLC, so carbamazepine was selected as the negative control for screening [26,27]. The screening results are shown in Figure 3A.…”

Section: Negative Control Test and Positive Control Testmentioning

confidence: 99%

Screening and separation of natural anticancer active ingredients related to phospholipase C

Liu,

Yue,

et al. 2024

J of Separation Science

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Based on the specific binding of drug molecules to cell membrane receptors, a screening and separation method for active compounds of natural products was established by combining phospholipase C (PLC) sensitized hollow fiber microscreening by a solvent seal with high‐performance liquid chromatography technology. In the process, the factors affecting the screening were optimized. Under the optimal screening conditions, we screened honokiol (HK), magnolol (MG), negative control drug carbamazepine, and positive control drug amentoflavone, the repeatability of the method was tested. The PLC activity was determined before and after the screening. Experimental results showed that the sensitization factors of PLC of HK and MG were 61.0 and 48.5, respectively, and amentoflavone was 15.0, carbamazepine could not bind to PLC. Moreover, the molecular docking results were consistent with this measurement, indicating that HK and MG could be combined with PLC, and they were potential interacting components with PLC. This method used organic solvent to seal the PLC greatly ensuring the activity, so this method had the advantage of integrating separation, and purification with screening, it not only exhibited good reproducibility and high sensitivity but was also suitable for screening the active components in natural products by various targets in vitro.

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