Intravenous chlorpromazine in the acute treatment of episodic tension-type headache: a randomized, placebo controlled, double-blind study

Bigal, Marcelo E.; Bordini, Carlos Alberto; Speciali, José Geraldo

doi:10.1590/s0004-282x2002000400004

Cited by 18 publications

(24 citation statements)

References 15 publications

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“…GTBA en sık rastlanan baş ağrısı tipidir ve hayat boyu prevalansı %8 olarak bildirilmiştir (13). Çalışmamızda GTBA, diğer tip baş ağrılarına göre daha sıktı.…”

Section: Discussionunclassified

“…Klorpromazinin epizodik GTBA'da etkinliğinin yüksek olduğunu bildirilmiştir. Bu çalışma dopaminin baş ağrısı üzerindeki önemini indirekt yoldan göstermesi açısından önemlidir (13 Güçlü bir adrenerjik antogonistir, seratonerjik ve histaminerjik reseptörlere etki eder. Klorpromazinin özellikle antidopaminerjik etkisi migren ve GTBA'daki etkisini açıklayabilir.…”

Section: Discussionunclassified

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Parkinson Hastalığı ve Baş Ağrısı

Şen¹,

Tunç²,

İnan³

2014

tnd

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Ge lifl Ta ri hi/Re cei ved: 27.10.2013 Ka bul Ta ri hi/Ac cep ted: 17.03.2014 Amaç: İdiopatik Parkinson hastalığı tanısı ile izlenen hastalarda baş ağrısı yakınmasının etiyolojisi ve sıklığı incelendi. Gereç ve Yöntem: Çalışmaya polikliniğimizde idiopatik Parkinson hastalığı tanısı alan 60 hasta ve kontrol grubu olarak benzer yaş ve cinsiyette 100 sağlıklı kişi dahil edildi. Bulgular: İdiopatik Parkinson hastalığının 26'sında (%43,3) baş ağrısı saptandı. Baş ağrısı olan ve olmayan hastaların yaşları arasında anlamlı bir fark yoktu. Hastalığın süresi, baş ağrısı olmayan hastalarda baş ağrısı olanlarla karşılaştırıldığında anlamlı derecede uzun bulundu. Sonuç: İdiopatik Parkinson hastalığında baş ağrısı sıklığı, sağlıklı popülasyondan fazla değildir. (Türk Nöroloji Dergisi 2014; 20:37-40) Anah tar Ke li me ler: Parkinson hastalığı, başağrısı, gerilim tipi başağrısı Objective: The etiology and frequency of headache complaint were examined in patients diagnosed with idiopathic Parkinson's disease. Material and Method: 60 patients diagnosed with idiopathic Parkinson's disease in policlinic and a healthy control group of 100 people of similar age and sex were included in the study.Results: Headache was found in 26 of the patients (43.3%) with idiopathic Parkinson's disease. There was not a significant difference between the ages of patients with and without headache. The duration of the disease was significantly longer in the patients without headache when compared to those with headache. Conclusion:The frequency of headache in patients with idiopathic Parkinson's disease is not higher than the healthy population. (Turkish Journal of Neurology 2014; 20:37-40)

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“…GTBA en sık rastlanan baş ağrısı tipidir ve hayat boyu prevalansı %8 olarak bildirilmiştir (13). Çalışmamızda GTBA, diğer tip baş ağrılarına göre daha sıktı.…”

Section: Discussionunclassified

Parkinson Hastalığı ve Baş Ağrısı

Şen¹,

Tunç²,

İnan³

2014

tnd

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“…These authors reported an NNT of two versus placebo for achieving a pain free state by 60 minutes. 2 Cicek et.al. randomized 140 patients with acute tension-type headache to receive either metoclopramide 10 mg IV alone, metoclopramide 10 mg IV + pethidine (meperidine) 50 mg IM, pethidine 50 mg IM alone, or placebo.…”

Section: Discussionmentioning

confidence: 99%

“…1 . Several studies have also demonstrated efficacy of parenteral dopaminergic antagonists such as chlorpromazine 2 and metoclopramide 3 for these headaches. Comparative efficacy studies of the dopamine antagonists versus the non-steroidals have yet to be performed.…”

Section: Introductionmentioning

confidence: 99%

A Randomized Trial of Intravenous Ketorolac Versus Intravenous Metoclopramide Plus Diphenhydramine for Tension-Type and All Nonmigraine, Noncluster Recurrent Headaches

Friedman

Adewunmi

Campbell

et al. 2013

Annals of Emergency Medicine

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Objective We compared metoclopramide 20 mg IV, combined with diphenhydramine 25 mg IV, to ketorolac 30 mg IV in adults with tension-type headache and all non-migraine, non-cluster recurrent headaches. Methods In this ED-based randomized, double-blind study, we enrolled adults with non-migraine, non-cluster recurrent headaches. Patients with tension-type headache were a subgroup of special interest. Our primary outcome was a comparison of the improvement in pain score between baseline and one hour later, assessed on a 0 to 10 verbal scale. We defined a between-group difference of 2.0 as the minimum clinically significant difference. Secondary endpoints included: 1) need for rescue medication in the ED; 2) achieving headache freedom in the ED and sustaining it for 24 hours; and 3) patient’s desire to receive the same medication again. Results We included 120 patients in the analysis. The metoclopramide/diphenhydramine arm improved by a median of 5 (IQR 3,7) scale units while the ketorolac arm improved by a median of 3 (IQR 2,6) (95%CI for difference: 0, 3). Metoclopramide + diphenhydramine were superior to ketorolac for all three secondary outcomes: the number needed to treat for not requiring ED rescue medication was 3 (95%CI: 2, 6), for sustained headache freedom 6 (95%CI: 3, 20), and for wish to receive the same medication again 7 (95%CI: 4, 65). Tension-type headache subgroup results were similar. Conclusions For adults who presented to an ED with tension-type headache or with non-migraine, non-cluster recurrent headache, IV metoclopramide + diphenhydramine provided more headache relief than IV ketorolac.

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“…The intravenous administration of dipyrone (1000 mg) [120,121] and chlorpromazine (0.1 mg/kg) [122], and the intramuscular form of ketorolac (60 mg) [117] have also proved to be effective for the acute treatment of TTH.…”

Section: Acute Pharmacological Treatmentmentioning

confidence: 99%

Tension-type headache

Speciali

Éckeli

Dach

2008

Expert Review of Neurotherapeutics

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Tension-type headache (TTH) is the most prevalent of all headaches and also represents one of the most expensive clinical conditions for the health system. Despite the high impact of this disorder and the existence of well-established diagnostic criteria, knowledge about TTH is still quite limited. In most cases in which crises are quite sporadic, the patients call this normal headache. However, there is a group of patients with the chronic subtype of this headache whose quality of life is greatly compromised. According to the second edition of the International Classification of Headache Disorders, TTH is a bilateral headache of the tight band of pressure type of mild-to-moderate intensity that does not worsen with routine physical activities and whose associated symptoms are less intense than those observed in migraine. Its physiopathology still awaits better elucidation but the existence of central and peripheral mechanisms is already recognized. From a therapeutic viewpoint, simple analgesics are used for the acute treatment of the condition, and tricyclic antidepressants are the most effective class of drugs for its prevention. Follow-up of these patients over the years has demonstrated that the course of TTH is quite favorable in most cases.

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Intravenous chlorpromazine in the acute treatment of episodic tension-type headache: a randomized, placebo controlled, double-blind study

Cited by 18 publications

References 15 publications

Parkinson Hastalığı ve Baş Ağrısı

Parkinson Hastalığı ve Baş Ağrısı

A Randomized Trial of Intravenous Ketorolac Versus Intravenous Metoclopramide Plus Diphenhydramine for Tension-Type and All Nonmigraine, Noncluster Recurrent Headaches

Tension-type headache

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