Intravenous Clonidine Treatment in Acute Myocardial Infarction (with Comparison to a Nitroglycerin-Treated and Control Group)

Zochowski, R J; Lada, W

doi:10.1097/00005344-198608003-00010

Cited by 10 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to its cardioprotective effects during surgical procedures characterized by high SNS stimulation, clonidine has also proved to present anti-ischemic effects in the setting of nonsurgical patients with coronary artery disease [33]. In fact, low doses of clonidine reduce the ischemic ECG alterations observed during the acute phase of myocardial infarction [34,35] and improve exercise tolerance in patients with chronic stable effort angina pectoris [36,37]. Thus, besides their classical antihypertensive properties, clonidine-like drugs present protective actions towards cardiac events induced by sympathetic overactivity and could be potentially useful in the protection of patients with ischemic heart disease.…”

Section: Discussionmentioning

confidence: 99%

Reduced Hemodynamic Responses to Physical and Mental Stress Under Low-Dose Rilmenidine in Healthy Subjects

Castro

Tibiriçá

Oliveira

et al. 2006

Cardiovasc Drugs Ther

View full text Add to dashboard Cite

Activation of the sympathetic nervous system plays a major role in the pathogenesis and prognosis of cardiovascular diseases. Rilmenidine is an I(1)-imidazoline receptor agonist that reduces blood pressure by modulation of central sympathetic activity, but the effects of low-dose rilmenidine on the hemodynamic responses to physiological maneuvers that increase adrenergic drive is not known. To assess the effects of low-dose rilmenidine on the hemodynamic responses to stress, 32 healthy subjects (20-56 years old) underwent acute physical exercise (n = 15, individualized ramp protocol on treadmill) and mental stress (n = 17, word color Stroop and mental arithmetics tests) two hours after the oral administration of 0.5 mg of rilmenidine (RIL) or placebo (PLA) following a randomized, double-blind, placebo controlled crossover study. No subject complained of any side effect. Rilmenidine reduced peak exercise heart rate (PLA: 187 +/- 7; RIL: 181 +/- 9 bpm; P = 0.003), but did not modify peak aerobic power (VO(2max) - PLA: 41.7 +/- 6.2; RIL: 42.3 +/- 6.7 ml/kg/min; P = 0.26). During mental stress, rilmenidine inhibited the peak systolic (PLA: 123 +/- 10; RIL: 114 +/- 8 mmHg; P = 0.02) and diastolic (PLA: 86 +/- 7; RIL: 81 +/- 7 mmHg; P <0.05) blood pressure responses. In conclusion, rilmenidine reduced the hemodynamic response to physical and mental stress stimuli without limiting exercise capacity. These results support the concept that rilmenidine, at a dose lower than the ones recommended to treat hypertension, reduced the myocardial oxygen demand to stress and may carry potential clinical impact.

show abstract

Section: Discussionmentioning

confidence: 99%

Reduced Hemodynamic Responses to Physical and Mental Stress Under Low-Dose Rilmenidine in Healthy Subjects

Castro

Tibiriçá

Oliveira

et al. 2006

Cardiovasc Drugs Ther

View full text Add to dashboard Cite

show abstract

Effect of early treatment with anti-hypertensive drugs on short and long-term mortality in patients with an acute cardiovascular event

Perez

Musini

Wright

2009

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Nitrates reduce mortality (4-8 deaths prevented per 1000) at 2 days when administered within 24 hours of symptom onset of an acute myocardial infarction. No mortality benefit was seen when treatment continued beyond 48 hours. Mortality benefit of immediate treatment with ACE inhibitors post MI at 2 days did not reach statistical significance but the effect was significant at 10 days (2-4 deaths prevented per 1000). There is good evidence for lack of a mortality benefit with immediate or short-term treatment with beta-blockers and calcium channel blockers for acute myocardial infarction.

show abstract

Clonidine does not affect lidocaine seizure threshold in rats

1993

View full text Add to dashboard Cite

We investigated the effect of clonidine on intravenous (iv) lidocaine-induced haemodynamic changes and convulsions in awake rats. Wistar rats (200-250 g) were divided into three groups of eight and were pretreated with iv clonidine or normal saline 15 rain before lidocaine infusion. Group 1 received normal saline; Group 2, and Group 3, (Group 1:10.5 + 0.3, Group 2:10.8 5: 0.3, respectively (groupe I: 41,8 5: 2,2; groupe 2:43,8 • 2,3; groupe 3:42,3 + 2 rag" kg -t) (groupe 1:10,5 -t-0,3; groupe 2:10,8 4-0,3; groupe 3:10,6 + 0,3 ttg" ml-J) ni les concentrations plasmatiques de lidoca?ne ddclenchant les convulsions

show abstract

Intravenous Clonidine Treatment in Acute Myocardial Infarction (with Comparison to a Nitroglycerin-Treated and Control Group)

Cited by 10 publications

References 0 publications

Reduced Hemodynamic Responses to Physical and Mental Stress Under Low-Dose Rilmenidine in Healthy Subjects

Reduced Hemodynamic Responses to Physical and Mental Stress Under Low-Dose Rilmenidine in Healthy Subjects

Effect of early treatment with anti-hypertensive drugs on short and long-term mortality in patients with an acute cardiovascular event

Clonidine does not affect lidocaine seizure threshold in rats

Contact Info

Product

Resources

About