Intravenous Dexmedetomidine Has Synergistic Effect on Subarachnoid Block with Hyperbaric Bupivacaine

Furqan, Aamir; Mohsin, Muhammad Usman; Sattar, Muhammad Kaleem; Khan, Ali; Shahid, Muhammad; Fayyaz, Aatir

doi:10.7759/cureus.6051

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…Generally, respiratory suppression induced by DEX is lesser than that induced by other sedation agents [11]. There are also two reports that the combined use of DEX with local anaesthesia prolonged the effect of the local anaesthetic [12,13]. Although it is not a common method of administration and is still in the research stage, there is a report that DEX administered into the subarachnoid region of the spinal cord produced a mild sedative effect while enhancing the effects of spinal anaesthesia [14].…”

Section: Discussionmentioning

confidence: 99%

Successful Management of Parkinson's Disease Dyskinesia During Local Anesthesia With Dexmedetomidine

Nakajima

Suzuki

Miyaue

2021

Cureus

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Section: Discussionmentioning

confidence: 99%

Successful Management of Parkinson's Disease Dyskinesia During Local Anesthesia With Dexmedetomidine

Nakajima

Suzuki

Miyaue

2021

Cureus

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Comparison of the Effect of Intrathecal Hyperbaric 0.5% Bupivacaine Alone and With Addition of Dexemedetomidine on First Analgesic Request in Post-Operative Care Unit Following Elective Cesarean Section

Shahid¹,

Sibtain²,

Islam³

et al. 2022

PBMJ

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Spinal anesthesia has been considered preferred method of anesthesia for patients undergoing elective cesarean sections. Dexmedetomidine (DXM) is relatively a newer drug in Pakistan as compared to conventional used drug i.e. Bupivacaine (BPV) and that’s why the local data regarding its efficacy in cesarean section is lacking. Objective: To compare the mean duration of spinal anasthesia between hyperbaric bupivacaine 0.5% alone versus hyperbaric bupivacaine 0.5% with dexmedetomidine on first analgesic request for women undergoing elective cesarean section under subarachnoid block Methods: Spinal anesthesia was performed in the sitting position under sterile conditions with 25G pencil point needle. After successful intra thecal injection, patient was placed in the supine position with left tilt. The cases in Group A received hyperbaric 0.5% BPV (2.25ml) with 5ug DXM (0.25ml) and those in Group B received only 0.5% BPV (2.25ml) with 0.25ml normal saline under full aseptic measures. These patients underwent cesarean section and were assessed in post-operative time after every 30 minutes to first request of analgesia which were given if there was pain of 4 or more on visual analogue scale. Results: In Group A, mean and SDs for duration of analgesia was 359.73+8.021 minutes. In Group B, mean and SDs for duration of analgesia was 182.30+7.720 minutes Conclusions: In this study, hyperbaric bupivacaine 0.5% with DXM in spinal anesthesia for patients undergoing caesarean section significantly prolonged the duration of analgesia

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Comparison of The Effect of Intrathecal Hyperbaric 10.5% Bupivacaine Alone And With Addition of Dexmedetomidine On First Anlgesic request In Post Operative Care Unit Following Elective Cesarean Section In Association To Body Mass Index And Duration of Analgesia

Shahid¹,

Islam²,

Ahmad³

et al. 2022

PBMJ

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For patients undergoing elective cesarean, spinal anesthesia has been considered a preferred method of anesthesia. Conventionally, Bupivacaine was used but now dexemetomidine, a newer drug as compared to Bupivacaine is being used. Due to short usage tenure of dexemetomidine as a spinal anesthesia, data regarding its afficacy is lacking in Pakistan.Objectives: To compare the mean duration of spinal anasthesia between hyperbaric bupivacaine 0.5% alone versus hyperbaric bupivacaine 0.5% with dexmedetomidine on first analgesic request for women undergoing elective cesarean section alongwith examining the affect of BMI on Dexemedetomidine. Methods: Spinal anesthesia was administered in the sitting position under sterile conditions with 25G pencil point needle. Patient was positioned in a supine position tilting towards left after successful intra thecal injection. Group A cases received hyperbaric 0.5% BPV (2.25ml) with 5ug DXM (0.25ml) and those in Group B received only 0.5% BPV (2.25ml) with 0.25ml normal saline under full aseptic measures. These patients underwent cesarean section and were assessed in post-operative time after every 30 minutes to first request of analgesia which were given if there was pain of 4 or more on visual analogue scale. Results: In Group A, mean and SDs for duration of analgesia was 359.73+8.021 minutes. In Group B, mean and SDs for duration of analgesia was 182.30+7.720 minutes. Results depicted mean and SD for BMI of the patients to be 25.66+1.52. Conclusion: In this study, hyperbaric bupivacaine 0.5% with DXM in spinal anesthesia for patients undergoing caesarean section significantly prolonged the duration of analgesia in normal to slightly overweight individuals.

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Intravenous Dexmedetomidine Has Synergistic Effect on Subarachnoid Block with Hyperbaric Bupivacaine

Cited by 3 publications

References 18 publications

Successful Management of Parkinson's Disease Dyskinesia During Local Anesthesia With Dexmedetomidine

Successful Management of Parkinson's Disease Dyskinesia During Local Anesthesia With Dexmedetomidine

Comparison of the Effect of Intrathecal Hyperbaric 0.5% Bupivacaine Alone and With Addition of Dexemedetomidine on First Analgesic Request in Post-Operative Care Unit Following Elective Cesarean Section

Comparison of The Effect of Intrathecal Hyperbaric 10.5% Bupivacaine Alone And With Addition of Dexmedetomidine On First Anlgesic request In Post Operative Care Unit Following Elective Cesarean Section In Association To Body Mass Index And Duration of Analgesia

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