Intravenous Fluid Replacement Therapy and Hospital Outcomes for Vaso-Occlusive Episodes in Patients with Sickle Cell Disease

Haimed, Abraham; Weiss, Rebecca; Kwon, Soyang; Bhat, Rukhmi; Badawy, Sherif M.

doi:10.1182/blood-2022-159715

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was found that during the first 3 days of admission, hospital length of stay increased by 0.53 days for each additional 0.5 times the mIVF rate (p < .001; 95% confidence interval (CI): 0.609-0.989), suggesting that excessive fluid administration during a VOE in SCD patients is associated with a prolonged hospital stay. Normal saline with 5% dextrose was used as maintenance fluid in the majority of patients in the study [ 11 ].…”

Section: Reviewmentioning

confidence: 99%

“…Although hydration has been dogmatically considered an essential component of the management of sickle cell crisis, consensus regarding the effectiveness of intravenous fluid (IVF) therapy has not been established. Additionally, potential risks of the intervention including fluid overload, and pulmonary edema may lead to transfer to the intensive care unit (ICU) and increased length of hospital stay [ 8 - 11 ]. We conduct this review as an attempt to summarize the available evidence on the role and utility of intravenous hydration in sickle cell crises along with reported adverse outcomes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Intravenous Hydration and Associated Outcomes in Patients With Sickle Cell Disease Admitted With Vaso-Occlusive Crises: A Systematic Review

Pandey,

Tan,

Bellamkonda

et al. 2024

Cureus

View full text Add to dashboard Cite

Acute painful vaso-occlusive crisis (VOC) is the common presentation of sickle cell disease (SCD) leading to emergency room visits, admissions, morbidity, mortality, and negative impacts on quality of life. Among various treatment approaches commonly employed to manage the condition, intravenous (IV) hydration is also frequently used in emergency and inpatient settings. Although helpful to overcome dehydration, IV hydration often leads to adverse outcomes like fluid overload, pulmonary edema, increased length of stay, transfer to intensive care unit, new oxygen requirement, etc. Small-scale retrospective studies are conducted to study the outcomes of IV hydration but have failed to conclusively demonstrate its benefits as well as choice of IV fluids, rate of IV fluid replacement, etc. We conduct this review as an attempt to summarize the available evidence on the role and utility of IV hydration in sickle cell crises along with reported adverse outcomes.

show abstract

Section: Reviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%