Intravenous glucose after out‐of‐hospital cardiopulmonary arrest

Longstreth, W. T.; Copass, Michael K.; Dennis, Leslie K.; Rauch-Matthews, M. E.; Stark, Michelle; Cobb, Leonard A.

doi:10.1212/wnl.43.12.2534

Cited by 83 publications

(24 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most human and animal studies of fluid infusion during CPR did not have a control group, [332][333][334][335][336][337][338][339][340][341][342][343] and 2 animal studies showed that normothermic fluid infusion during CPR caused a decrease in CPP. 344 -346 In addition to normothermic fluid, hypertonic and chilled fluids have been studied in animal and small human studies without a survival benefit.…”

Section: Fluidsmentioning

confidence: 99%

Part 8: Adult Advanced Cardiovascular Life Support

Neumar¹,

Otto²,

Link³

et al. 2010

Circulation

1,348

872

View full text Add to dashboard Cite

Section: Fluidsmentioning

confidence: 99%

Part 8: Adult Advanced Cardiovascular Life Support

Neumar¹,

Otto²,

Link³

et al. 2010

Circulation

1,348

872

View full text Add to dashboard Cite

“…In global cerebral isch emia, as seen in cardiac arrest survivors, elevated admission blood glucose levels are a prognostic indi cator, but seem to be more the sequel of prolonged CPR than the cause of adverse neurological outcome (Longstreth and Inui, 1984;Longstreth et al 1986Longstreth et al , 1993. In a study by Longstreth et al (1993), patients with out-of-hospital cardiac arrest were randomized to receive either 5% dextrose in water or half normal saline intravenously after the event. Overall, there was no difference in outcome between the groups.…”

Section: Discussionmentioning

confidence: 99%

Blood Glucose Concentration after Cardiopulmonary Resuscitation Influences Functional Neurological Recovery in Human Cardiac Arrest Survivors

Müllner¹,

Sterz²,

Binder

et al. 1997

J Cereb Blood Flow Metab

139

View full text Add to dashboard Cite

Experimental data suggest that postischemic blood glucose concentration plays an important role in modulating both ischemic cerebral infarction and selective neuronal necrosis. This study investigated the association between functional neurological recovery and blood glucose concentrations in human cardiac arrest survivors. A group of 145 nondiabetic patients were evaluated after witnessed ventricular fibrillation cardiac arrest. Data regarding cardiac arrest were collected according to an internationally accepted protocol immediately after arrival. Blood glucose was measured on admission and 6, 12, and 24 h thereafter. To control for duration of cardiac arrest and cardiogenic shock, both known to influence outcome as well as blood glucose, levels, Spearman rank partial correlation was used. In this multivariate analysis, a high admission blood glucose level tended to be associated with poor neurological outcome ( rs = −0.16, n = 142, p = 0.06). The association between high median blood glucose levels over 24 h and poor neurological outcome was strong and statistically significant ( rs = −0.2, n = 145, p = 0.015). High blood glucose concentrations occurring over the first 24 h after cardiac arrest have deleterious effects on functional neurological recovery. Whether cardiac arrest survivors might benefit from reduction of blood glucose levels needs further investigation.

show abstract

“…10,[65][66][67][68][69][70] Animal studies suggest that elevated postischemic blood glucose concentrations exacerbate ischemic brain injury, 71,72 and this effect can be mitigated by intravenous insulin therapy. 73,74 Seizures in the post-cardiac arrest period are associated with worse prognosis and are likely to be caused by, as well as exacerbate, post-cardiac arrest brain injury.…”

Section: Post-cardiac Arrest Brain Injurymentioning

confidence: 99%