“…12,13 High doses of vitamin C decrease intraocular pressure, probably by depolymerizing the TM's hyaluronic acid component. 14,15 Another antioxidant agent that plays a major role in eye defense is reduced glutathione, a tripeptide composed of the amino acids ␥-glutamic acid, cysteine, and glycine. Glutathione participates directly in the neutralization of free radicals and reactive oxygen species (ROS) and maintains exogenous antioxidants, such as vitamins C and E. Thus, glutathione protects ocular tissues from the damage induced by low H 2 O 2 concentrations, whereas catalase protects ocular tissues from the damage induced by high H 2 O 2 concentrations.…”