1966
DOI: 10.1016/0002-9394(66)91905-2
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Intravenous Glycerol-Vitamin C (Sodium Salt) as Osmotic Agents to Reduce Intraocular Pressure

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1966
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Cited by 24 publications
(10 citation statements)
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“…Our results led us to speculate that reduction of vitamin C levels may cause IOP elevation and glaucomatous optic neuropathy even in NTG patients. Considerable reductions in IOP have also been observed in glaucoma patients after administration of vitamin C in some studies [28][29][30]. Vitamin C may reduce IOP by the depolymerization of the trabecular meshwork`s hyaluronic acid component [30].…”
Section: Discussionmentioning
confidence: 98%
“…Our results led us to speculate that reduction of vitamin C levels may cause IOP elevation and glaucomatous optic neuropathy even in NTG patients. Considerable reductions in IOP have also been observed in glaucoma patients after administration of vitamin C in some studies [28][29][30]. Vitamin C may reduce IOP by the depolymerization of the trabecular meshwork`s hyaluronic acid component [30].…”
Section: Discussionmentioning
confidence: 98%
“…12,13 High doses of vitamin C decrease intraocular pressure, probably by depolymerizing the TM's hyaluronic acid component. 14,15 Another antioxidant agent that plays a major role in eye defense is reduced glutathione, a tripeptide composed of the amino acids ␥-glutamic acid, cysteine, and glycine. Glutathione participates directly in the neutralization of free radicals and reactive oxygen species (ROS) and maintains exogenous antioxidants, such as vitamins C and E. Thus, glutathione protects ocular tissues from the damage induced by low H 2 O 2 concentrations, whereas catalase protects ocular tissues from the damage induced by high H 2 O 2 concentrations.…”
mentioning
confidence: 99%
“…Virno et al 20 recorded no adverse reactions using a 30% intravenous glycerin solution in the treatment of glaucoma at rates of 0.6 g/kg over a single 15‐ to 20‐minute dose, and in the extensive review by Frank et al, 5 no significant toxicity was noted at glycerin doses of 2.0 g/kg of intravenous infusion over 2 hours. In our study, the 72% glycerin solution, when diluted with lidocaine, yields a solution of 0.48 g glycerin/mL and a total delivered dose of 4.8 g of glycerin at the recommended volume (10 mL) of sclerosant.…”
Section: Discussionmentioning
confidence: 99%
“…Intravenous glycerol has primarily been used clinically for its potent osmotic dehydrating effect. Glycerin in doses of 0.25 to 2.0 g/kg dramatically decreases intracranial pressure for the treatment of stoke, pseudotumor cerebri, encephalitis, and space occupying lesions and is effective in rapidly lowering intraocular pressure in glaucoma 5,19,20 . Notable adverse reactions of glycerin in humans include intravascular hemolysis, hemoglobinuria, renal damage, hyperglycemia, and hyperosmolality.…”
Section: Discussionmentioning
confidence: 99%