2010
DOI: 10.1542/neo.11-7-e370
|View full text |Cite
|
Sign up to set email alerts
|

Intravenous Immune Globulin: Clinical Applications in the Newborn

Abstract: Intravenous immune globulin (IVIG) is manufactured from plasma isolated from healthy blood donors and includes mostly immunoglobulin G (IgG). IVIG is approved by the United States Food and Drug Administration (FDA) for use in a variety of diseases in adults and children, although there are no FDA-approved uses of IVIG in newborns. Off-label use of IVIG in newborns includes prophylaxis against infections in low-birthweight infants and treatment of neonatal alloimmune diseases such as hemolytic disease of the ne… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
7
0

Year Published

2010
2010
2023
2023

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 7 publications
(8 citation statements)
references
References 37 publications
0
7
0
Order By: Relevance
“…Some authors have implied that the key to a successful treatment is the early administration of the immunoglobulin, as soon as the diagnosis of hemolytic anemia. Neonates tolerated well the high dose of IVIG without apparent drug-related adverse events, in contrast to others where necrotizing enterocolitis in newborns with hemolytic disease has been detected [8,26].…”
Section: Discussionmentioning
confidence: 67%
See 2 more Smart Citations
“…Some authors have implied that the key to a successful treatment is the early administration of the immunoglobulin, as soon as the diagnosis of hemolytic anemia. Neonates tolerated well the high dose of IVIG without apparent drug-related adverse events, in contrast to others where necrotizing enterocolitis in newborns with hemolytic disease has been detected [8,26].…”
Section: Discussionmentioning
confidence: 67%
“…The use of IVIG has declined the number of infants needing exchange transfusion, as suggested by many studies [23,26,30]. The benefits of IVIG therapy appear to be related to the blockage of Fc receptors in the neonatal reticuloendothelial system [11].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…IVIG clinical applications and indications have expanded rapidly in recent years [ 6 , 7 ]. Several of these clinical applications have extended to include children, neonates, and fetuses [ 8 , 9 ]. Although the Food and Drug Administration (FDA) has not yet approved IVIG therapy for use in the neonate, it has been used off-label in the management of challenging and progressing conditions in many fetuses and neonates [ 9 ].…”
Section: Introductionmentioning
confidence: 99%
“…Intravenous Immunoglobulin (IVIG) is a blood product manufactured from plasma pooled from more than 1,000 healthy blood donors and includes mostly IgG, although traces of IgA may also be present. 1 Across all age groups the usage of IVIG is increasing with better understanding of many disease processes having immunological basis. There are a very few well defined indications for usage of IVIG in neonates due to limited number of research trials.…”
Section: Introductionmentioning
confidence: 99%