2023
DOI: 10.1111/aji.13737
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Intravenous immunoglobulin use in patients with unexplained recurrent pregnancy loss

Abstract: Problem Recurrent pregnancy loss (RPL) affects up to 4% of couples attempting to conceive. RPL is unexplained in over 50% of cases and no effective treatments exist. Due to the immune system's pivotal role during implantation and pregnancy, immune‐mediated RPL may be suspected and immunomodulatory treatments like intravenous immunoglobulin (IVIg) have been administered but remain controversial. The goal of our study was to evaluate our center's 6 year‐outcomes and to develop a framework for IVIg use in RPL. Me… Show more

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Cited by 9 publications
(1 citation statement)
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“…In the context of pregnancy, while the production of natural and protective antibodies is related to pregnancy success ( 81 , 82 ), the presence of autoantibodies is associated with RPL ( 8 ). There is growing evidence suggesting that ANAs can play a role in both early pregnancy complications, such as embryo implantation, and pregnancy loss ( 83 ).…”
Section: B-cell Activation and Autoantibody Production In Lupus: Impa...mentioning
confidence: 99%
“…In the context of pregnancy, while the production of natural and protective antibodies is related to pregnancy success ( 81 , 82 ), the presence of autoantibodies is associated with RPL ( 8 ). There is growing evidence suggesting that ANAs can play a role in both early pregnancy complications, such as embryo implantation, and pregnancy loss ( 83 ).…”
Section: B-cell Activation and Autoantibody Production In Lupus: Impa...mentioning
confidence: 99%