Intravenous in-line filters for preventing morbidity and mortality in neonates

Foster, Jann P; Richards, Robyn; Showell, Marian; Jones, Lisa J

doi:10.1002/14651858.cd005248.pub3

Cited by 30 publications

(22 citation statements)

References 35 publications

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“…Furthermore, in-line IV filters add cost [ 19 – 21 ]. Some reports have suggested the benefit of in-line IV filters [ 1 , 20 , 22 , 23 ], whereas other reports have rejected their routine use [ 3 , 24 – 26 ]. To date, the routine use of in-line IV filters is not standard.…”

Section: Discussionmentioning

confidence: 99%

IV injection of polystyrene beads for mouse model of sepsis causes severe glomerular injury

et al. 2014

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BackgroundInfusion fluids may be contaminated with different types of particulates that are a potential health hazard. Particulates larger than microvessels may cause an embolism by mechanical blockage and inflammation; however, it has been reported that particulates smaller than capillary diameter are relatively safe. Against such a background, one report showed that polystyrene beads smaller than capillary diameter decreased tissue perfusion in ischemia–reperfusion injury. This report suggested that polystyrene beads from 1.5- to 6-μm diameter (dia.) may have unfavorable effects after pretreatment.Here, we investigated whether injection of polystyrene beads (3- and 6-μm dia.) as an artificial contaminant of intravenous fluid after lipopolysaccharide (LPS) injection affected mortality and organ damage in mice.MethodsMice were divided into four groups and injected: polystyrene beads only, LPS only, polystyrene beads 30 min after LPS, or saline. A survival study, histology, blood examination, and urine examination were performed.ResultsThe survival rate after LPS and polystyrene bead (6-μm dia.) injection was significantly lower than that of the other three groups. In the kidney sections, injured glomeruli were significantly higher with LPS and polystyrene bead injection than that of the other three groups. LPS and polystyrene bead injection decreased the glomerular filtration rate and led to renal failure. Inflammatory reactions induced with LPS were not significantly different between with or without polystyrene beads. Polystyrene beads were found in urine after LPS and polystyrene bead injection.ConclusionsInjection of polystyrene beads after LPS injection enhanced glomerular structural injury and caused renal function injury in a mouse sepsis model.

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Section: Discussionmentioning

confidence: 99%

IV injection of polystyrene beads for mouse model of sepsis causes severe glomerular injury

et al. 2014

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“…63 For instance, in-line filters did not significantly influence the incidence of bloodstream infections, phlebitis, morbidity, and mortality. [64][65][66] Nevertheless, according to most national recommendations in Europe, there is a role for the use of in-line filtration of TNA for patients who require intensive parenteral therapy; the immunocompromised, neonates, and children might have increased susceptibility to the detrimental effects of particulate contamination and therefore can benefit from the use of filters during the administration of PN. 31,33,[67][68][69] In such cases, 0.22-μm filters should be used for lipid-free admixtures and 1.2-μm filters for lipidcontaining admixtures.…”

Section: Ile Administrationmentioning

confidence: 99%

Use of Intravenous Lipid Emulsions With Parenteral Nutrition: Practical Handling Aspects

Boullata

Berlana

Piętka³

et al. 2020

J Parenter Enteral Nutr

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A number of topics important to the handling of intravenous lipid emulsions (ILEs) were discussed at the international summit. ILE handling includes the preparation and the administration steps in the typical use of parenteral nutrition (PN). The discussion and consensus statements addressed several issues, including standardization of the PN process, use of commercially available multi‐chamber PN or compounded PN bags, the supervision by a pharmacist with expertise, limiting ILE repackaging, and infusion duration.

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“…The administration of these particles can have serious consequences for the patient, as endothelial lesions and thrombosis [21,22], and the use of inline filters has been shown to reduce the number of general complications and Systemic Inflammatory Response Syndrome (SIRS) [23]. However, a recent meta-analysis did not reveal a significant effect of online filters on overall mortality in pediatrics/neonatology [24]. Not all drugs are filterable, such as suspensions, micellar solutions, liposomes, having a high viscosity or a risk of adsorption on the filter membrane.…”

Section: Factorsmentioning

confidence: 99%

Avoid Drug Incompatibilities: Clinical Context in Neonatal Intensive Care Unit (NICU)

Flamein

Storme

Maiguy-Foinard

et al. 2017

Pharmaceutical Technology in Hospital Pharmacy

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AbstractThe administration of several intravenous products on the same catheter is a very common situation in neonatology, where the stakes are high and the dangers sometimes unknown to clinicians. A large number of factors are involved in this administration, directly related to the installation of the infusion line. Moreover, the therapeutics used are often limited, and excluding classic “Marketing Authorization”. Some of these products may prove to be incompatible and thus lose their effectiveness, or even generate particles that are likely to be administered to the patient. We must be aware of these risks in order to optimize the prescription and administration of these intravenous products, especially as we treat fragile and immature patients. The aim of this work is to review the literature on the subject for the prescribers of neonatology units.

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Intravenous in-line filters for preventing morbidity and mortality in neonates

Cited by 30 publications

References 35 publications

IV injection of polystyrene beads for mouse model of sepsis causes severe glomerular injury

IV injection of polystyrene beads for mouse model of sepsis causes severe glomerular injury

Use of Intravenous Lipid Emulsions With Parenteral Nutrition: Practical Handling Aspects

Avoid Drug Incompatibilities: Clinical Context in Neonatal Intensive Care Unit (NICU)

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