Intravenous infusion of amino acids in dogs attenuates hypothermia during anaesthesia and stimulates insulin secretion

Takashima, S; Shibata, Sanae; Yamada, Kazuto; Ogawa, Midori; Nishii, Naohito; Kitagawa, Hitoshi

doi:10.1111/vaa.12319

Cited by 5 publications

(13 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We previously demonstrated that amino acid infusion at 1.2 g/kg/hr significantly attenuated the decrease in body temperature during anesthesia in healthy dogs [21]. This finding was interpreted to be the result of the production of heat from muscle protein synthesis via an increase in plasma insulin concentration.…”

Section: Discussionmentioning

confidence: 93%

“…This finding was interpreted to be the result of the production of heat from muscle protein synthesis via an increase in plasma insulin concentration. In our previous study, the body temperature of dogs administered amino acids 120 min following anesthesia induction was 35.5 ± 0.4°C, declining 2.8°C from 38.3 ± 0.3°C at 60 min prior to induction [21]. Moreover, the body temperature of dogs administered acetated Ringer’s solution 120 min following anesthesia induction was 34.3 ± 0.2°C, declining 3.9°C from 38.2 ± 0.3°C at 60 min prior to induction [21].…”

Section: Discussionmentioning

confidence: 99%

“…In our previous study, the body temperature of dogs administered amino acids 120 min following anesthesia induction was 35.5 ± 0.4°C, declining 2.8°C from 38.3 ± 0.3°C at 60 min prior to induction [21]. Moreover, the body temperature of dogs administered acetated Ringer’s solution 120 min following anesthesia induction was 34.3 ± 0.2°C, declining 3.9°C from 38.2 ± 0.3°C at 60 min prior to induction [21]. In the present study, the body temperature of dogs administered amino acids at 120 min following anesthesia induction was 35.5 ± 0.5°C, declining 3.1°C from 38.6°C ± 0.5°C 60 min prior to induction, which is comparable with that seen in our previous study.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, only one amino acid infusion rate was used, since our previous study [21] had revealed an optimal infusion rate of 1.2 g/kg/hr for the attenuation of hypothermia during anesthesia. A 10% amino acid solution (Amiparen, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan) containing a mixture of 18 amino acids that provided 15.65 g nitrogen/l was used as the test solution.…”

Section: Methodsmentioning

confidence: 99%

“…Intraoperative hypothermia in dogs, defined as a temperature of <36.7°C [10], prolongs the recovery time from anesthesia [17] and the time to extubation [18]. We previously demonstrated that amino acid infusion at 1.2 g/kg/hr in healthy dogs significantly attenuates the decrease in body temperature during anesthesia by the facilitation of insulin secretion [21]. Since protein synthesis in skeletal muscle is stimulated by exogenously administered insulin [4, 5, 7], we interpreted the outcome of our previous study to be the result of the production of heat from muscle protein synthesis induced by insulin secretion.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Effect of cyclooxygenase-2 inhibitors at therapeutic doses on body temperature during anesthesia in healthy dogs administered with amino acids

Takashima

Takitani

Kitamura

et al. 2019

The Journal of Veterinary Medical Science

Self Cite

View full text Add to dashboard Cite

In healthy dogs, amino acid infusion significantly attenuates the decrease in body temperature during anesthesia by facilitating insulin secretion, suggesting that such an increase in insulin secretion is related to increased heat production. In dogs, selective cyclooxygenase-2 (COX-2) inhibitors, which are used for pain relief in veterinary medicine, possess anti-pyretic action. And, in mice and humans, selective COX-2 inhibitors increase insulin secretion and sensitivity. Therefore, treatment with COX-2 inhibitors may negate or accelerate the attenuating effect on decreased body temperature during anesthesia by amino acid infusion. In the present study, influences on insulin secretion and body temperature by treatment with meloxicam or robenacoxib at therapeutic dose were evaluated in healthy dogs. Treatment with meloxicam or robenacoxib did not affect insulin secretion in the unanesthetized and anesthetized dogs, and did not affect body temperature and heart rate under the anesthetized condition with amino acid infusion. In conclusion, COX-2 inhibitors at therapeutic doses did not affect body temperature during anesthesia in dogs administered amino acids.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Effect of cyclooxygenase-2 inhibitors at therapeutic doses on body temperature during anesthesia in healthy dogs administered with amino acids

Takashima

Takitani

Kitamura

et al. 2019

The Journal of Veterinary Medical Science

Self Cite

View full text Add to dashboard Cite

show abstract

Effect of a single intravenous injection of branched chain amino acids on body temperature of cats undergoing general anesthesia

Sakata,

Clark-Price,

Johnson

et al. 2024

Veterinary Anaesthesia and Analgesia

View full text Add to dashboard Cite

Decreased incidence of perioperative inadvertent hypothermia and faster anesthesia recovery with increased environmental temperature: A nonrandomized controlled study

et al. 2019

View full text Add to dashboard Cite

ObjectiveTo determine perioperative inadvertent hypothermia (PIH) incidence, risk factors, prevention methods, and effect of PIH prevention on anesthesia recovery times.Study designNonrandomized controlled before‐and‐after trial.AnimalsDogs (n = 277) and cats (n = 20) undergoing open surgery.MethodsIncidence and risk factors for PIH (core temperature <96.8°F), existing thermal care practices, and recovery times were documented at baseline. For group 1, a thermal care bundle consisting of protocol‐driven active warming combined with raised environmental temperatures (75°F) in induction rooms (IR) and operating rooms (OR) was implemented. Perioperative inadvertent hypothermia incidence and recovery times were recorded. For group 2, baseline active warming practices were resumed while environmental temperatures remained elevated.ResultsPerioperative inadvertent hypothermia was associated with preoperative imaging (P = .039) and percentage clip area (P = .037). Perioperative inadvertent hypothermia decreased in group 1 (13.5%, n = 96, P < .001) and group 2 (13.0%, n = 100, P < .001) compared with baseline (35.6%, n = 101). Median time from anesthesia withdrawal to extubation decreased in group 1 (5 minutes, P = .028) and group 2 (5 minutes, P = .018) compared with baseline (7 minutes). Median time from anesthesia recovery to spontaneous food intake decreased in group 1 (6 hours, n = 92, P = .016) but not in group 2 (6.0 hours, n = 88, P = .060) compared with baseline (n = 94, 6.7 hours). No group differences in PIH risk factors were identified.ConclusionPerioperative inadvertent hypothermia incidence was high but reducible by raising environmental temperatures alone or in combination with increased focus on active warming. Reductions in PIH shortened recovery times.Clinical significanceMaintaining IR and OR temperatures at the standard‐of‐care for human pediatric surgery reduces PIH and may improve outcomes.

show abstract

Intravenous infusion of amino acids in dogs attenuates hypothermia during anaesthesia and stimulates insulin secretion

Cited by 5 publications

References 37 publications

Effect of cyclooxygenase-2 inhibitors at therapeutic doses on body temperature during anesthesia in healthy dogs administered with amino acids

Effect of cyclooxygenase-2 inhibitors at therapeutic doses on body temperature during anesthesia in healthy dogs administered with amino acids

Effect of a single intravenous injection of branched chain amino acids on body temperature of cats undergoing general anesthesia

Decreased incidence of perioperative inadvertent hypothermia and faster anesthesia recovery with increased environmental temperature: A nonrandomized controlled study

Contact Info

Product

Resources

About