Intravenous infusion of ulinastatin attenuates acute kidney injury after cold ischemia/reperfusion

Wang, Yunpeng; Peng, Cheng; Zhang, Zheng; Shi, Jing; Lin, Ying‐Li; Gu, Liangyou; Ma, Xin; Hong-zhao, LI

doi:10.1007/s11255-019-02204-3

Cited by 16 publications

(14 citation statements)

References 34 publications

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“…Eken MK et al indicated that treatment with etanercept restored GSH levels in ovarian from IR rats and increase SOD levels and decrease MDA levels, implicating GSH attenuated oxidative ovarian reserve against IRI in a rat model 43 . Similarly, UTI has been proven to alleviate IRI in the most organs, including heart, lung, and liver by regulating the levels of TNF-a and IL6 28 . Our study had the consistent results that administration of GSH and UTI improve the follicular integrity and viability in the ovarian grafts by regulating antioxidative and antiinflammatory parameters.…”

Section: Discussionmentioning

confidence: 99%

“…IRI in the ovarian grafts related to insufficient perfusion and limitation of the blood flow, increasing the accumulation of oxidative stress and inflammatory cytokine which can lead to huge follicular loss in the ovarian grafts. GSH and UTI have been proved to protect many organs against IRI, such as kidney, liver, heart and brain [28][29][30] . However, the anti-IRI effects of GSH, UTI and GSHþUTI on transplanted ovarian grafts and their mechanism have not been discussed so far.…”

Section: Discussionmentioning

confidence: 99%

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Protective Effects of Reduced Glutathione and Ulinastatin on Xeno-transplanted Human Ovarian Tissue Against Ischemia and Reperfusion Injury

Zhu

et al. 2021

Cell Transplant

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Recently, transplantation of cryopreserved ovarian tissue is the method for fertility preservation for oncologic and nononcologic reasons. The main challenge of ovarian cryopreservation followed by transplantation is that ischemia reperfusion injury (IRI) induced the loss of follicles. The aim of this study was to evaluate the effects of glutathione (GSH), ulinastatin (UTI) or both (GSH+UTI) on preventing ischemia reperfusion-induced follicles depletion in ovarian grafts. Ovarian fragments were collected from 20 women aged 29±6 years. Frozen-thawed human ovarian tissue was xenografted into SCID mice, at the same time GSH, UTI and GSH+UTI was administrated respectively. The ovarian grafts were collected at the 1st, 3rd, 7th, 14th, 28th, 56th, and 85th day after xenotransplantation. Follicle survival rate was measured by H&E staining and Live/Dead staining. Angiogenic activity and macrophage recruitment was evidenced by immunohistochemical staining. The oxidative stress and inflammatory cytokines in human ovarian xenografts were measured by real-time PCR. The results indicated that after the treatments of GSH, UTI and GSH+UTI in the hosts, follicular survival in ovarian grafts were improved. The level of VEGF, CD31, and antioxidant enzymes superoxide dismutase 1 and superoxide dismutase 2 in ovarian grafts were increased. Accumulation of macrophages, level of IL6 and TNF-α, as well as malondialdehyde was decreased in ovarian grafts from treated groups. In conclusion, administration of GSH, UTI and GSH+UTI decreased the depletion of follicles in human grafts post-transplantation by inhibiting IRI-induced antiangiogenesis, oxidative stress and inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Protective Effects of Reduced Glutathione and Ulinastatin on Xeno-transplanted Human Ovarian Tissue Against Ischemia and Reperfusion Injury

Zhu

et al. 2021

Cell Transplant

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“…Adequately powered and better-designed RCTs are required, including the identification of more appropriate markers of liver function or dysfunction under treatment of UTI. Along with recent UTI related clinical studies also indicated the anti-inflammatory effect in the IR injury and hence plays a predominant role in organ protection (39)(40)(41). This may aid in the treatment of patients undergoing hepatectomy with vascular occlusion and improve outcome.…”

Section: Quality Of Evidence and Future Trialsmentioning

confidence: 90%

Perioperation ulinastatin intervention protects liver function in hepatectomy: a systematic review of randomized controlled trials and meta-analysis

Gao¹,

Lyu²,

Yang³

et al. 2020

Ann Palliat Med

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Background: Vascular occlusion during hepatectomy accompanies ischemia-reperfusion (IR) injury, which can cause liver dysfunction and affect patients' outcome. Ulinastatin or urinary trypsin inhibitor (UTI), a polyvalent inhibitor of various enzymes, has been confirmed of anti-IR injury effect in recent studies. Here we performed a systematic review and meta-analysis to assess the benefits of perioperation UTI using to protect liver function in hepatectomy.Methods: Randomized controlled trials (RCTs) evaluating UTI in hepatectomy were identified. Two independent reviewers extracted data on basic characteristics and risk of bias in the studies, and on outcomes such as alanine transaminase (ALT), aspartate transaminase (AST), and total bilirubin (TBIL) from 1 to 7 days after operation.Results: A total of 9 RCTs including 408 UTI and 372 control participants were identified. There was no significant difference in basic characteristics such as age or sex. The majority of the patients who underwent hepatectomy had primary liver carcinoma, liver metastases and benign liver lesions. A significant improvement in liver function was associated with UTI use not only at 1 and 3 days postoperatively, but also at 7 days (all P≤0.01). However, significant heterogeneity existed between the pooled studies (all P<0.01).Conclusions: UTI has positive protective effects against IR injury in hepatectomy. However, further highquality RCTs are needed to confirm this conclusion.

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“…in the present study, noB could relieve i/r injury in the kidney. The levels of Bun and serum cr were used as indicators of renal injury (31). compared with the sham group, serum cr and Bun levels were increased in the i/r group, indicating that renal function was critically impaired.…”

Section: Discussionmentioning

confidence: 99%

Nobiletin alleviates ischemia/reperfusion injury in the kidney by activating PI3K/AKT pathway

et al. 2020

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recent studies have demonstrated that nobiletin (NOB) displays anti-oxidative and anti-apoptotic efficacies against multiple pathological insults. However, the potential effects of noB on the injury caused by ischemia and reperfusion (i/r) in the kidney remain undetermined. in the present study, i/r injury was elicited by right kidney removal and left renal pedicel clamping for 45 min, followed by reperfusion for 24 h. noB was added at the start of reperfusion. Histological examination, detection of biomarkers in plasma, and measurement of apoptosis induced by endoplasmic reticulum stress (erS) were used to evaluate renal injury. additionally, the Pi3K/aKT inhibitor lY294002 was also used in mechanistic experiments. NOB pre-treatment significantly reduced renal damage caused by i/r injury, as indicated by decreased serum levels of creatine, blood urea nitrogen and tubular injury scores. Furthermore, noB inhibited elevated erS-associated apoptosis, as evidenced by reduced apoptotic rates and erS-related signaling molecules (such as, c/eBP homologous protein, caspase-12 and glucose-regulated protein of 78 kda). noB increased phosphorylation of proteins in the Pi3K/aKT pathway. The inhibition of Pi3K/aKT signaling with pharmacological inhibitors could reverse the beneficial effects of NOB during renal i/r insult. in conclusion, noB pre-treatment may alleviate i/r injury in the kidney by inhibiting reactive oxygen species production and erS-induced apoptosis, partly through the Pi3K/aKT signaling pathway.

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Intravenous infusion of ulinastatin attenuates acute kidney injury after cold ischemia/reperfusion

Cited by 16 publications

References 34 publications

Protective Effects of Reduced Glutathione and Ulinastatin on Xeno-transplanted Human Ovarian Tissue Against Ischemia and Reperfusion Injury

Protective Effects of Reduced Glutathione and Ulinastatin on Xeno-transplanted Human Ovarian Tissue Against Ischemia and Reperfusion Injury

Perioperation ulinastatin intervention protects liver function in hepatectomy: a systematic review of randomized controlled trials and meta-analysis

Nobiletin alleviates ischemia/reperfusion injury in the kidney by activating PI3K/AKT pathway

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