Intravenous iron sucrose in malnourished children with iron deficiency anemia.

Nazir, Fahad; Khurshid, Asim; Talib, Muhammad Abu

doi:10.29309/tpmj/2020.27.09.4107

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…documented. A rise in posttreatment hemoglobin levels implies that erythropoietic recovery is achieved with intravenous iron sucrose which also 16,18 strengthens the findings of our study. The most common side effect in our study is fever 10% whereas the study by Mantadakis et al reported the most common adverse effect of parental iron to be injection site extravasation followed by a 19 transient alteration in taste.…”

Section: Table II :Feeding History and Diagnosis At The Time Of Admis...supporting

confidence: 87%

Parental Iron Therapy to Treat Iron Deficiency Anemia in Malnourished Children

Khan¹,

Ma²,

Abbas³

et al. 2022

JIIMC

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Objective: To evaluate the safety and efficacy of parental iron therapy to treat iron deficiency anemia in malnourished children. Study Design: Quasi experimental design. Place and Duration of Study: Stabilization Centre, Children Hospital and the Institute of Child Health, Multan from 1 December 2014 to 31 December 2020. Materials and Methods: A total of 250 malnourished children with iron deficiency were included in the study. The laboratory parameters i.e., Hemoglobin, Hematocrit, Red Blood Cells Count, mean corpuscular hemoglobin, mean corpuscular volume, and Serum ferritin of all patients were done. Using the iron deficit formula, all participants were given the measured iron sucrose complex. The iron sucrose complex was diluted with 0.9% normal saline and administered steadily for 3-4 hours. After 6 weeks of therapy, hemoglobin, RBC count , ferritin was measured. Comparison of mean ±SD of baseline laboratory parameters and after 6 weeks of iron supplementation was analyzed by using t-test. Results: A total of 250 participants were registered, male patients (57.2%) were more than female patients (42.8 %). Most of the 92(36.8%) participants were 12-24 months old. The key cause of anemia among 102(40.8%) admitted patients was inadequate diet or excessive milk consumption. The mean ±SD value of the Hb level at admission was 7.5±1.9 and it increased to 11±1.15g/dL after 6 weeks of active supplementation which is statistically significant (P-value < 0.05). Six weeks after giving intravenous iron therapy mean serum Ferritin increased from 11.5ml to 21.61 ng/ml. Conclusion: Current study concluded that controlled administration of IV iron sucrose for treatment of iron deficiency anemia among inpatients is efficacious and safe. IV iron sucrose should be considered for patient with severe IDA, those who are not compliant with oral formulations, and patients with malabsorption.

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Section: Table II :Feeding History and Diagnosis At The Time Of Admis...supporting

confidence: 87%

Parental Iron Therapy to Treat Iron Deficiency Anemia in Malnourished Children

Khan¹,

Ma²,

Abbas³

et al. 2022

JIIMC

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show abstract

“…Similarly, our study outcomes find resonance with a study recently conducted in Multan, reporting a statistically significant increase in mean Hb levels after six weeks of active supplementation 11 . Another national study documented that parenteral iron sucrose therapy improved mean Hb levels in malnourished children with IDA 12 . Meanwhile, another Pakistani study reported Hb levels rising to 9.21±1.13 g/dL with IV iron sucrose therapy 14 .…”

Section: Discussionmentioning

confidence: 99%

“…Our study in Pakistan sets itself apart from most others. Instead of focusing solely on malnourished children, as many studies have done before 11,12 , we are taking a broader approach. We're including children with iron deficiency anemia, no matter their nutritional status.…”

Section: Introductionmentioning

confidence: 99%

Mean Rise in Hemoglobin After Intravenous Iron Therapy in Children with Iron Deficiency Anemia

Ammara Mushtaq Khan,

Zulfiqar,

Amna Saleem

et al. 2024

Proceedings S.Z.M.C

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Introduction: Iron deficiency anemia (IDA) is a significant public health issue in Pakistan, affecting up to 63% of children, as revealed by the Pakistan National Nutritional Survey 2018. While oral iron remains the primary choice, challenges in compliance have led to the consideration of intravenous (IV) iron therapy, particularly iron sucrose. The study discusses the safety and efficacy of IV iron therapy in Pakistani children and aims to broaden our understanding of treating IDA in resource-constrained regions. Aims & Objectives: To determine the average hemoglobin (Hb) increase in iron-deficient-anemic children aged 01 to 12 years after treatment with intravenous iron sucrose. Place and Duration of Study: A quasi-experimental study was undertaken at Fauji Foundation Hospital in Rawalpindi, spanning from September 2021 to September 2022. Material & Methods: The study focused on a cohort of pediatric patients aged between 1 and 12 years, all of whom were diagnosed with iron deficiency anemia and had previously encountered ineffective outcomes with oral iron therapy. In this investigation, the patients received treatment involving intravenous iron sucrose. Subsequently, their progress was diligently monitored after a period of 8 weeks. Improvement in hemoglobin level was assessed at the end of treatment to evaluate its efficacy.Data processing and statistical analysis were carried out using SPSS version 23,p-value of <0.05 indicated statistical significance. Results: Out of 150 study cases, 96 (64.0 %) were male, while 54 (36.0 %) were female. The mean age of our study cases was 05 ± 2.3 years of these 150 study cases, 74 (49.3 %) belonged to rural areas, and 76 (50.7 %) belonged to urban areas. Poor socioeconomic status was noted in 97 (64.7 %), and 53 (35.3%) were middle-income. A family history of iron deficiency anaemia was recorded in 16 (10.7%). Iron deficiency due to dietary iron insufficiency was reported in 67 (44.7%), Total Parentral Nutrition (TPN) dependencywas seen in 61 (40.7%) and 22 (14.7%) had chronic gastritis. The mean baseline (pretreatment) haemoglobin level was 7.71 ± 0.63 g/dl, while the mean post-treatment haemoglobin level was 10.68 ± 0.60 g / dl (p = 0.001). Conclusion: After intravenous iron sucrose, we noted a significant rise in paediatric patients' hemoglobin levels, emphasizing its effectiveness and safety. Statistically, we found correlations with age, family history, and causes. Healthcare practitioners should consider injectable iron treatments for better results and reduced health issues in this group.

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Intravenous iron sucrose in malnourished children with iron deficiency anemia.

Cited by 2 publications

References 7 publications

Parental Iron Therapy to Treat Iron Deficiency Anemia in Malnourished Children

Parental Iron Therapy to Treat Iron Deficiency Anemia in Malnourished Children

Mean Rise in Hemoglobin After Intravenous Iron Therapy in Children with Iron Deficiency Anemia

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