Intravenous levetiracetam in acute repetitive seizures and status epilepticus in children: Experience from a children's hospital

McTague, Amy; Kneen, Rachel; Kumar, Ram; Spinty, Stefan; Appleton, R

doi:10.1016/j.seizure.2012.05.010

Cited by 54 publications

(46 citation statements)

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“…The drug has since gained broader approvals for treatment of a variety of partial and generalized seizure conditions, including those in pediatric patients 13, 14. Levetiracetam has a therapeutic profile closer to ideal than most other anticonvulsants15 and the parenteral form is now used increasingly to manage cluster seizures and status epilepticus in the very young, elderly, and critically ill humans 16, 17, 18, 19, 20…”

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confidence: 99%

Levetiracetam Rectal Administration in Healthy Dogs

Peters

Schubert

Clemmons

et al. 2014

Veterinary Internal Medicne

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BackgroundLevetiracetam is used to manage status epilepticus (SE) and cluster seizures (CS) in humans. The drug might be absorbed after rectal administration and could offer a practical adjunct to rectal administration of diazepam in managing SE and CS.HypothesisLevetiracetam is rapidly absorbed after rectal administration in dogs and maintains target serum concentrations for at least 9 hours.AnimalsSix healthy privately owned dogs between 2 and 6 years of age and weighing 10–20 kg.MethodsLevetiracetam (40 mg/kg) was administered rectally and blood samples were obtained immediately before (time zero) and at 10, 20, 40, 60, 90, 180, 360, and 540 minutes after drug administration. Dogs were observed for signs of adverse effects over a 24‐hour period after drug administration.Results C LEV at 10 minutes was 15.3 ± 5.5 μg/mL (mean, SD) with concentrations in the target range (5–40 μg/mL) for all dogs throughout the sampling period. C max (36.0 ± 10.7 μg/mL) and T max (103 ± 31 minutes) values were calculated and 2 disparate groups were appreciated. Dogs with feces in the rectum at the time of drug administration had lower mean C max values (26.7 ± 3.4 μg/mL) compared with those without (45.2 ± 4.4 μg/mL). Mild sedation was observed between 60 and 90 minutes without other adverse effects noted.Conclusions and Clinical ImportanceThis study supports the use of rectally administered levetiracetam in future studies of clinical effectiveness in the management of epileptic dogs.

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confidence: 99%

Levetiracetam Rectal Administration in Healthy Dogs

Peters

Schubert

Clemmons

et al. 2014

Veterinary Internal Medicne

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“…Larger cohorts in adult patients basically confirmed an useful riskbenefit ratio of LEV-iv [6,7,19]. Data to support LEV-iv use in children with acute seizures or refractory SE are even more limited, but in case reports and in observational studies LEV-iv has also been reported to be an effective and safe adjuvant therapy in children with refractory SE [20,21]. The established status epilepticus trial (ESET) [22] was designed to compare the use of fos-phenytoin, valproate and levetiracetam regarding their efficacy in treating SE among patients older than 2 years after the use of benzodiazepines, and will possibly add further information to this important topic.…”

Section: Discussionmentioning

confidence: 89%

Intravenous levetiracetam in clinical practice – Results from an independent registry

Lang

Esser

Evers

et al. 2015

Seizure

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“…Intravenous preparation has recently shown efficacy in neonatal seizures and status epilepticus [15,16].…”

Section: Levetiracetammentioning

confidence: 99%

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2017

Cent Asian J Med Sci

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Objectives: Up to one third of epilepsy patients have an unsatisfactory treatment with antiepileptic drugs (AEDs), but advance in neuroimaging, neurophysiologic investigation and treatment modalities have substantially improved the approaches and understanding of intractable childhood epilepsy. Methods: Journal papers, reports, books and government publications on epilepsy treatment were collected and reviewed in chronological order. Results:There are approximately more than 15 newer AEDs developed since 1990, highlighted by the novel mechanism of action with minimal adverse effect, thus they have been frequently used for those who are unresponsive to conventional AEDs. Non-pharmacologic therapies including diet therapy, epilepsy surgery, and neuromodulatory treatment are also effective and should be considered early in the disease course. Diet therapy began to reemerge in mid 1990s, and studies with large data collection allowed to overcome major concerns; its side effects, difficult compliance and doubts on efficacy. And more liberal forms of the diet therapy were introduced to benefit adults and patients in developing counties, where strict supervision is unavailable. The surgical treatment has become increasingly more valuable and it is now accepted for the management of drug resistant focal epilepsy due to major advances in presurgical investigation methods, and surgical techniques. Conclusions: The timely assessment of children with drugresistant epilepsy and active application of advanced treatment modalities were necessary to prevent the effect of uncontrolled seizures on cognitive and behavioral development.

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Intravenous levetiracetam in acute repetitive seizures and status epilepticus in children: Experience from a children's hospital

Cited by 54 publications

References 29 publications

Levetiracetam Rectal Administration in Healthy Dogs

Levetiracetam Rectal Administration in Healthy Dogs

Intravenous levetiracetam in clinical practice – Results from an independent registry

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