Intravenous lipid emulsion in propanolol overdose

Dean, P.; Ruddy, James; Marshall, Stephen

doi:10.1111/j.1365-2044.2010.06526.x

Cited by 32 publications

(15 citation statements)

References 7 publications

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“…With regard to propranolol overdose, there are two published case reports that suggest a clinical response to ILE 11 12. In rabbits given an intravenous propranolol overdose, low blood pressure was corrected by 6 mL/kg infusion of 20% ILE 13.…”

Section: Discussionmentioning

confidence: 99%

Dramatic resuscitation with Intralipid in an epinephrine unresponsive cardiac arrest following overdose of amitriptyline and propranolol

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Dramatic resuscitation with Intralipid in an epinephrine unresponsive cardiac arrest following overdose of amitriptyline and propranolol

et al. 2017

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“…Another group of drugs that pose a risk of overdose, particularly in elderly populations, are cardiac medications, especially β‐blockers and calcium channel blockers. Overdoses with β‐blockers, propranalol 108 , 132 ‐ 134 and metoprolol 107 , 114 , 135 , 136 have been treated with LRT. However, animal studies have not demonstrated similarly promising results.…”

Section: Part Iii: Clinical Futurementioning

confidence: 99%

Past, Present, and Future of Lipid Resuscitation Therapy

Fettiplace

Weinberg

2015

J Parenter Enteral Nutr

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Lipid resuscitation therapy was identified in 1998 as an effective treatment for local anesthetic systemic toxicity in an animal model. Since the original observation, the field has progressed tremendously with successful clinical translation and expansion of use to treatment of other types of drug overdose. Recent work has expanded our understanding of the mechanism of this novel treatment, one that includes both a dynamic scavenging component and direct cardiotonic effect. In this review, we discuss the past, present, and future of lipid resuscitation therapy with a focus on our understanding of the mechanism and directions that the field is moving, both from a clinical and basic research side.

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“…After more than 20 min of asystole and no response to advanced cardiac life support the use of lipid emulsion reversed systemic toxicity, including seizures, electrocardiogram abnormalities, and cardiac arrest without neurological sequelae. Several reports on successful treatment of beta blockers toxicity have been published in recent years [38][39][40][41][42][43] . After 10 min of unsuccessful cardiopulmonary resuscitation, they administered a bolus of 100 mL of 20% lipid emulsion followed by continuous infusion of 10 mL per min.…”

Section: Antidote Use Of Ivfesmentioning

confidence: 99%