Intravenous lipid emulsion therapy in three cases of canine naproxen overdose

Abstract

Naproxen is a nonsteroidal anti-inflammatory drug with a long half-life and narrow margin of safety in dogs. Ingestion of > 5 mg/kg has been associated with adverse gastrointestinal effects, including ulceration. At doses > 10-25 mg/kg, acute kidney failure has been reported, and at doses > 50 mg/kg, neurologic abnormalities occur. This is the first reported use of IVLE for treatment of naproxen overdose with documented decrease in serum toxin concentrations shortly after administration. No long-standing gastrointestinal, renal, or neurologic effects occurred in these dogs.

Effect of Intravenous Lipid Emulsion on Clozapine Acute Toxicity in Rats

“…There are many reports on the efficacy of intravenous lipid emulsion (ILE) as an antidotal candidate in intoxication with medications [1–3]. Investigations and case reports about this novel benefit of ILE result in adding it into Guidelines for the Management of Severe Local Anesthetic Toxicity [4–6].…”

Nonsteroidal Anti-Inflammatory Drug Toxicity in Children

“…66 Intravenous lipid emulsion for management of NSAID toxicity has been reported in canine subjects, but its use in humans requires further investigation. 67,68 Given the questionable effectiveness of these elimination strategies, their use is not routinely recommended.…”

Nonsteroidal Anti-Inflammatory Drug Toxicity in Children

“…Due to its high protein-bound state, direct removal of NSAIDs through hemodialysis is ineffective. 67,68 Given the questionable effectiveness of these elimination strategies, their use is not routinely recommended. 52,59 In 1 case report, a patient underwent plasmapheresis for removal of phenylbutazone-a NSAID used in veterinary medicine-with good outcome.…”