Intravenous macrolide use: a reminder of the dangers of rapid infusion rates

Ratcliffe, Andrew; Ismail, Khaled M.

doi:10.1016/j.jclinane.2012.01.001

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Although AZM administered in the ICU can be affected by various other drugs, we think that there should be no objection to the necessity for caution. In the ICU, patients are often managed in a sedated state, which may cause delay in their complaints of vascular pain 19 . Therefore, we consider the results of this study to be reasonable.…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Study of Injection Site Pain from Azithromycin Injection in Japanese Patient

Tanaka

Hayashi

Awaya

et al. 2020

Showa Univ J Med Sci

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Azithromycin AZM injection tends to increase injection site pain when administered in excess of 2 mg / ml. As AZM is frequently used in combination therapies, it is expected to be administered at a high concentration in clinical use due to uid restrictions. Therefore, in this study, the relation between AZM concentration and injection site pain was examined. From January 2012 to July 2017, we retrospectively investigated the medical records of patients who were administered AZM by injection at Showa University Fujigaoka Hospital. Vascular pain was related to intensive care unit ICU administration P 0.003 compared with that in general wards and a long duration of administration P 0.002. The number of days of AZM injection should be kept as short as possible. Given that the risk of injection site pain is increased in the ICU, we recommend switching to oral administration. Further collection of safety data in patients on uid restriction is necessary, and high concentration AZM administration should be considered.

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Section: Discussionmentioning

confidence: 99%

A Retrospective Study of Injection Site Pain from Azithromycin Injection in Japanese Patient

Tanaka

Hayashi

Awaya

et al. 2020

Showa Univ J Med Sci

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Clarithromycin

2013

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Clarithromycin Thrombophlebitis in an elderly patient: case reportA 72-year-old man developed thrombophlebitis following treatment with clarithromycin [therapeutic indication not stated].The man was scheduled for corrective surgery for an umbilical hernia; anaesthesia was maintained with propofol and fentanyl, and morphine was administered during surgery. IV clarithromycin [dosage not stated] was administered intraoperatively due to a penicillin allergy. Left hand discolouration, venous engorgement, was noted after a short stay in recovery [duration of treatment to reaction onset not stated]. Rapid capillary refill was observed, and the IV cannula, located dorsally in the hand, was removed. Additional inflammation moving up the cephalic vein of the left forearm was observed on re-examination, and he was diagnosed with thrombophlebitis secondary to IV clarithromycin.Heparin was initiated, and the man's thrombophlebitis resolved the next day.Author comment: "Localized tenderness and phlebitis are both recognized in the British National Formulary as known side effects of IV clarithromycin administration."Ratcliffe AT, et al. Intravenous macrolide use: A reminder of the dangers of rapid infusion rates.

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Intravenous macrolide use: a reminder of the dangers of rapid infusion rates

Cited by 2 publications

References 8 publications

A Retrospective Study of Injection Site Pain from Azithromycin Injection in Japanese Patient

A Retrospective Study of Injection Site Pain from Azithromycin Injection in Japanese Patient

Clarithromycin

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