Intravenous Magnesium as an Adjuvant in Acute Bronchospasm: A Meta-Analysis

Alter, Harrison J.; Koepsell, Thomas D.; Hilty, William M.

doi:10.1067/mem.2000.109170

Cited by 83 publications

(34 citation statements)

References 39 publications

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“…Cuenta con una amplia franja de seguridad y disponibilidad para su uso, por lo que creemos que es factible difundir su empleo en la sala de emergencias o la UCIP de manera regular, en concordancia con lo expuesto en nuestro estudio y en la bibliografía internacional. 16 Nuestros hallazgos se encuentran en consonancia con lo evidenciado en las distintas revisiones sobre el tema, focalizadas en objetivos similares a los nuestros, acerca de la disminución en los días de internación y una menor cantidad de niños que necesitaron asistencia ventilatoria mecánica.…”

Section: Discussionunclassified

Eficacia del sulfato de magnesio como tratamiento inicial del asma aguda grave pediátrica. Estudio aleatorizado y controlado

et al. 2012

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Eficacia del sulfato de magnesio como tratamiento inicial del asma aguda grave pediátrica. Estudio aleatorizado y controladoEffectiveness of magnesium sulfate as initial treatment of acute severe asthma in children. A randomized, controlled trial RESUMEN Introducción. El sulfato de magnesio es un antagonista del calcio que inhibe la contracción del músculo liso bronquial y favorece la broncodilatación. Se utiliza en el manejo del asma aguda grave en pediatría no obstante haber sido la mayoría de los estudios desarrollados en adultos.

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Section: Discussionunclassified

Eficacia del sulfato de magnesio como tratamiento inicial del asma aguda grave pediátrica. Estudio aleatorizado y controlado

et al. 2012

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“…However, in a recently published series of cases, sugammadex did not modify the course of the reaction [61]. Magnesium sulphate may be useful in cases of bronchospasm that are refractory to other treatments [62].…”

Section: Vasoactive Drugsmentioning

confidence: 99%

Practical Guidelines for Perioperative Hypersensitivity Reactions

Laguna¹,

Archilla²,

Doña³

et al. 2018

J Investig Allergol Clin Immunol

105

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Perioperative hypersensitivity reactions constitute a first-line problem for anesthesiologists and allergists, so it is advisable that hospitals have a consensus protocol for the diagnosis and management of these reactions. However, this kind of protocols is not present in many hospitals, leading to problems in treatment, the communication of incidents and subsequent etiological diagnosis. In this document we present a systematic review of the available scientific evidence and provide general guidelines for the management of acute episodes and Resumen:Las reacciones de hipersensibilidad perioperatorias constituyen un problema de primera línea para los anestesiólogos y alergólogos, por lo que es recomendable que los hospitales tengan un protocolo de consenso para el diagnóstico y el tratamiento de estas reacciones. Sin embargo, este tipo de protocolos no está presente en muchos hospitales, lo que conlleva problemas en el tratamiento, la comunicación de incidentes y el posterior diagnóstico etiológico. Este documento ha sido creado por miembros del Comité de Alergia a Medicamentos de la Sociedad Española de Alergia e Inmunología Clínica (SEAIC) en colaboración con miembros de la Sociedad Española de Anestesia (SEDAR). Se ha realizado una revisión sistemática de la evidencia científica disponible y se proporcionan pautas generales para el manejo de episodios agudos y para la derivación de pacientes con reacciones de hipersensibilidad perioperatoria a los Servicios de Alergología. Se propone un algoritmo práctico para el diagnóstico etiológico y se brindan recomendaciones para el manejo de pacientes con reacciones alérgicas perioperatorias.

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“…The divergences were confirmed by three meta-analyses presenting the results discussed [2,24,20]. Cheuk et al [6] published a metaanalysis in 2005 on intravenous magnesium sulfate for treating acute asthma in children.…”

Section: The Use Of Magnesium In Treating Bronchial Asthma Exacerbationmentioning

confidence: 57%

The use of magnesium in bronchial asthma: a new approach to an old problem

Kowal

Panaszek

Barg

et al. 2007

Arch. Immunol. Ther. Exp.

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Magnesium deficiency is a common electrolyte disorder in patients with acute severe asthma, but intracellular magnesium content better reflects its homeostasis than does its serum concentration. Magnesium takes part in many metabolic processes in the organism, including energy metabolism, protein and nucleic acid synthesis, cell cycle, the binding of substances to the plasma membrane, and maintenance of cytoskeletal and mitochondrial integrity. It also modulates ion transport and influences intracellular calcium concentration. Maintenance of the cells' transmembrane gradient depends on the presence of magnesium, and hypomagnesemia may result in an increase in neuromuscular cell excitability. Magnesium is a cation modulating the smooth muscle contractility of different tissues: hypomagnesemia causes their contraction and hypermagnesemia their relaxation. Suggestions of a positive influence of magnesium in the treatment of asthma exacerbation have been known for a long time, but research results differ. A single dose of intravenous magnesium sulfate given to patients with acute asthma exacerbation has been shown to be safe, but its efficiency is still under discussion. According to the Global Initiative for Asthma GINA-2005, magnesium sulfate administration is not recommended for routine treatment, but it is permitted in patients with severe asthma exacerbation not responding to treatment (evidence category A). Recommendations of the British Thoracic Society allow one dose of magnesium sulfate to patients with acute severe asthma exacerbation and inadequate initial response to broncho-dilating inhalation treatment (evidence category A). Future investigations should help to establish the indications for magnesium use in the treatment of acute asthma exacerbations as well as the magnesium dose and the scheme of its administration.

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Intravenous Magnesium as an Adjuvant in Acute Bronchospasm: A Meta-Analysis

Cited by 83 publications

References 39 publications

Eficacia del sulfato de magnesio como tratamiento inicial del asma aguda grave pediátrica. Estudio aleatorizado y controlado

Eficacia del sulfato de magnesio como tratamiento inicial del asma aguda grave pediátrica. Estudio aleatorizado y controlado

Practical Guidelines for Perioperative Hypersensitivity Reactions

The use of magnesium in bronchial asthma: a new approach to an old problem

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