Intravenous magnesium sulfate for bronchial hyperreactivity: A randomized, controlled, double‐blind study

Schenk, Peter; Vonbank, Karin; Schnack, Beate; Haber, Paul; Lehr, Stephan; Smetana, Ronald

doi:10.1067/mcp.2001.114926

Cited by 17 publications

(9 citation statements)

References 30 publications

(43 reference statements)

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“…A randomized, controlled, and double-blind study demonstrated a significant improvement in methacholine-provoked bronchial hyperreactivity in 30 patients after intravenous MgSO 4 (0.3 mmol ⅐ kg Ϫ1 ⅐ h Ϫ1 ). 127 Several case reports support these findings, one of which describes continuous magnesium infusion to facilitate rapid extubation and recovery in a ventilated patient not responding to standard bronchodilating therapy. 128 Inhaled Magnesium.…”

Section: Mechanisms Of Actionmentioning

confidence: 94%

Magnesium—Essentials for Anesthesiologists

et al. 2011

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Magnesium plays a fundamental role in many cellular functions, and thus there is increasing interest in its role in clinical medicine. Although numerous experimental studies indicate positive effects of magnesium in a variety of disease states, large clinical trials often give conflicting results. However, there is clear evidence for magnesium to benefit patients with eclampsia or torsades de pointes arrhythmias. In addition, magnesium seems to have antinociceptive and anesthetic as well as neuroprotective effects, yet well-designed large clinical trials are required to determine its actual efficacy in pain management or in the state of stroke or subarachnoid hemorrhage. The current review aims to provide an overview of current knowledge and available evidence with respect to physiologic aspects of magnesium and proposed indications and recommendations for its use in the clinical setting.

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Section: Mechanisms Of Actionmentioning

confidence: 94%

Magnesium—Essentials for Anesthesiologists

et al. 2011

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“…Some studies have observed its impact on the management of neuritis, deltoid bursitis, and myalgias. 17 , 18 , 19 …”

Section: Introductionmentioning

confidence: 99%

Effect of magnesium sulfate iontophoresis on myofascial trigger points in the upper fibres of the trapezius

Ibrahim

Raoof

Mosaad

et al. 2021

Journal of Taibah University Medical Sciences

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Objective To investigate the immediate and post-treatment effect of magnesium sulfate (MgSO4) iontophoresis on myofascial trigger points (MTrPs) in the upper fibres of the trapezius muscle. Method Sixty participants (41 women and 19 men, aged 19–24 years) with active MTrPs on the dominant upper fibres of trapezius were enrolled in this study. They were randomly divided into 2 equivalent groups: the intervention and the control group. The intervention group (iontophoresis group; n = 30) was treated with MgSO4 iontophoresis on the upper fibres of the trapezius twice a week for four weeks, and the control group (direct current group; n = 30) received direct current (without medication) in the upper fibres of the trapezius twice a week for four weeks. The outcome measures were: pain intensity, pain threshold, neck range of motion, and neck function The participants were assessed before treatment, immediately after the first session, and finally after treatment. Results The differences within and between groups were measured using a mixed design, multivariate analysis of variance (MANOVA). The within- and between-group analysis of all outcome measures in both groups revealed significant differences in favour of the intervention group ( p < 0.05). Conclusion MgSO4 iontophoresis is effective in improving pain level, neck ROM, and neck function immediately after the first session and causes more significant improvement after treatment in subjects with active MTrPs on the dominant upper fiber of trapezius.

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“…These studies have proved that hypomagnesaemia in asthma is associated with increased incidence of wheeze, impairment of lung function, and increased bronchial hyper-reactivity (BHR). As mentioned before, low magnesium level may enhance calcium movement inside the smooth muscle cell and making the cell more contractile and thus increasing BHR [6,7]. Mg deficiency may also increase production of acetylcholine in cholinergic nerve endings, increase histamine release from mast cell, increase production of interlukin-1 and 6, and enhance production of IgE [20,21].…”

Section: Discussionmentioning

confidence: 99%

“…Mg has several actions on bronchial airways including bronchodilation, anticholinergic effects, and stabilization of mast cells [4,5]. Hence, Mg deficiency leads to increased contractility of bronchial smooth muscle and increased airways hyperreactivity [6,7].…”

Section: Introductionmentioning

confidence: 99%

Estimation of Serum Magnesium level among Patients with Bronchial Asthma in Erbil -Iraq

Saidoka¹,

Zangana²,

Lak³

2019

DJM

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Background:Bronchial asthma is a common chronic respiratory disease worldwide. Although magnesium (Mg) deficiency has been shown to play a role in exacerbation of asthma, the exact prevalence of hypomagnesaemia in asthma is not clear. Objective: To estimate the serum Mg levels in bronchial asthma patients and compare them with healthy population and to evaluate the prevalence of hypomagnesaemia among them. Patients and Methods: A cross-sectional study was carried out in the respiratory unit of Rizgary Teaching Hospital involving 80 adult patients with chronic asthma (group I) and 80 healthy adult controls (group II). Serum magnesium level was measured in all the participants. Results: Hypomagnesaemia was detected in 20% of the asthmatic patients when compared to controls (0%) (p=0.001). No significant association was detected between magnesium status and type of asthma (p= 0.59). There was a statistically significant stage-wise decline in serum levels of Mg with increase in severity of asthma (p=0.02). Patients with severe asthma had the highest prevalence of hypomagnesaemia (45.5%) in comparison to mild and moderate cases (p=0.001). No significant associations were detected between the level of magnesium and the number of medications that the patients used, corticosteroids use, and theophylline therapy (p=0.06, 0.17, and 0.08, respectively). Hypomagnesaemia was significantly correlated with the duration of asthma (p=0.04). Conclusion: Hypomagnesaemia is more prevalent in chronic asthmatics than non-asthmatics. Hypomagnesaemia was significantly correlated with severity and duration of asthma.

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Intravenous magnesium sulfate for bronchial hyperreactivity: A randomized, controlled, double‐blind study

Abstract: In the magnesium group, 30% of the subjects reached a normal PC(20) compared with 10% in the placebo group. We conclude that intravenous magnesium sulfate significantly improved bronchial hyperreactivity and may serve as an adjunct to standard treatment.

Cited by 17 publications

References 30 publications

Magnesium—Essentials for Anesthesiologists

Magnesium—Essentials for Anesthesiologists

Effect of magnesium sulfate iontophoresis on myofascial trigger points in the upper fibres of the trapezius

Estimation of Serum Magnesium level among Patients with Bronchial Asthma in Erbil -Iraq

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