Intravenous Magnesium Sulfate Inhibits Catecholamine Release Associated with Tracheal Intubation

James, Michael F.; Beer, Raphael; Eßer, J

doi:10.1213/00000539-198906000-00015

Cited by 148 publications

(105 citation statements)

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“…22,23 Puri et al also reported similar observation with the changes in mean arterial pressure (MAP). 24 They reported that MAP decreased significantly (p<0.001) from after administering the study drug in the magnesium Group as compared to control group though MAP increased after intubation in both the Groups, it was significantly (p<0.001) higher than the base line in control Group as compared to magnesium group where the levels were just near baseline after intubation.…”

Section: Blood Pressurementioning

confidence: 66%

“…22,23 They assessed the effects of pre-treatment with intravenous magnesium sulphate 60 mg/kg on cardiovascular responses and the release of catecholamines associated with tracheal intubation in otherwise normal subjects compared to normal saline pretreated controls. They found that induction of anesthesia produced no changes in HR in either Group, but magnesium pre-treatment produced initial increase in HR by 13±3.9 beats/minute.…”

Section: Heart Ratementioning

confidence: 99%

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A prospective randomised study comparing intravenous magnesium sulphate and sublingual nitroglycerine spray in attenuating haemodynamic responses to laryngoscopy and intubation

Kotwani

Hiwarkar³

2018

Int J Clin Trials

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Background: Laryngoscopy and tracheal Intubation are invariably associated with certain stress responses due to the sympatho-adrenal stimulation. These cardiovascular and neurohumoral alterations may directly affect the physiology and increase the risk. So far, various drugs have been tried but none has been considered ideal for blunting this presser response. We therefore, planned this comparative study to evaluate and compare the efficacy of intravenous magnesium sulphate (30 mg/kg) versus sublingual nitroglycerine spray (0.4 mg/spray) in attenuating the presser response to Laryngoscopy and Tracheal Intubation.Methods: Fifty patients, aged 15–50 years, scheduled for elective surgery under general anaesthesia, were randomly assigned to one of the two groups of 25 each, Group A (magnesium group) and Group B (nitroglycerine group). Study drug was given 90-120 seconds before tracheal intubation. Heart rate, Systolic blood pressure and Rate pressure product were recorded at different intervals after administering the study drug till 3 minutes after intubation.Results: Mean heart rate was significantly higher from the baseline at all times after administering the study drug in both the groups. Increase in systolic blood pressure as a presser response was limited to 7.25% in Group A and 5.83% in Group B from the baseline after tracheal intubation. There was relative hypotension after administration of the study drug in both the groups.Conclusions: Intravenous magnesium or sublingual nitroglycerine pre-treatment is found to be effective in attenuating the presser response to laryngoscopy and intubation. These drugs may lead to rise in HR but it is transient and dose dependent. However, both the drugs can significantly control the hypertensive response after laryngoscopy and intubation.

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Section: Blood Pressurementioning

confidence: 66%

Section: Heart Ratementioning

confidence: 99%

A prospective randomised study comparing intravenous magnesium sulphate and sublingual nitroglycerine spray in attenuating haemodynamic responses to laryngoscopy and intubation

Kotwani

Hiwarkar³

2018

Int J Clin Trials

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“…James ve ark. (6) tiyopental ile anestezi indüksiyo-nunda 60 mg kg -1 magnezyum sülfat uyguladıklarında, trakeal entübasyona bağ-lı katekolamin salınımı ve kardiyovasküler yanıtı baskıladığını ve entübasyon sonrasında ölçülen epinefrin ve norepinefrin düzeylerinin düşük olduğunu göstermiş-tir. Bu çalışmaya benzer şekilde yapılan birçok çalışmada da entübasyon öncesi magnezyum sülfat kullanımının stres yanıtı ciddi ölçüde azalttığına yönelik veriler bulunmaktadır.…”

Section: Discussionunclassified

“…Bu çalışmaya benzer şekilde yapılan birçok çalışmada da entübasyon öncesi magnezyum sülfat kullanımının stres yanıtı ciddi ölçüde azalttığına yönelik veriler bulunmaktadır. (6)(7)(8)(9) Puri ve ark. (10) elektif koroner arter bypas greft operasyonu uygulanacak ve entü-basyona stres yanıtın tehlikeli olabileceği öngörülen koroner arter hastaları ile yaptıkları çalışmada, laringoskopiye stres yanıtı azaltmak için sıklıkla kullanılan lidokain ile magnezyum sülfatı karşılaştır-mıştır.…”

Section: Discussionunclassified

The Usage of Magnesium Sulphate During Induction and Maintenance of General Anesthesia

Canturk¹,

Turgut²,

Altan³

et al. 2011

J Turk Anaesth Int Care

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ÖZETAmaç: Çalışmamızda; tiroid cerrahisi planlanan hastalarda anestezi indüksiyonu ve devamında MgSO 4 kullanılması-nın anestezik ajan gereksinimi, kas gevşetici tüketimi, peroperatif hemodinami, postoperatif derlenme ve postoperatif analjezi üzerine etkilerini araştırmayı amaçladık. Bulgular: Entübasyon sonrası ve intraoperatif 15. dk. ortalama arter basınçları, kalp atım hızı Grup K'da daha yüksek saptandı. İndüksiyonda gereken propofol miktarı ve idamedeki % Fi sevofluran, rokuronyum tüketimi Grup M'de daha azdı. T1 % 10 yanıtı ve T1 % 25 yanıt süreleri Grup M'de daha geç gerçekleşti. Ekstübasyon, verbal uyarılara yanıt, sözel yanıt, Aldrete Skoru 10 olma zamanı Grup M'de daha uzun bulundu. Grup M'de VAS değerleri 10. dk., 20. dk. ve 30. dk.'larda daha düşük bulundu ve ilk analjezik gereksinim zamanı daha uzun sürede gerçekleşti.Sonuç: Perioperatif MgSO 4 kullanılması; entübasyona hemodinamik yanıtı, anestezi indüksiyonu ve anestezi uygulamasının sürdürülmesinde anestezik madde gereksinimini azaltmakta, rokuronyumun etkisini potansiyalize etmekte ve postoperative ağrı kontrolüne olumlu etki göstermektedir.Anahtar kelimeler: Magnezyum sülfat, tiroid, rokuronyum SUMMARY The Usage of Magnesium Sulphate During Induction and Maintenance of General AnesthesiaAim: We aimed to investigate the effects of MgSO 4 used during induction and maintenance of general anesthesia on anesthetic drug requirement, consumption of muscle relaxants, preoperative hemodynamics, postoperative recovery, and postoperative analgesia in patients scheduled for thyroid surgery.Material and Methods: Fifty patients (ASA I-II) were randomly allocated into two groups; Group M received 30 mg kg -1 MgSO 4 15 minutes before induction followed by 15 mg kg -1 h -1 MgSO 4 infusion, and Group K 0.9 % NaCI. Anesthesia was induced with intravenous administration of 20 mg propofol, 1 µg fentanyl and 0.6 mg kg -1 rocuronium every 5 seconds keeping BIS at 60. 1 mg kg -1 i.v. for the maintenance of anesthesia sevoflurane was used so as to keep BIS between 50, and 60. Tramadol (1 mg kg -1 iv) was used for postoperative analgesia. Postoperative analgesia level was recorded at 10., 20., 30. min and 1., 2., 3., 6. h using Visual Analogue Scale (VAS), and 75 mg diclofenac sodium iv. was administered to patients with a score of 5 or higher. Kolmogorov-Smirnov, Student's t, Man-Whitney U and Chi-square test were used for statistical analysis.Results: Postintubation and intraoperative 15. minute MAP and HR values were significantly higher in Group K patients. Propofol requirement at induction, and FI % for sevoflurane, at maintenance and total rocuronium consumption were significantly lower in Group M. T1 10 % and T1 25 % response times were delayed in Group M. Extubation time, response to verbal stimuli, verbal response time, and time to reach a score of 10 modified Aldrete score of 10 were found to be prolonged in Group M. In Group M, 10., 20., 30. min VAS scores were lower, and time to the first requirement for an analgesic was also delayed.Conclusion: Peroperativ...

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“…Methods employed to attenuate the response include deepening the plane of anesthesia, treatment with vasodilators 10,11 adrenergic receptor blockers 9 , calcium channel blockers 10 and opioids. 12,13 Conventionally, IV lignocaine 1.5mg/ kg administered 90 sec before intubation is employed.…”

Section: Introductionmentioning

confidence: 99%

Effect of Oral Pregabalin on Hemodynamic Stress Response to Laryngoscopy and Endotracheal intubation

P.R¹

2017

jmscr

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Intravenous Magnesium Sulfate Inhibits Catecholamine Release Associated with Tracheal Intubation

Cited by 148 publications

References 0 publications

A prospective randomised study comparing intravenous magnesium sulphate and sublingual nitroglycerine spray in attenuating haemodynamic responses to laryngoscopy and intubation

A prospective randomised study comparing intravenous magnesium sulphate and sublingual nitroglycerine spray in attenuating haemodynamic responses to laryngoscopy and intubation

The Usage of Magnesium Sulphate During Induction and Maintenance of General Anesthesia

Effect of Oral Pregabalin on Hemodynamic Stress Response to Laryngoscopy and Endotracheal intubation

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