Intravenous methyl prednisolone in patients with solitary cysticercus granuloma: A random evaluation

Abstract

Intravenous methyl prednisolone therapy helps in early resolution of solitary cysticercus granuloma.

Natural history of solitary cerebral cysticercosis on serial magnetic resonance imaging and the effect of albendazole therapy on its evolution

“…Unlike patients from Latin America and Africa, Indian patients with NCC commonly have single or a few intraparenchymal cysts with minimal recurrence of seizures [24]. Around 60-70.8% of NCC in India is in the form of solitary cerebral cysticercal lesion (SCCL) [25,26].…”

Corticosteroid use in neurocysticercosis

“…Two studies by Mall et al [45] and Garg et al [46] compared 1 mg/kg prednisolone for 10 days per os and a 4-day taper plus antiepileptic drugs (AED) to AED alone, while a third study by Kishore et al compared the same drug regimen without a taper to AED alone [47]. The fourth study compared 1 g/1.72 m 2 intravenous methyl prednisolone for 5 days with AED to AED alone [48]. All four studies found a decrease in seizures (statistically significant in three out of four), mostly at 6–9 months, but three also found an accompanying significant disappearance of cysts on CT scan [45,47,48].…”

“…The fourth study compared 1 g/1.72 m 2 intravenous methyl prednisolone for 5 days with AED to AED alone [48]. All four studies found a decrease in seizures (statistically significant in three out of four), mostly at 6–9 months, but three also found an accompanying significant disappearance of cysts on CT scan [45,47,48]. By contrast, the only blinded randomized trial found no difference in disappearance at 6 months [46].…”

Randomized controlled trial of albendazole in new onset epilepsy and MRI confirmed solitary cerebral cysticercal lesion: Effect on long-term seizure outcome

“…Solitary cerebral cysticercal lesions (SCCL) are a common manifestation of NCC in India and account for 60-71% of all cases of NCC and 50% of all patients with new-onset focal and generalised seizures [11,12]. SCCL are known to resolve or calcify within 6 months in 70-85% of all patients [13].…”